Advancing neurological disorders therapies: Organic nanoparticles as a key to blood-brain barrier penetration

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: 670, P. 125186 - 125186

Published: Jan. 8, 2025

The blood-brain barrier (BBB) plays a vital role in protecting the central nervous system (CNS) by preventing entry of harmful pathogens from bloodstream. However, this also presents significant obstacle when it comes to delivering drugs for treatment neurodegenerative diseases and brain cancer. Recent breakthroughs nanotechnology have paved way creation wide range nanoparticles (NPs) that can serve as carriers diagnosis therapy. Regarding their promising properties, organic NPs potential be used effective drug delivery across BBB based on recent advancements. These remarkable ability penetrate using various mechanisms. This review offers comprehensive examination intricate structure distinct properties BBB, emphasizing its crucial function preserving balance regulating transport ions molecules. disruption conditions such stroke, Alzheimer's disease, Parkinson's disease highlights importance developing creative approaches drugs. Through encapsulation therapeutic molecules precise targeting processes vasculature, NP formulations present hopeful strategy improve BBB. We explore changes pathological investigate factors affect successful into brain. In addition, we most systems associated with shown positive results treating ischemic disorders. opens up new possibilities nanotechnology-based therapies cerebral diseases.

Language: Английский

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Inorganic Nanoparticles and Blood-Brain Barrier Modulation: Advancing Targeted Neurological Therapies

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 287, P. 117357 - 117357

Published: Feb. 5, 2025

Language: Английский

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Dissolving microneedles for brain delivery: Recent advances and challenges

Drug Discovery Today, Journal Year: 2025, Volume and Issue: unknown, P. 104330 - 104330

Published: March 1, 2025

Language: Английский

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Enhancing localized chemotherapy with anti-angiogenesis and nanomedicine synergy for improved tumor penetration in well-vascularized tumors

npj Systems Biology and Applications, Journal Year: 2024, Volume and Issue: 10(1)

Published: Nov. 20, 2024

Intratumoral delivery and localized chemotherapy have demonstrated promise in tumor treatment; however, the rapid drainage of therapeutic agents from well-vascularized tumors limits their ability to achieve maximum efficacy. Therefore, innovative approaches are needed enhance treatment efficacy such tumors. This study utilizes a mathematical modeling platform assess combination therapy using anti-angiogenic drugs drug-loaded nanoparticles. Anti-angiogenic included reduce blood microvascular density facilitate drug retention extracellular space. In addition, incorporating negatively charged nanoparticles aims diffusion distribution within The findings indicate that, case direct injection free drugs, compounds with lower rates higher coefficients is beneficial for achieving broader diffusion. Otherwise, tend accumulate primarily around site. For instance, doxorubicin, known its drainage, requires prior an high rate distribution, enhancing penetration depth by 200%. Moreover, results demonstrate that effectively disperse throughout tissue due coefficient. faster release further efficacy, necessary concentration complete eradication compared slower rates. demonstrates potential utilizing loaded exhibiting through intratumoral

Language: Английский

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Nanosystems at Nexus: Navigating Nose-to-Brain Delivery for Glioblastoma Treatment

Molecular Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Glioblastoma multiforme (GBM) is considered to be one of the most devastating brain tumors with a shorter life expectancy. Several factors contribute dismal prognosis GBM patients including complicated nature GBM, ability tumor cells resist treatment, and difficulty delivering drugs because barriers like blood-brain barrier (BBB) blood-tumor (BTB). The unique challenges posed by BBB in therapeutic agents have led development innovative nanotechnology-based approaches. By exploiting olfactory/trigeminal pathway, nanosystems offer promising strategy for targeted drug delivery brain, glioblastoma particular. This review contemplates varied nanocarriers, polymeric nanoparticles, lipid-based nanosystems, situ gel formulations, peptide, stem cell-based nanoformulations, signifying their utility targeting minimal systemic side effects. Emerging trends gene therapy immunotherapy context treatment also been discussed. Since safety paramount aspect any product get approved, this delves into toxicological considerations associated intranasal nanosystems. Regulatory aspects critical successful products are explored review. Overall, underscores significant advancements nanotechnology nose-to-brain its potential impact on management.

Language: Английский

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Modelling receptor-mediated endocytosis in hollow microneedle-based verapamil delivery through viscoelastic skin

Computer Methods in Biomechanics & Biomedical Engineering, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 19

Published: March 20, 2025

Drug delivered from the microneedle (MN) tip diffuses across viscoelastic skin before entering blood compartment and being absorbed. Reversible uptake kinetics between tissue compartments, reversible specific saturable binding with its receptors, endocytosis are given due attention. Simulations predict that, unlike thinning, viscoelasticity a higher Young's modulus value, as in an older person, inhibit verapamil diffusion within skin, metabolism stabilises concentrations compartments. Simultaneously, irreversible improve drug compartment, facilitating receptor-mediated endocytosis. The results also that internalised increases time at slower internalisation rates; however, rates, it attains peak value gradually diminishing. Furthermore, rate of lysosomal degradation escalates, concentration diminishes shifts upward. A comprehensive sensitivity analysis has been performed because uncertainty about several crucial parameters. Our findings align well existing literature.

Language: Английский

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Mesenchymal stromal cells in bone marrow niche of patients with multiple myeloma: a double-edged sword

Cancer Cell International, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 26, 2025

Abstract Multiple myeloma (MM) is a hematological malignancy defined by the abnormal proliferation and accumulation of plasma cells (PC) within bone marrow (BM). While multiple impacts bone, it not classified as primary cancer. The microenvironment significantly influences progression its treatment response. Mesenchymal stromal (MSCs) in this environment engage with other components via direct contact secretion soluble factors. This review examines established roles MSCs facets MM pathology, encompassing their pro-inflammatory functions, contributions to tumor epigenetics, effects on immune checkpoint inhibitors (ICIs), influence reprogramming, chemotherapy resistance, senescence. investigates role development MM.

Language: Английский

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Current Research in Drug-Free Cancer Therapies

Bioengineering, Journal Year: 2025, Volume and Issue: 12(4), P. 341 - 341

Published: March 26, 2025

Cancer treatment has historically depended on conventional methods like chemotherapy, radiation, and surgery; however, these strategies frequently present considerable limitations, including toxicity, resistance, negative impacts healthy tissues. In addressing challenges, drug-free cancer therapies have developed as viable alternatives, utilizing advanced physical biological to specifically target tumor cells while reducing damage normal This review examines several strategies, such high-intensity focused energy beams, nanosecond pulsed electric fields, photothermal therapy well the use of inorganic nanoparticles promote selective apoptosis. We also investigate significance targeting microenvironment, precision medicine, immunotherapy in progression personalized therapies. Although approaches demonstrate significant promise, challenges scalability, safety, regulatory obstacles must be resolved for clinical application. paper presents an overview current research therapies, emphasizing recent advancements, underlying scientific principles, steps required implementation.

Language: Английский

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Advancements in photoacoustic imaging for cancer diagnosis and treatment

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown, P. 124736 - 124736

Published: Sept. 1, 2024

Language: Английский

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Genetic-bioengineering of nanotechnology in cell-specific pharmaceutical targeting: Biological, pharmacological, and biochemical impact of nanomaterials-based breast cancer therapies

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: unknown, P. 106249 - 106249

Published: Oct. 1, 2024

Language: Английский

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