Hydrogel-forming microarray patches combined with powder-based reservoir for labetalol hydrochloride transdermal delivery DOI Creative Commons
Qonita Kurnia Anjani, Usanee Detamornrat, Eneko Larrañeta

et al.

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown, P. 125061 - 125061

Published: Dec. 1, 2024

Hypertension is the most common pregnancy disorder and can lead to life-threatening conditions for both mother fetus. However, managing this condition with oral intravenous labetalol be challenging, highlighting need alternative delivery methods. This study presents, first time, development of novel powder-based reservoirs incorporated hydrogel-forming microarray patches (MAPs) facilitate transdermal hydrochloride (HCl). A holder, created from poly(propylene) using a 3D printer, was designed house HCl powder, which then combined MAPs. system improved insertion profile MAPs into Parafilm® layers excised full-thickness neonatal porcine skin, achieving up 85 % needle height penetration without compromising integrity (only 8 reduction after applying 32 N force). The current holder design able load 50 mg allowed single or multiple injections deionised water dissolve powder permeation through dermatomed skin in vitro studies Franz cell setup. results showed that reservoir delivered more effectively over 24 h compared directly compressed tablets. Additionally, poly(vinyl alcohol)/poly(vinyl pyrrolidone)/citric acid-based than Gantrez® S-97/poly(ethylene glycol)-based (9 vs. 5 mg) h. holds promise improving compounds simple manner, though further modifications one-step application are needed.

Language: Английский

Research progress on quercetin in improving the survival rate of random skin flap DOI

Siping Xu,

Wenhua Zhang, Xuanfen Zhang

et al.

Archives of Dermatological Research, Journal Year: 2025, Volume and Issue: 317(1)

Published: Jan. 16, 2025

Language: Английский

Citations

0
Dual ROS/Glucose-Responsive Quercetin-Loaded Supramolecular Hydrogel for Diabetic Wound Healing DOI
Chenguang Liu,

Ronger Ai,

Bizhi Liu

et al.

Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Diabetic wound healing remains a significant challenge due to complex pathological mechanisms, including prolonged inflammation, excessive reactive oxygen species (ROS) accumulation, angiogenesis dysfunction, and increased susceptibility bacterial infection. In this study, we developed dual ROS/glucose-responsive quercetin-loaded supramolecular hydrogel (GPQ hydrogel) for treating diabetic wounds. The was fabricated by incorporating quercetin (QUE) into guanosine–phenylboronic acid (GP) network through dynamic borate ester bonds. Structural characterization revealed the formation of typical G-quadruplex structure in GPQ hydrogel. responsiveness ROS glucose enabled controlled release QUE, effectively addressing abnormal microenvironment diabetes. vitro studies demonstrated excellent antibacterial, antioxidant, anti-inflammatory, pro-angiogenic properties Furthermore, vivo study using full-thickness model streptozotocin-induced rats showed that significantly accelerated closure, enhanced re-epithelialization collagen deposition, promoted compared control GP groups. Immunofluorescence analysis confirmed superior antioxidant effects microenvironment. This presents promising multifunctional biomaterial managing

Language: Английский

Citations

0
Soluplus®-Based Pharmaceutical Formulations: Recent Advances in Drug Delivery and Biomedical Applications DOI Open Access
Nerea Guembe-Michel, Paul Nguewa, Gustavo González‐Gaitano

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1499 - 1499

Published: Feb. 11, 2025

Poor water solubility remains a significant challenge in the pharmaceutical industry that limits therapeutic efficacy and bioavailability of many active pharmaceuticals. Soluplus® (SLP), an amphiphilic graft copolymer made polyethylene glycol, polyvinyl caprolactam, acetate, has been gaining interest recent years as it addresses these limitations by acting versatile carrier. Its ability to form stable amorphous dispersions enhance drug solubility, well its physicochemical properties, support role key excipient advanced delivery systems. Recent investigations have demonstrated adaptability SLP addressing requirements, offering controlled release, improved targeting, superior outcomes. This review examines some formulation methods make use SLP, including hot-melt extrusion, spray drying, electrospinning, drug–polymer layering, capsule tablet formulations, highlighting capacity overcome challenges. Biomedical applications also explored, with focus on improving antitumoral, anti-inflammatory, antimicrobial, antiparasitic drugs.

Language: Английский

Citations

0
Hydrogel-forming microarray patches combined with powder-based reservoir for labetalol hydrochloride transdermal delivery DOI Creative Commons
Qonita Kurnia Anjani, Usanee Detamornrat, Eneko Larrañeta

et al.

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown, P. 125061 - 125061

Published: Dec. 1, 2024

Hypertension is the most common pregnancy disorder and can lead to life-threatening conditions for both mother fetus. However, managing this condition with oral intravenous labetalol be challenging, highlighting need alternative delivery methods. This study presents, first time, development of novel powder-based reservoirs incorporated hydrogel-forming microarray patches (MAPs) facilitate transdermal hydrochloride (HCl). A holder, created from poly(propylene) using a 3D printer, was designed house HCl powder, which then combined MAPs. system improved insertion profile MAPs into Parafilm® layers excised full-thickness neonatal porcine skin, achieving up 85 % needle height penetration without compromising integrity (only 8 reduction after applying 32 N force). The current holder design able load 50 mg allowed single or multiple injections deionised water dissolve powder permeation through dermatomed skin in vitro studies Franz cell setup. results showed that reservoir delivered more effectively over 24 h compared directly compressed tablets. Additionally, poly(vinyl alcohol)/poly(vinyl pyrrolidone)/citric acid-based than Gantrez® S-97/poly(ethylene glycol)-based (9 vs. 5 mg) h. holds promise improving compounds simple manner, though further modifications one-step application are needed.

Language: Английский

Citations

0