Enhancing vaginal drug delivery: the nanoemulsion gel strategy DOI
Biswajit Basu, Dipanjana Ash, Ayon Dutta

et al.

Zeitschrift für Naturforschung C, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

Abstract In the 21st century, 75 % of women encounter vaginal malfunctions (cervicitis, mucoid ectopy, aerobic vaginitis, candidiasis, bacterial vaginosis, degenerated desquamative chronic and sexually transmitted infections) that clinically manifest as irritation, awkwardness, irregular bleeding, or evacuation. Vaginal drug delivery, an approach to treat aforementioned diseases, primarily focuses on epithelium thickness, cyclic changes, secretions, mucus enzymatic activity, pH, local microflora, presence efflux transporters for their fabrication. There has been a growing interest in nanoemulsion gel delivery vagina comparison conventional systems (rings gels). This review provides in-depth examination formulation, highlighting key considerations such choice vehicles, gel-forming agents, permeation enhancers. It further explores formulation techniques, stability issues, novel approaches like mucoadhesive controlled-release systems. The biocompatibility safety gels are also critically assessed, along with regulatory aspects. paper underscores significance these formulations management various conditions, including infections, hormonal therapies, contraceptive applications. As continue evolve, role optimizing offers considerable potential improving therapeutic outcomes patient compliance.

Language: Английский

Harnessing Oregano Nanoemulsion: A Novel Solution to Combat Curvalaria-Induced Fruit Rot and Preserve Mango Quality DOI

M. J. Gidado,

Ahmad Anas Nagoor Gunny,

Nor Amirah Azwa Norizal

et al.

Journal of Cluster Science, Journal Year: 2025, Volume and Issue: 36(2)

Published: Feb. 2, 2025

Language: Английский

Citations

0
Enhancing vaginal drug delivery: the nanoemulsion gel strategy DOI
Biswajit Basu, Dipanjana Ash, Ayon Dutta

et al.

Zeitschrift für Naturforschung C, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

Abstract In the 21st century, 75 % of women encounter vaginal malfunctions (cervicitis, mucoid ectopy, aerobic vaginitis, candidiasis, bacterial vaginosis, degenerated desquamative chronic and sexually transmitted infections) that clinically manifest as irritation, awkwardness, irregular bleeding, or evacuation. Vaginal drug delivery, an approach to treat aforementioned diseases, primarily focuses on epithelium thickness, cyclic changes, secretions, mucus enzymatic activity, pH, local microflora, presence efflux transporters for their fabrication. There has been a growing interest in nanoemulsion gel delivery vagina comparison conventional systems (rings gels). This review provides in-depth examination formulation, highlighting key considerations such choice vehicles, gel-forming agents, permeation enhancers. It further explores formulation techniques, stability issues, novel approaches like mucoadhesive controlled-release systems. The biocompatibility safety gels are also critically assessed, along with regulatory aspects. paper underscores significance these formulations management various conditions, including infections, hormonal therapies, contraceptive applications. As continue evolve, role optimizing offers considerable potential improving therapeutic outcomes patient compliance.

Language: Английский

Citations

0