Emerging Non-invasive Brain Stimulations for Schizophrenia DOI
Xiyu Wang,

Daniel M. Blumberger,

Plabon Ismail

et al.

Royal Society of Chemistry eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 156 - 184

Published: Dec. 6, 2024

Non-invasive brain stimulation (NIBS) encompasses a variety of techniques that modulate activity transcranially, including transcranial current (tCS), magnetic (TMS), seizure therapy (MST), vagus nerve (VNS), and ultrasound (TUS). These modalities are now extensively studied for their applications in various neuropsychiatric conditions, notably schizophrenia. In general, NIBS serves dual roles As probe, it offers insights into cortical reactivity, connectivity, oscillations, elucidating the disorder’s pathophysiology. treatment, has shown promise alleviating positive symptoms (e.g. auditory hallucinations), negative symptoms, cognitive deficits. While clinical outcomes vary, ongoing research aims to optimize parameters identify patient-specific predictors response. The integration therapeutic strategies schizophrenia is cautiously optimistic, highlighting its potential as transformative approach treatment.

Language: Английский

Non-invasive brain stimulation in cognitive sciences and Alzheimer's disease DOI Creative Commons
Claudia Carrarini, Chiara Pappalettera,

Domenica Le Pera

et al.

Frontiers in Human Neuroscience, Journal Year: 2025, Volume and Issue: 18

Published: Jan. 14, 2025

Over the last four decades, non-invasive brain stimulation techniques (NIBS) have significantly gained interest in fields of cognitive sciences and dementia care, including neurorehabilitation, for its emerging potential increasing insights over functions boosting residual functions. In present paper, basic physiological technical mechanisms different applications NIBS were reviewed discussed to highlight importance multidisciplinary translational approaches clinical research settings neurodegenerative diseases, especially Alzheimer's disease. Indeed, strategies may represent a promising opportunity increase neuromodulation as efficacious interventions individualized patients care.

Language: Английский

Citations

2

The case for hemispheric lateralization of the human amygdala in fear processing DOI Creative Commons
Tao Xie, Sanne J.H. van Rooij, Cory S. Inman

et al.

Molecular Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

The amygdala has increasingly been proposed as a therapeutic target for patients with post-traumatic stress disorder (PTSD). However, the distinct contributions of left and right to various aspects fear processing remain inadequately understood. Here, we critically re-evaluate key findings from human functional neuroimaging lesion studies on conditioning extinction. We propose that while both amygdalae likely make critical processing, is more associated sensory-mediated expression, cognitive-mediated acquisition With accumulating evidence studies, suggest differentially targeting versus ablative or neuromodulatory therapies can be crucial optimizing PTSD treatment.

Language: Английский

Citations

2

MRI Free Targeting of Deep Brain Structures in the Anterior Cingulate Cortex Using Facial Landmarks DOI Creative Commons
Thomas Riis,

Seth Lunt,

Jan Kubanek

et al.

Brain stimulation, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0

Focused Ultrasound Neuromodulation: Exploring a Novel Treatment for Severe Opioid Use Disorder DOI
Ali R. Rezai, Daisy G.Y. Thompson-Lake, Pierre-François D’Haese

et al.

Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0

Transcranial Focused Ultrasound Stimulation in Dynamic Clinical Settings: Initial Strategy in Schizophrenia and Status Epilepticus DOI
Spencer T. Brinker, Wei Qi, David King‐Stephens

et al.

Ultrasound in Medicine & Biology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0

Novel NIBS in psychiatry: Unveiling TUS and TI for research and treatment DOI Creative Commons
F Sharif, Catherine J. Harmer, Miriam C. Klein-Flügge

et al.

Brain and Neuroscience Advances, Journal Year: 2025, Volume and Issue: 9

Published: March 1, 2025

Mental disorders pose a significant global burden and constitute major cause of disability worldwide. Despite strides in treatment, substantial number patients do not respond adequately, underscoring the urgency for innovative approaches. Traditional non-invasive brain stimulation techniques show promise, yet grapple with challenges regarding efficacy specificity. Variations mechanistic understanding reliability among methods are common, limited spatial precision physical constraints hindering ability to target subcortical areas often implicated disease aetiology. Novel such as transcranial ultrasonic temporal interference have gained notable momentum recent years, possibly addressing these shortcomings. Transcranial (TUS) offers exceptional deeper penetration compared conventional electrical magnetic techniques. Studies targeting diverse array regions shown its potential affect neuronal excitability, functional connectivity symptoms psychiatric depressive disorder. Nevertheless, planning acoustic interactions skull must be tackled widespread adoption research potentially clinical settings. Similar stimulation, (TI) traditional albeit requiring comparatively higher current equivalent neural effects. Promising still sparse highlights TI’s selectively modulate activity, showing utility psychiatry. Overall, like only open new avenues but also hold effective treatments However, realising their full necessitates practical optimising application effectively.

Language: Английский

Citations

0

The Exciting Frontier of Neuroplasticity: Innovations in Brain Health and Recovery DOI Open Access
Ramendra N. Saha

Journal of Behavioral and Brain Science, Journal Year: 2025, Volume and Issue: 15(03), P. 47 - 80

Published: Jan. 1, 2025

Language: Английский

Citations

0

Computational sensitivity evaluation of ultrasound neuromodulation resolution to brain tissue sound speed with robust beamforming DOI Creative Commons
Boqiang Fan, Wayne K. Goodman, Sameer A. Sheth

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 2, 2025

Low-intensity focused ultrasound (LIFU) neuromodulation requires precise targeting and high resolution enabled by phased array transducers beamforming. However, focusing optimization usually relies on phantom measurements or simulations with inaccurate acoustic properties to degrade resolution. Therefore, this work analyzes the sensitivity of resolution, measured off-target activation area (OTAA), brain tissue sound speed. A Robust Optimal Resolution (ROR) beamforming method is proposed minimize worst-case OTAA restricted speed inaccuracy propagation information estimated deviated The estimation model utilizes equivalent source (ESM) map field between different parameter sets. Simulation in a human head validates effectiveness model, shows that ROR can significantly reduce compared benchmark methods [Formula: see text] average up text], improving robustness stimulation addressing issue. This allows reliable high-resolution potential clinical applications reduced invasive acquisition for optimization.

Language: Английский

Citations

0

Non-invasive brain stimulation to modulate neural activity in Parkinson’s disease DOI Creative Commons
Manuel Bange, Rick C. Helmich, Aparna Wagle Shukla

et al.

npj Parkinson s Disease, Journal Year: 2025, Volume and Issue: 11(1)

Published: April 5, 2025

Despite its potential to modulate brain and network activity, non-invasive stimulation is not yet clinically applied for treating Parkinson's disease. We here review recent findings that illustrate how various techniques can modify pathological compensatory activities. Due unavoidable heterogeneities low effect sizes of the reviewed studies, a deeper understanding mechanisms action will be critical refining clinical effectiveness generating consistent results.

Language: Английский

Citations

0

Repeated neuromodulation with low-intensity focused ultrasound in patients with Alzheimer's disease DOI
Hyeonseok Jeong,

Doyu Kim,

Seunghee Na

et al.

Journal of Alzheimer s Disease, Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

Background Low-intensity focused ultrasound (LIFU), a non-invasive targeted brain stimulation technology, has shown promise for therapeutic applications in Alzheimer's disease (AD) patients. Despite its potential, the implications of repeated LIFU neuromodulation AD patients remain to be investigated. Objective This pilot study evaluated safety and potential improve cognition functional connectivity following treatment Methods Ten early-stage underwent six sessions neuronavigation-guided targeting left dorsolateral prefrontal cortex (DLPFC) within 2–3 weeks, alongside ongoing standard pharmacotherapy. Neuropsychological assessments resting-state magnetic resonance imaging were performed at baseline eight weeks post-treatment. Results Memory performance (p = 0.02) between DLPFC both perirhinal dorsomedial (corrected p < 0.05) significantly improved from baseline. Additionally, enhancements memory positively correlated with increases (Kendall's tau 0.56, 0.03). No adverse events reported during treatments or subsequent follow-up. Conclusions may have enhance network functions Our results provide basis further research, including randomized sham-controlled trials optimization protocols, on as supplementary alternative option AD. Trial registration Clinical Research Information Service, KCT0008169, Registered 10 February 2023

Language: Английский

Citations

0