Encapsulation of Sulforaphane from Cruciferous Vegetables in mPEG-PLGA Nanoparticles Enhances Cadmium’s Inhibitory Effect on HepG2 Cells

Nanomaterials, Journal Year: 2025, Volume and Issue: 15(8), P. 615 - 615

Published: April 16, 2025

Sulforaphane (SFN) is a natural isothiocyanate compound with multiple bioactive effects, abundantly found in cruciferous vegetables. SFN and cadmium (Cd) were limited their application as chemotherapeutic agents due to insufficient cellular uptake, low bioavailability, high systemic toxicity, respectively. In this study, mPEG-PLGA nanoparticles used carrier load Cd-γ-PGA conjugates SFN, enabling favorable drug release under acidic microenvironments excellent pH responsiveness. The NP-Cd-SFN exhibited particle size of 102.1 nm, zeta potential -14.48 mV, PDI value 0.257. These characteristics contribute the nanoparticles’ prolonged circulation bloodstream ability passively target tumors. Compared single-dose groups combined Cd + group, group significantly reduced viability HepG2 cells increased apoptosis rate by inducing mitochondrial oxidative stress promoting cell apoptosis. Overall, addition encapsulation enhanced therapeutic effects on cells.

Language: Английский

Selenium alleviates the effects of cadmium on growth performance, oxidative stress, cholesterol synthesis and ferroptosis of hybrid yellow catfish, Pelteobagrus fulvidraco ♀ × Pelteobagrus vachelli ♂

Published: Jan. 1, 2025

Language: Английский