Association of the ADRB2 rs1042714 variant with retinopathy of prematurity highlights the importance of the renin-angiotensin-aldosterone system DOI Creative Commons
Anna Chmielarz-Czarnocińska, Anna Durska,

Bartosz Skulimowski

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 2, 2025

Retinopathy of prematurity (ROP) remains a leading cause childhood blindness globally. The clinical progression ROP exhibits notable similarities to infantile hemangioma (IH), suggesting shared risk factors and underlying mechanisms. This study aimed investigate the influence variants in genes postulated for IH-specifically, anthrax toxin receptor 1 (ANTXR1), beta-2-adrenergic (ADRB2), Fms-related tyrosine kinase 4 (FLT4), insert domain (KDR), insulin-like growth factor (IGF1R)-on development severity ROP. In our analysis 210 infants born at gestational age less than 33 weeks, we identified ADRB2 rs1042714G variant allele as significant ROP, particularly its proliferative form. was exacerbated by interactions with associated neonatal respiratory failure, such surfactant therapy, postnatal resuscitation, mechanical ventilation, well angiotensin II type (AGTR1 rs5186A > C), previously linked meta-analyses. Moreover, STRING protein-protein interaction revealed that protein interacts directly component vascular endothelial signaling pathway. These findings highlight potential pharmacological targets interventions, emphasizing importance understanding genetic contributions this complex condition.

Language: Английский

Association of the ADRB2 rs1042714 variant with retinopathy of prematurity highlights the importance of the renin-angiotensin-aldosterone system DOI Creative Commons
Anna Chmielarz-Czarnocińska, Anna Durska,

Bartosz Skulimowski

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 2, 2025

Retinopathy of prematurity (ROP) remains a leading cause childhood blindness globally. The clinical progression ROP exhibits notable similarities to infantile hemangioma (IH), suggesting shared risk factors and underlying mechanisms. This study aimed investigate the influence variants in genes postulated for IH-specifically, anthrax toxin receptor 1 (ANTXR1), beta-2-adrenergic (ADRB2), Fms-related tyrosine kinase 4 (FLT4), insert domain (KDR), insulin-like growth factor (IGF1R)-on development severity ROP. In our analysis 210 infants born at gestational age less than 33 weeks, we identified ADRB2 rs1042714G variant allele as significant ROP, particularly its proliferative form. was exacerbated by interactions with associated neonatal respiratory failure, such surfactant therapy, postnatal resuscitation, mechanical ventilation, well angiotensin II type (AGTR1 rs5186A > C), previously linked meta-analyses. Moreover, STRING protein-protein interaction revealed that protein interacts directly component vascular endothelial signaling pathway. These findings highlight potential pharmacological targets interventions, emphasizing importance understanding genetic contributions this complex condition.

Language: Английский

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