Journal of Investigative Surgery, Journal Year: 2024, Volume and Issue: 37(1)
Published: Oct. 28, 2024
Fracture healing can be impeded or even compromised by various factors, resulting in a growing number of patients suffering. The lncRNA LINC-PINT has garnered attention for its latent role enhancing fracture healing, but specific functions this process remain unclear.
Language: Английский
iScience, Journal Year: 2024, Volume and Issue: 27(6), P. 109979 - 109979
Published: May 15, 2024
This review explores the hallmarks of cancer resistance, including drug efflux mediated by ATP-binding cassette (ABC) transporters, metabolic reprogramming characterized Warburg effect, and dynamic interplay between cells mitochondria. The role stem (CSCs) in treatment resistance regulatory influence non-coding RNAs, such as long RNAs (lncRNAs), microRNAs (miRNAs), circular (circRNAs), are studied. chapter emphasizes future directions, encompassing advancements immunotherapy, strategies to counter adaptive integration artificial intelligence for predictive modeling, identification biomarkers personalized treatment. comprehensive exploration these provides a foundation innovative therapeutic approaches, aiming navigate complex landscape enhance patient outcomes.
Language: Английский
Citations
19
Molecular Therapy — Nucleic Acids, Journal Year: 2024, Volume and Issue: 35(2), P. 102184 - 102184
Published: March 30, 2024
Nonalcoholic steatohepatitis (NASH) represents a severe disease subtype of nonalcoholic fatty liver (NAFLD) that is thought to be highly associated with systemic metabolic abnormalities. It characterized by series substantial damage, including hepatocellular steatosis, inflammation, and fibrosis. The end stage NASH, in some cases, may result cirrhosis carcinoma (HCC). Nowadays large number investigations are actively under way test various therapeutic strategies, emerging oligonucleotide drugs (e.g., antisense oligonucleotide, small interfering RNA, microRNA, mimic/inhibitor activating RNA) have shown high potential treating this fatal disease. This article systematically reviews the pathogenesis NASH/NAFLD, promising druggable targets proven current studies chemical compounds or biological drug development, feasibility limitations oligonucleotide-based approaches clinical pre-clinical studies.
Language: Английский
Citations
9
Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14
Published: June 17, 2024
The substantial heterogeneity exhibited by head and neck cancer (HNC), encompassing diverse cellular origins, anatomical locations, etiological contributors, combined with the prevalent late-stage diagnosis, poses significant challenges for clinical management. Genomic sequencing endeavors have revealed extensive alterations in key signaling pathways that regulate proliferation survival. Initiatives to engineer therapies targeting these dysregulated are underway, several candidate molecules progressing evaluation phases, including FDA approval agents like EGFR-targeting monoclonal antibody cetuximab K-RAS wild-type, EGFR-mutant HNSCC treatment. Non-coding RNAs (ncRNAs), owing their enhanced stability biological fluids important roles intracellular intercellular within HNC contexts, now recognized as potent biomarkers disease management, catalyzing further refined diagnostic therapeutic strategies, edging closer personalized medicine desideratum. Enhanced comprehension of genomic immunological landscapes characteristic is anticipated facilitate a more rigorous assessment targeted benefits limitations, optimize deployment, foster innovative advancements treatment approaches. This review presents an update on molecular mechanisms mutational spectrum driving oncogenesis malignancies explores implications advancing methodologies precision therapeutics.
Language: Английский
Citations
5
The Journal of Gene Medicine, Journal Year: 2023, Volume and Issue: 26(1)
Published: Oct. 28, 2023
Abstract Introduction Renal cell carcinoma (RCC) is a grave malignancy that poses significant global health burden with over 400,000 new cases annually. Disulfidptosis, newly discovered programmed death process, linked to the actin cytoskeleton, which plays vital role in maintaining shape and survival. The of disulfidptosis poorly depicted clear histologic variant RCC (ccRCC). Methods Three sets ccRCC cohorts, ICGC_RECA‐EU ( n = 91), GSE76207 32) TCGA‐KIRC 607), were included our study, batch effect was removed using “combat” function. Correlation calculated “rcorr” function “Hmisc” package for Pearson analysis, visualized “pheatmap” package. Principal component analysis performed by “vegan” package, “scatterplot3d” Long non‐coding RNAs (lncRNAs) associated screened out least absolute shrinkage selection operator (LASSO) COX analysis. Tumor mutation, immune landscaping immunotherapy prediction further characterization two risk groups. Results A total 1822 disulfidptosis‐related lncRNAs selected, among 308 found be significantly clinical outcome patients. We retained 11 lncRNAs, namely, AP000439.3, RP11‐417E7.1, RP11‐119D9.1, LINC01510, SNHG3, AC156455.1, RP11‐291B21.2, EMX2OS, AC093850.2, HAGLR RP11‐389C8.2, through LASSO prognosis model construction, displayed satisfactory accuracy (area under curve, AUC, values all above 0.6 multiple cohorts) stratification prognosis. nomogram constructed integrating factors score, enhanced efficacy (AUC 0.7 cohorts). patients male gender, higher stages advanced pathological T stage inclined have score values. Dactinomycin_1911, Vinblastine_1004, Daporinad_1248 Vinorelbine_2048 identified as promising candidate drugs treating value. Moreover, value prone resistant immunotherapy. Conclusion developed predicting based on selected verified different cohorts. Furthermore, we delineated an intricate portrait tumor topography pharmacosensitivity evaluations within disparate stratifications.
Language: Английский
Citations
12
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: July 12, 2024
Objective Ferroptosis and necroptosis are two recently identified forms of non-apoptotic cell death. Their dysregulation plays a critical role in the development progression Psoriasis (PsD) Atherosclerosis (AS). This study explores shared necroptosis-related genes elucidates their molecular mechanisms PsD AS through analysis public databases. Methods Data sets for (GSE30999) (GSE28829) were retrieved from GEO database. Differential gene expression (DEG) weighted co-expression network (WGCNA) performed. Machine learning algorithms candidate biomarkers, whose diagnostic values assessed using Receiver Operating Characteristic (ROC) curve analysis. Additionally, levels these biomarkers models quantitatively measured Western Blot (WB) real-time quantitative PCR (RT-qPCR). Furthermore, CIBERSORT evaluated immune infiltration tissues, highlighting correlation between characteristic cells. Predictive drugs targeting was conducted DGIdb database, an lncRNA-miRNA-mRNA related to constructed. Results We 44 differentially expressed ferroptosis-related (DE-FRGs) 30 (DE-NRGs). GO KEGG enrichment analyses revealed significant immune-related inflammatory pathways, especially NOD-like receptor TNF signaling pathways. Two (NAMPT, ZFP36) eight (C7, CARD6, CASP1, CTSD, HMOX1, NOD2, PYCARD, TNFRSF21) showed high sensitivity specificity ROC These findings corroborated external validation datasets models. Immune increased T cells gamma delta, Macrophages M0, M2 samples. we 43 5 genes. Notably, XIST-miR-93–5p-ZFP36/HMOX1 NEAT1-miR-93–5p-ZFP36/HMOX1 pathways have been as promising RNA regulatory PsD. Conclusion The potential key AS. significantly influence pathogenesis by modulating macrophage activity, participating regulation, mediating responses.
Language: Английский
Citations
4
Archives of Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: unknown, P. 110324 - 110324
Published: Feb. 1, 2025
Language: Английский
Citations
0
Animal Cells and Systems, Journal Year: 2025, Volume and Issue: 29(1), P. 135 - 148
Published: Feb. 11, 2025
Circadian rhythms are 24-hour cycles in various biological processes, such as sleep, wake, and hormone secretion, controlled by an internal clock. Disruption of circadian has been related to human diseases. Abnormal expression rhythm-related genes, CLOCK, BMAL1, PER1, PER2, CRY1, CRY2, RORα, NPAS2, REV-ERBα TIMELESS also reported be associated with cancer. NPAS2 cancer development. In contrast, RORα inhibit development progression. Furthermore, studies suggest that genes can regulated ncRNAs miRNAs, lncRNAs circRNAs dysregulation these contributes Here, we summarize the mechanisms whereby ncRNA leads abnormal several cancers gene-associated regulatory contribute resistance chemo – radiotherapy. This review provides insights into mechanistic involvements network
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2126 - 2126
Published: Feb. 27, 2025
Melanoma is the deadliest form of skin cancer, and its treatment poses significant challenges due to aggressive nature resistance conventional therapies. Long non-coding RNAs (lncRNAs) represent a new frontier in search for suitable targets control melanoma progression invasiveness. Indeed, lncRNAs exploit wide range regulatory functions along chromatin remodeling, gene transcription, post-transcription, transduction, post-transduction ultimately tune multiple cellular processes. The understanding this intricate flexible network orchestrated by pathological conditions can strategically support rational identification promising targets, speeding up setup therapeutics integrate currently available approaches. Here, most recent findings on involved will be analyzed. In particular, functional links between their mechanisms action some frequently underestimated features, like different subcellular localizations, highlighted.
Language: Английский
Citations
0
Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)
Published: March 6, 2025
lncRNAs are key regulators in thyroid cancer (TC). While lncRNA ACVR2B-AS1 has been proposed as a potential TC biomarker, its role remains underexplored. This study aims to clarify clinical significance and investigate molecular mechanism. qRT-PCR was used assess the expression of tissues cell lines. Kaplan-Meier survival curves Cox regression were utilized prognostic value expression. The interaction between miR-195-5p, well their effects on viability, migration, invasion, evaluated using dual-luciferase reporter assays, CCK-8 Transwell assays. significantly upregulated lines, correlated with TNM stage lymph node metastasis. Elevated levels associated poor outcomes, it identified an independent risk factor for progression. A direct regulatory relationship established negatively regulating thereby promoting proliferation, invasion. FGF2 predicted validated target gene miR-195-5p. shows marker may regulate tumor progression through miR-195-5p/FGF2 axis, offering new insights diagnosis treatment.
Language: Английский
Citations
0
Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)
Published: March 8, 2025
Colorectal cancer (CRC) is the second leading cause of cancer-related mortality. Using Galaxy platform, present study aimed to assess differentially expressed genes (DEGs) in CRC patients. The expression data was obtained from Gene Expression Omnibus database (GSE137327). DEGs were analyzed using Ontology (GO) and GeneMANIA databases detect most critical biological pathways processes. Protein–Protein Interaction Studies (PPIS) identified four hub (CCN1, CCL2, FLNC, MYH11). This article presents findings on three mRNAs (CEMIP, MMP7, DPEP1) also two notable lncRNAs, EVADR DLX6-AS1, that have an impact pathogenesis play a role epithelial-mesenchymal transition tumor cells. lncRNAs are putative therapeutic targets diagnostic markers. For instance, CRISPR/Cas9 editing systems can be designed order modulate these genes, or edit them for purpose inducing sensitivity conventional therapies. Besides, incorporated into clinical prognostic models, offering panels choose appropriate personalized methods treatment. Together, represent novel markers possible CRC.
Language: Английский
Citations
0