Evaluation of Antibacterial, Antioxidant, and Anticataleptic Activity on Methanol Seed Extract of <i>Cannabis sativa</i>: An <i>In Vitro</i> and <i>In Vivo</i> Study DOI Open Access

Dasaprakash Annadurai,

Kavita Raj,

M. Francis

et al.

Journal of Natural Remedies, Journal Year: 2024, Volume and Issue: unknown, P. 2713 - 2725

Published: Dec. 31, 2024

Background: Cannabis sativa (CS) has been traditionally used for its medicinal properties, including antioxidant, antibacterial, and neuroprotective effects. However, potential anticataleptic activity remains unexplored. Aim: This study aimed to investigate the qualitative phytochemical analysis, of methanolic seed extract (CSCME). Methods: The antioxidant CSCME was evaluated using DPPH radical scavenging assay. Antibacterial properties were assessed agar well diffusion method. For study, Wistar albino rats (n=30) divided into five groups: control, disease control (haloperidol 1mg/kg), standard treatment 1mg/kg + trihexyphenidyl two groups receiving haloperidol with (10mg/kg 20mg/kg). Treatments administered daily 15 days, catalepsy severity block metal bar methods. Results: exhibited significant antibacterial comparable commercial drugs. In vivo, results showed a reduction in cataleptic scores (P<0.05) compared control. Notably, 20mg/kg group demonstrated similar reductions as (P>0.05). Conclusion: demonstrates that possesses activities, suggesting therapeutic agent managing other neurological disorders. findings warrant further investigation clinical applications CSCME.

Language: Английский

Evaluation of Antibacterial, Antioxidant, and Anticataleptic Activity on Methanol Seed Extract of <i>Cannabis sativa</i>: An <i>In Vitro</i> and <i>In Vivo</i> Study DOI Open Access

Dasaprakash Annadurai,

Kavita Raj,

M. Francis

et al.

Journal of Natural Remedies, Journal Year: 2024, Volume and Issue: unknown, P. 2713 - 2725

Published: Dec. 31, 2024

Background: Cannabis sativa (CS) has been traditionally used for its medicinal properties, including antioxidant, antibacterial, and neuroprotective effects. However, potential anticataleptic activity remains unexplored. Aim: This study aimed to investigate the qualitative phytochemical analysis, of methanolic seed extract (CSCME). Methods: The antioxidant CSCME was evaluated using DPPH radical scavenging assay. Antibacterial properties were assessed agar well diffusion method. For study, Wistar albino rats (n=30) divided into five groups: control, disease control (haloperidol 1mg/kg), standard treatment 1mg/kg + trihexyphenidyl two groups receiving haloperidol with (10mg/kg 20mg/kg). Treatments administered daily 15 days, catalepsy severity block metal bar methods. Results: exhibited significant antibacterial comparable commercial drugs. In vivo, results showed a reduction in cataleptic scores (P<0.05) compared control. Notably, 20mg/kg group demonstrated similar reductions as (P>0.05). Conclusion: demonstrates that possesses activities, suggesting therapeutic agent managing other neurological disorders. findings warrant further investigation clinical applications CSCME.

Language: Английский

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