Journal of Electroanalytical Chemistry, Journal Year: 2022, Volume and Issue: 910, P. 116182 - 116182
Published: March 1, 2022
Language: Английский
TrAC Trends in Analytical Chemistry, Journal Year: 2022, Volume and Issue: 157, P. 116735 - 116735
Published: July 12, 2022
Language: Английский
Citations
78
Biosensors, Journal Year: 2024, Volume and Issue: 14(7), P. 356 - 356
Published: July 22, 2024
The steady progress in consumer electronics, together with improvement microflow techniques, nanotechnology, and data processing, has led to implementation of cost-effective, user-friendly portable devices, which play the role not only gadgets but also diagnostic tools. Moreover, numerous smart devices monitor patients' health, some them are applied point-of-care (PoC) tests as a reliable source evaluation patient's condition. Current practices still based on laboratory tests, preceded by collection biological samples, then tested clinical conditions trained personnel specialistic equipment. In practice, collecting passive/active physiological behavioral from patients real time feeding artificial intelligence (AI) models can significantly improve decision process regarding diagnosis treatment procedures via omission conventional sampling while excluding pathologists. A combination novel methods digital traditional biomarker detection portable, autonomous, miniaturized revolutionize medical diagnostics coming years. This article focuses comparison modern techniques AI machine learning (ML). presented technologies will bypass laboratories start being commercialized, should lead or substitution current Their application PoC settings technology accessible every patient appears be possibility. Research this field is expected intensify Technological advancements sensors biosensors anticipated enable continuous real-time analysis various omics fields, fostering early disease intervention strategies. integration health platforms would predictive personalized healthcare, emphasizing importance interdisciplinary collaboration related scientific fields.
Language: Английский
Citations
31
Biosensors, Journal Year: 2024, Volume and Issue: 14(6), P. 277 - 277
Published: May 28, 2024
Biosensors function as sophisticated devices, converting biochemical reactions into electrical signals. Contemporary emphasis on developing biosensor devices with refined sensitivity and selectivity is critical due to their extensive functional capabilities. However, a significant challenge lies in the binding affinity of biosensors biomolecules, requiring adept conversion amplification interactions various signal modalities like electrical, optical, gravimetric, electrochemical outputs. Overcoming challenges associated sensitivity, detection limits, response time, reproducibility, stability essential for efficient creation. The central aspect fabrication any focused towards forming an effective interface between analyte electrode which significantly influences overall quality. Polymers macromolecular systems are favored distinct properties versatile applications. Enhancing conductivity these can be achieved through incorporating nanoparticles or carbonaceous moieties. Hybrid composite materials, possessing unique combination attributes advanced selectivity, thermal stability, mechanical flexibility, biocompatibility, tunable properties, emerge promising candidates In addition, this approach enhances response, amplification, fabricated biosensors, contributing effectiveness. This review predominantly explores recent advancements utilizing macrocyclic conjugated systems, such phthalocyanines, porphyrins, polymers, etc. hybrids, specific focus biosensors. It comprehensively covers synthetic strategies, working mechanisms, potential detecting biomolecules glucose, hydrogen peroxide, uric acid, ascorbic dopamine, cholesterol, amino acids, cancer cells. Furthermore, delves progress made, elucidating mechanisms responsible amplification. Conclusion addresses future directions macromolecule-based hybrids applications, providing concise overview evolving field. narrative emphasizes importance technology advancement, illustrating role smart design material enhancement improving performance across domains.
Language: Английский
Citations
30
Bioelectrochemistry, Journal Year: 2024, Volume and Issue: 157, P. 108671 - 108671
Published: Feb. 22, 2024
Language: Английский
Citations
25
ECS Sensors Plus, Journal Year: 2024, Volume and Issue: 3(2), P. 025001 - 025001
Published: May 7, 2024
Originating at the intersection of physics and biosensing, quantum biosensors (QB) are transforming medical diagnostics personalized medicine by exploiting phenomena to amplify sensitivity, specificity, detection speed compared traditional biosensors. Their foundation lies in fusion biological entities like DNA, proteins, or enzymes with sensors, which elicits discernible alterations light emissions when interacting sample molecules. prowess identifying disease-linked biomarkers presents an avenue for early diagnoses conditions Alzheimer’s cancer. Beyond this, they enable real-time monitoring treatment responses capturing dynamism biomarkers, but QB still faces challenges, such as issues stability, reproducibility, intricate interactions. Moreover, seamless integration into prevailing diagnostic frameworks necessitates careful consideration. Looking ahead, evolution navigates uncharted territories. Innovations fabrication techniques, interdisciplinary collaborations, standardization protocols emerge pivotal areas exploration. This comprehensive discourse encapsulates QB’s principles, diverse iterations, burgeoning utilities. It delves inherent challenges limitations, shedding on potential trajectories future research. As continues evolve, its redefine becomes increasingly tangible. The saga resonates possibilities, poised reshape landscape profoundly.
Language: Английский
Citations
20
Digital Discovery, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
AI-integrated electrochemical sensors boost peak resolution and sensitivity, enabling precise detection of electroactive species in complex matrices. This method enhances analytical capabilities, providing an analytically robust solution.
Language: Английский
Citations
2
Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: March 9, 2025
Early and precise diagnosis of neurodegenerative disorders like Alzheimer's (AD) Parkinson's (PD) is crucial for slowing their progression enhancing patient outcomes. Exosomal microRNAs (miRNAs) are emerging as promising biomarkers due to ability reflect the diseases' pathology, yet low abundance poses significant detection hurdles. This review article delves into burgeoning field electrochemical biosensors, designed exosomal miRNA biomarkers. Electrochemical biosensors offer a compelling solution, combining sensitivity required detect low-abundance with specificity needed discern profiles distinctive neural pathological states. We explore operational principles these including transduction mechanisms that facilitate detection. The also summarizes advancements in nanotechnology, signal enhancement, bioreceptor anchoring, microfluidic integration improve sensor accuracy. evidence use disease analyzed, focusing on clinical impact, diagnostic precision, obstacles faced practical applications. Their potential point-of-care testing regulatory considerations market entry discussed. Looking toward future, highlights forthcoming innovations might revolutionize early processes. impressive sensitivity, specificity, compatibility, track become instrumental diseases, possibly transforming care prognosis.
Language: Английский
Citations
2
Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 61(50)
Published: Sept. 30, 2022
Nucleic acids are remarkable molecules. In addition to Watson-Crick base pairing, the different structural motifs of these molecules can bind non-nucleic acid targets or catalyze chemical reactions. Additionally, nucleic easily modified with functional groups. These properties make acids, particularly DNA, ideally suited for use in electrochemical biosensors, both as biorecognition elements and redox reporter probes. this Minireview, we will review historical evolution probes biosensors. We then specific examples nucleic-acid-based biosensors that have been evaluated clinical areas infectious disease, cancer, cardiovascular health.
Language: Английский
Citations
54
Biosensors, Journal Year: 2023, Volume and Issue: 13(3), P. 398 - 398
Published: March 18, 2023
Cancer is one of the major public health issues in world. It has become second leading cause death, with approximately 75% cancer deaths transpiring low- or middle-income countries. causes a heavy global economic cost estimated at more than trillion dollars per year. The most common cancers are breast, colon, rectum, prostate, and lung cancers. Many these can be treated effectively cured if detected primary stage. Nowadays, around 50% late stages, to serious complications death. Early diagnosis diseases substantially increases efficient treatment high chances survival. Biosensors potential screening methodologies useful early biomarkers. This review summarizes recent findings about novel biomarkers their advantages over traditional biomarkers, biosensing diagnostic methods for them; thus, this may helpful recognition monitoring response various human
Language: Английский
Citations
31
3 Biotech, Journal Year: 2023, Volume and Issue: 13(5)
Published: April 27, 2023
Language: Английский
Citations
27