Cancer Letters,
Journal Year:
2024,
Volume and Issue:
611, P. 217433 - 217433
Published: Dec. 28, 2024
The
nervous
system
governs
both
ontogeny
and
oncology.
Foundational
discoveries
have
clarified
the
direct
communication
of
neurotransmitters
with
tumors
indirect
interactions
through
neural
effects
on
immune
tumor
microenvironment.
Meantime,
is
susceptible
to
cancer
its
treatment.
Chemotherapy-induced
peripheral
neuropathy
(CIPN)
most
common
side
that
significantly
reduce
efficacy
anti-cancer
treatment
patients'
quality
life
by
leading
dose
reduction
or
early
cessation
chemotherapy.
However,
there
are
no
effective
strategies
reverse
treat
CIPN.
A
better
understanding
mechanisms
expected
enable
development
next
generation
therapies.
Here,
we
summarize
recent
important
studies
clinical
manifestations,
risk
factors,
prediction,
pathogenesis,
prevention,
We
also
provide
perspectives
insights
regarding
rationales
bidirectional
between
system.
Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
16
Published: Feb. 28, 2025
Cancer
remains
a
leading
cause
of
mortality
worldwide.
Despite
significant
advancements
in
cancer
research,
our
understanding
its
complex
developmental
pathways
inadequate.
Recent
research
has
clarified
the
intricate
relationship
between
central
nervous
system
(CNS)
and
cancer,
particularly
how
CNS
influences
tumor
growth
metastasis
via
regulating
immune
cell
activity.
The
interactions
cells
regulate
microenvironment
various
signaling
pathways,
cytokines,
neuropeptides,
neurotransmitters,
while
also
incorporating
processes
that
alter
immunological
landscape.
Furthermore,
therapeutic
strategies
targeting
neuro-immune
interactions,
such
as
checkpoint
inhibitors,
alongside
advanced
technologies
like
brain-computer
interfaces
nanodelivery
systems,
exhibit
promise
improving
treatment
efficacy.
This
bidirectional
regulatory
network
significantly
affects
development,
metastasis,
patient
status,
therapy
responses.
Therefore,
mechanisms
CNS-immune
is
crucial
for
developing
innovative
strategies.
work
consolidates
evaluates
their
potential
strategies,
provides
insights
future
approaches.
Frontiers in Neuroscience,
Journal Year:
2025,
Volume and Issue:
19
Published: Feb. 28, 2025
Introduction
The
gastrointestinal
tract
is
the
organ
most
extensively
distributed
by
autonomic
nerves,
and
researches
have
indicated
a
relationship
between
automatic
nerves
progression
of
cancers.
This
study
aimed
to
evaluate
nervous
function
in
patients
with
cancer
explore
its
clinical
characteristics.
Methods
We
employed
Composite
Autonomic
Symptom
Score
31
(COMPASS-31)
questionnaire
cardiovascular
reflex
tests
(CARTs)
function,
while
also
conducting
thorough
analysis
data.
Results
Our
results
showed
that
low
white
blood
cell
(WBC)
count
(OR
=
0.461,
95%
CI:
0.218–0.976,
p
0.043)
increased
maximum
tumor
diameter
1.619,
1.025–2.555,
0.039)
were
risk
factors
for
dysfunction
according
COMPASS-31
assessment.
While
hypertension
5.747,
1.186–27.862,
0.030)
elevated
platelet-to-albumin
ratio
(PAR)
1.256,
1.025–1.540,
0.028)
identified
as
independent
based
on
CARTs
results.
Combining
findings
from
revealed
older
age
1.133,
1.015–1.264,
0.027)
vascular
invasion
7.706,
1.391–42.684,
0.019)
dysfunction.
Conclusion
reveal
these
specific
related
cancers
significantly
influence
function.
It
essential
associated
malignancies,
which
provide
new
insights
into
intervention
strategies
diseases.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(7), P. 3057 - 3057
Published: March 27, 2025
Tumor
innervation
is
a
complex
interaction
between
nerves
and
cancer
cells
that
consists
of
axons
invading
tumors,
its
complexity
remains
largely
unknown
in
humans.
Although
some
retrospective
studies
have
provided
important
insights
into
the
relationship
further
knowledge
required
about
this
biological
process.
Animal
experiments
elucidated
several
molecular
cellular
mechanisms
tumor
innervation;
however,
no
experimental
models
currently
exist
to
study
interactions
human
nerve
cells.
Human
pluripotent
stem
can
differentiate
neurons
for
research
purposes;
use
these
with
unexplored.
Hence,
here
we
analyze
potential
derived
from
unravel
poorly
understood
innervation.
GeroScience,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 8, 2025
Abstract
Delaying
the
initiation
of
cancer
treatment
increases
risk
mortality,
particularly
in
colorectal
(CRC),
which
is
among
most
common
and
deadliest
malignancies.
This
study
aims
to
explore
impact
delays
on
mortality
CRC.
A
systematic
literature
search
was
conducted
PubMed,
Web
Science,
Scopus
for
studies
published
between
2000
2025.
Meta-analyses
were
performed
using
random-effects
models
with
inverse
variance
method
calculate
hazard
ratios
(HRs)
both
overall
cancer-specific
survival
at
4-,
8-,
12-week
delay
intervals,
heterogeneity
assessed
through
I
2
-statistics
publication
bias
evaluated
funnel
plots
Egger’s
test.
total
20
relevant
included
meta-analysis.
The
analyses
all
patients
demonstrated
a
progressively
increasing
12–39%
longer
(4
weeks,
HR
=
1.12;
95%
CI,
1.08–1.16;
8
1.24;
1.16–1.34;
12
1.39;
1.25–1.55).
In
particular,
incrementally
higher
observed
all–cause
4
weeks
(HR
1.14;
1.09–1.18),
1.29;
1.20–1.39),
1.47;
1.31–1.64).
contrast,
analysis
showed
similar
trend
but
did
not
reach
statistical
significance
1.07;
0.98–1.18;
1.15;
0.95–1.39;
1.23;
0.93–1.63).
Treatment
associated
worsening
survival,
each
4-week
increment
leading
substantially
risk.
suggests
that
timely
should
be
prioritized
clinical
practice,
as
these
efforts
can
lead
substantial
improvements
rates.
Archives of Dermatological Research,
Journal Year:
2025,
Volume and Issue:
317(1)
Published: April 12, 2025
CSCC
(cutaneous
squamous
cell
carcinoma)
of
the
face/scalp
generally
has
a
favorable
outcome.
However,
patients
with
delayed
regional
metastasis
from
scalp/facial
do
very
poorly.
Historically,
prophylactic
treatment
N0
neck
for
T1-T2
(as
staged
in
AJCC
7th
edition)
cancers
not
been
recommended.
This
study
aims
to
determine
predictors
metastases
<
4
cm
face
and
scalp.
We
retrospectively
analyzed
medical
records
diagnosed
scalp/face
at
least
6
months
after
diagnosis
primary
tertiary
academic
head
clinic
during
period
between
2012
2018.
A
total
50
were
treated
cervical
lymph
node
6-year
period.
All
male.
Areas
affected
scalp,
cheeks,
forehead.
No
patient
had
initial
presentation
their
cancer.
The
presence
perineural
invasion
tumor
was
only
observed
predictor
recurrence.
did
observe
an
association
diameter/depth
skin
or
lymphovascular
In
our
review,
(PNI)
one
factor
predictive
metastasis.
observation
confirms
use
PNI
upstage
even
small
T3.
Prophylactic
should
be
strongly
considered,
especially
age
immunotherapy.
BMC Cancer,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: April 15, 2025
Colorectal
cancer
(CRC)
is
the
most
prevalent
malignant
tumor
of
digestive
system
globally,
ranking
third
in
incidence
and
second
mortality.
In
previous
studies,
rate
lymph
node
metastasis
(LNM)
T2
CRC
ranged
from
18.0
to
28.0%.
We
aim
identify
patients
without
LNM
thereby
mitigate
complications
potential
impact
on
quality
life
associated
with
surgery.
this
retrospective
study,
787
cases
were
selected.
The
preoperative
postoperative
clinicopathological
features
retrospectively
studied.
Univariate
analysis
multivariate
performed
using
binary
logistic
regression
determine
predictive
factor
for
LNM.
Odds
ratio
(OR)
95%
confidence
interval
(CI)
conducted.
184
(23.4%)
diagnosed
LNM,
including
144
(78.3%)
N1stage
40
(21.7%)
N2
stage.
According
univariate
analysis,
poorly
differentiated
tumors
(p
=
0.003,
OR
4.405,
95%CI:
1.632-11.893),
perineural
invasion
0.001,
4.789,
1.958-11.716),
lymphovascular
2.779,
1.497-5.159)
independent
risk
factors
while
male
0.017,
0.652,
0.459-0.926)
elevated
PLR
0.048,
0.996,
0.993-1.000)
seemed
be
protective
factors.
Larger
size
did
not
show
significant
association
Approximately
three-quarters
are
likely
avoid
unnecessary
Female,
tumors,
invasion,
expected
used
as
predictors
CRC.
