Unveiling biological activities of biosynthesized starch/silver-selenium nanocomposite using Cladosporium cladosporioides CBS 174.62

BMC Microbiology, Journal Year: 2024, Volume and Issue: 24(1)

Published: March 8, 2024

Abstract Background and objectives Microbial cells capability to tolerate the effect of various antimicrobial classes represent a major worldwide health concern. The flexible multi-components nanocomposites have enhanced physicochemical characters with several improved properties. Thus, different biological activities biosynthesized starch/silver-selenium nanocomposite (St/Ag-Se NC) were assessed. Methodology St/Ag-Se NC was using Cladosporium cladosporioides CBS 174.62 ( C. ) strain. shape average particle size investigated scanning electron microscope (SEM) high-resolution transmission (HR-TEM), respectively. On other hand, on two cancer cell lines red blood (RBCs) evaluated its hydrogen peroxide (H 2 O scavenging Moreover, effects microbial species in both planktonic biofilm growth forms examined. Results successfully oval spherical mean diameter 67.87 nm as confirmed by HR-TEM analysis. showed promising anticancer activity toward human colorectal carcinoma (HCT-116) breast (MCF-7) where IC 50 21.37 19.98 µg/ml, Similarly, little RBCs observed low concentration. As well, highest H (42.84%) recorded at concentration mg/ml. Additionally, Staphylococcus epidermidis S. ATCC 12,228 Candida albicans 10,231 highly affected bacterial fungal strains minimum inhibitory concentrations (MICs) 18.75 noticeable dependent. A high suppression percentage, 87.5% 68.05%, aureus when exposed 1 mg/ml 0.5 mg/ml, Conclusion excellent antioxidant activity, haemocompatibility, anti-proliferative concentrations. Also, it exhibited antibiofilm activities.

Language: Английский

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Breaking Barriers in Eco-Friendly Synthesis of Plant-Mediated Metal/Metal Oxide/Bimetallic Nanoparticles: Antibacterial, Anticancer, Mechanism Elucidation, and Versatile Utilizations

Journal of Nanomaterials, Journal Year: 2024, Volume and Issue: 2024, P. 1 - 48

Published: April 12, 2024

Nanotechnology has emerged as a promising field in pharmaceutical research, involving producing unique nanoscale materials with sizes up to 100 nm via physiochemical and biological approaches. Nowadays more emphasis been given eco-friendly techniques for developing nanomaterials enhance their applications minimize health environmental risks. With the help of green nanotechnology, wide range metal, metal oxide, bimetallic nanoparticles distinct chemical compositions, sizes, morphologies have manufactured which are safe, economical, environment friendly. Due biocompatibility vast potential biomedical (antibacterial, anticancer, antiviral, analgesic, anticoagulant, biofilm inhibitory activity) other fields such (nanofertilizers, fermentative, food, bioethanol production, construction field), garnered significant interest worldwide. The precursors combined natural extracts plants, algae, fungi, bacteria get potent novel Ag, Au, Co, Cu, Fe, Zr, Zn, Ni, Pt, Mg, Ti, Pd, Cd, Bi2O3, CeO2, Co3O4, CoFe2O4, CuO, Fe2O3, MgO, NiO, TiO2, ZnO, ZrO2, Ag-Au, Ag-Cr, Ag-Cu, Ag-Zn, Ag-CeO2, Ag-CuO, Ag-SeO2, Ag-TiO2, Ag-ZnO, Cu-Ag, Cu-Mg, Cu-Ni, Pd-Pt, Pt-Ag, ZnO-CuO, ZnO-SeO, ZnO-Se, Se-Zr, Co-Bi2O3. These plant-mediated possess excellent antibacterial anticancer activity when tested against several microorganisms cancer cell lines. Plants contain essential phytoconstituents (polyphenols, flavonoids, terpenoids, glycosides, alkaloids, etc.) compared sources (bacteria, algae) higher concentration that play vital role development because these plant-phytoconstituents act reducing, stabilizing, capping agent helps nanoparticles. After concluding all findings, this review designed first time way it imparts satisfactory knowledge about together, along mechanisms. Additionally, provides information characterization (UV–vis, FT-IR, DLS, XRD, SEM, TEM, BET, AFM) employed nanoparticles, applications, industries. Hence, various types versatile application diverse is not covered pieces literature.

Language: Английский

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Dual extracellular mycofabrication of cobalt and zinc nano metal oxides mediated by mycelial-cell free filtrate of Aspergillus sojae: Characterization and assessment of antibacterial activity

Journal of Molecular Structure, Journal Year: 2023, Volume and Issue: 1300, P. 137190 - 137190

Published: Nov. 27, 2023

Language: Английский

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Metallic nanoparticles: a promising novel therapeutic tool against antimicrobial resistance and spread of superbugs

BioMetals, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 24, 2024

Language: Английский

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Green synthesis and characterization of silver-doped ZnO nanoparticles using tobacco leaf extract: A novel hydrothermal approach for antibacterial and antifungal applications

AIP Advances, Journal Year: 2025, Volume and Issue: 15(4)

Published: April 1, 2025

A green synthesis of pure zinc oxide and silver-doped nanoparticles (ZnO Ag–ZnO NPs) is reported. This eco-friendly method utilizes tobacco leaf aqueous extract as a reducing stabilizing agent, combined with hydrothermal process at 120 °C for 6 h to control nanoparticle formation. study aimed synthesize, characterize, evaluate the antimicrobial activity NPs. Characterization techniques included FTIR, XRD, SEM, UV‒Vis, PL spectroscopy, along BET surface area analysis. FTIR confirmed functional groups, while x-ray diffraction (XRD) validated hexagonal wurtzite ZnO structure. SEM imaging revealed nanosheet morphology. UV‒Vis analysis showed bandgap energy shifting Ag doping: 2.02 eV (pristine ZnO) 2.29 (3% Ag), 2.53 (5% 3.53 (1% Ag). indicated decrease in (132.251 m2/g pristine 85.005 1% 65.318 5% Ag) pore volume higher content. spectroscopy examined electron‒hole recombination. Antimicrobial against Staphylococcus aureus, Escherichia coli, Candida albicans was evaluated via disk diffusion assay, using ciprofloxacin fluconazole controls. Two-way ANOVA significant differences zone inhibition across varying concentrations doping levels (p < 0.005). Enhanced antibacterial S. aureus observed increasing doping, E. coli limited susceptibility. The NPs exhibited antifungal C. albicans. Bandgap, area, are controllable characteristics suggesting applications biomedicine, photovoltaics, photocatalysis.

Language: Английский

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Green ZnO nanoparticle synthesis using Tamarindus indica and application as a potent antibacterial and anticancer agent

Sustainable Chemistry for Climate Action, Journal Year: 2025, Volume and Issue: unknown, P. 100083 - 100083

Published: May 1, 2025

Language: Английский

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Green Synthesis, Characterization, and Potential Antibacterial and Anticancer Applications of Gold Nanoparticles: Current Status and Future Prospects

Biomedicines, Journal Year: 2025, Volume and Issue: 13(5), P. 1184 - 1184

Published: May 13, 2025

Drug resistance is a serious problem for human health worldwide. Day by day this drug increasing and creating an anxious situation the treatment of both cancer infectious diseases caused pathogenic microorganisms. Researchers are trying to solve terrible overcome resistance. Biosynthesized gold nanoparticles (AuNPs) could be promising agent controlling drug-resistant microorganisms cells. AuNPs can synthesized via chemical physical approaches, carrying many threats ecosystem. Green synthesis using biological agents such as plants microbes most fascinating attractive alternative physicochemical it offers advantages, simplicity, non-toxicity, cost-effectiveness, eco-friendliness. Plant extracts contain numerous biomolecules, produce various metabolites that act reducing, capping, stabilizing during AuNPs. The characterization green-synthesized has been conducted multiple instruments including UV–Vis spectrophotometry (UV–Vis), transmission electron microscopy (TEM), scanning (SEM), atomic force (AFM), X-ray diffraction (XRD), DLS, Fourier transform infrared spectroscopy (FT-IR). have detrimental effects on bacterial cells disruption cell membranes, fragmentation DNA, production reactive oxygen species, impairment metabolism. biocompatibility biosafety must investigated proper in vitro vivo screening model system. In review, we emphasized green, facile, eco-friendly their potential antimicrobial anticancer applications highlighted antibacterial mechanisms. This study demonstrates may potentially used control bacteria well

Language: Английский

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Comparative Analysis of Morphological and Structural Properties of Zinc Oxide Nanoparticles Synthesized by Sonochemical Method and Microbial Method

Plasmonics, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 7, 2024

Language: Английский

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Preliminary screening of endophytic fungi hosted some wild plants in North Sinai for biogenic production of silver nanoparticles

Microbial Biosystems, Journal Year: 2024, Volume and Issue: 8(2), P. 57 - 73

Published: Feb. 14, 2024

The biological synthesis of silver nanoparticles offers a promising alternative to traditional physical and chemical methods due its inherent simplicity, non-toxic nature, environmental friendliness. Within this study, endophytic fungi hosted six wild plants in Arish City, North Sinai, Egypt have been isolated by surface sterilization technique on different isolation media. Twelve species, based their frequency occurrence, out thirty recovered taxa were tested for capability synthesize extracellular AgNPs. Aspergillus terreus (OQ119631) flavus (OQ119633) from Hyoscyamus muticus Zygophyllum album respectively found be the best candidate production mycogenic AgNPs among all examined species. Mycogenic characterized UV-visible spectroscopy Transmission Electron Microscopy both taxa. synthesized demonstrated antimicrobial efficacy against various pathogenic bacteria fungi. Additionally, cytotoxicity was assessed human normal fibroblast cell line (BJ) using viability assay. results revealed substantial growth inhibition with IC50 concentration 100 µg/mL, indicating effectiveness diseased cells while maintaining relative safety towards healthy cells. This underscores potential eco-friendly produced native targeted cytotoxicity.

Language: Английский

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Zinc oxide nanoparticles derived from Penicillium griseofulvum mitigate DMBA/TPA-promoted mice skin carcinogenesis by modulating NF-ĸB associated signalling

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: July 30, 2024

Language: Английский

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