Optimized Hesperidin-Loaded Lipid Nanoparticles with Tea Tree Oil for Enhanced Wound Healing: Formulation, Characterization, and Evaluation
Pharmaceuticals,
Journal Year:
2025,
Volume and Issue:
18(3), P. 290 - 290
Published: Feb. 20, 2025
Objectives:
This
study
aimed
to
develop
hesperidin
solid
lipid
nanoparticles
(HESP-SLNs)
enhance
their
stability,
solubility,
and
sustained
release
for
wound
healing;
further
enhancement
was
achieved
through
prepared
nanostructured
carriers
(HESP-NLCs)
using
Tea
Tree
Oil
(TTO)
explore
synergistic
efficacy.
Methods:
A
factorial
design
of
24
trials
established
evaluate
the
influence
type
(X1),
conc
(%)
(X2),
surfactant
(X3),
sonication
amplitude
(X4)
HESP-SLNs
on
particle
size
(nm)
(Y1),
polydispersibility
index
(Y2),
zeta
potential
(Y3),
encapsulation
efficiency
(Y4).
The
optimized
formula
selected
utilizing
Design
Expert®
software
version
13,
which
additionally
enhanced
by
preparing
TTO-loaded
HESP-NLCs.
In
vitro
release,
Raman
spectroscopy,
transmission
electron
microscopy
were
carried
out
both
nanoparticles.
Cytotoxicity,
in
vivo
wound-healing
assessments,
skin
irritancy
tests
performed
performance
TTO-incorporated
HESP-NLCs
compared
HESP-SLNs.
Results:
demonstrated
PS
(280
±
1.35
nm),
ZP
(−39.4
0.92
mV),
PDI
(0.239
0.012),
EE%
(88.2
2.09%).
NLCs
Q6%
(95.14%)
vs.
(79.69%),
SLNs
showed
superior
antimicrobial
Both
exhibited
spherical
morphology
compatibility
between
HESP
excipients.
highest
closure
percentage,
supported
histological
analysis
inflammatory
biomarker
outcomes.
Cytotoxicity
evaluation
87%
cell
viability
untreated
HSF
cells,
test
confirmed
safety
NLCs.
Conclusions:
are
promising
candidates
exhibiting
capabilities,
making
them
a
therapeutic
option
cutaneous
management.
Language: Английский
The Incorporation of CBD into Biodegradable DL-Lactide/Glycolide Copolymers Creates a Persistent Antibacterial Environment: An In Vitro Study on Streptococcus mutans and Staphylococcus aureus
Ronit Vogt Sionov,
No information about this author
Ahmad Siag,
No information about this author
Emma Theresa Mersini
No information about this author
et al.
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(4), P. 463 - 463
Published: April 2, 2025
Background:
Cannabidiol
(CBD)
is
a
natural
compound
from
the
Cannabis
sativa
L.
plant,
which
has
anti-inflammatory,
anti-nociceptive,
neuroprotective,
and
antibacterial
activities.
Objective:
The
aim
of
this
study
was
to
develop
sustained-release
device
CBD
that
can
provide
an
effect
against
Gram-positive
bacteria
Streptococcus
mutans
Staphylococcus
aureus
for
extended
periods
time.
Methods:
incorporated
into
biodegradable
PURASORB
5010
or
7510
DL-lactide/glycolide
polymers
using
either
dimethylsulfoxide
(DMSO)
acetone
as
solvent,
dried
polymer
scaffolds
were
exposed
daily
fresh
culture
bacteria.
bacterial
growth
determined
by
optical
density,
metabolic
activity
biofilms
MTT
assay.
Biofilm
formation
on
visualized
HR-SEM.
Its
anti-inflammatory
measuring
IL-6
release
LPS-stimulated
RAW
264.7
macrophages
ELISA.
Cell
cytotoxicity
normal
Vero
epithelial
cells
gas
chromatography–mass
spectrometry
(GC-MS).
Results:
5010/CBD
had
S.
UA159,
ATCC25923,
clinical
isolate
multidrug-resistant
(MDRSA
CI-M)
strain
tested
period
up
17
days.
7510/CBD
also
activity,
but
overall,
it
less
effective
than
over
addition
PEG400
copolymers
significantly
increased
not
5010/CBD.
sufficient
reduce
LPS-induced
secretion
macrophages,
importantly,
cytotoxic
cells.
found
be
between
1.12
9.43
µg/mL,
far
below
dose
25
µg/mL.
Conclusions:
incorporation
used
prepare
devices
medical
purposes
where
combined
activities
are
desirable.
Language: Английский
Sorghum Grain-Derived Kafirin Nanoparticles For Effective Delivery of Corosolic Acid into Breast Cancer Cells for Potential Treatment of Breast Cancer
Journal of Cluster Science,
Journal Year:
2025,
Volume and Issue:
36(3)
Published: April 4, 2025
Language: Английский
Codelivery of Paclitaxel and Cannabidiol in Lipid Nanoparticles Enhances Cytotoxicity against Melanoma Cells
ACS Omega,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 22, 2025
Language: Английский
Unravelling a potential therapeutic effect of polymeric lipid-core nanoencapsulated cannabidiol on anxiety- and panic-like behaviours elicited by Bothrops jararaca lancehead pit vipers
Bruno Mangili de Paula Rodrigues,
No information about this author
Paloma Molina Hernandes,
No information about this author
Rafael Canalle Balvedi
No information about this author
et al.
International Journal of Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
unknown, P. 125747 - 125747
Published: May 1, 2025
Language: Английский