Propolis: Its Role and Efficacy in Human Health and Diseases

Molecules, Journal Year: 2022, Volume and Issue: 27(18), P. 6120 - 6120

Published: Sept. 19, 2022

With technological advancements in the medicinal and pharmaceutical industries, numerous research studies have focused on propolis produced by stingless bees (Meliponini tribe) Apis mellifera honeybees as alternative complementary medicines for potential treatment of various acute chronic diseases. Propolis can be found tropical subtropical forests throughout world. The composition phytochemical constituents varies depending bee species, geographical location, botanical source, environmental conditions. Typically, contains lipid, beeswax, essential oils, pollen, organic components. latter include flavonoids, phenolic compounds, polyphenols, terpenes, terpenoids, coumarins, steroids, amino acids, aromatic acids. biologically active propolis, which countless compounds such artepillin C, caffeic acid, acid phenethyl ester, apigenin, chrysin, galangin, kaempferol, luteolin, genistein, naringin, pinocembrin, coumaric quercetin, a broad spectrum biological therapeutic properties antidiabetic, anti-inflammatory, antioxidant, anticancer, rheumatoid arthritis, obstruct pulmonary disorders, cardiovascular diseases, respiratory tract-related gastrointestinal well neuroprotective, immunomodulatory, immuno-inflammatory agents. Therefore, this review aims to provide summary recent role its constituents, their efficacy

Language: Английский

---

Perspectives for Uses of Propolis in Therapy against Infectious Diseases

Molecules, Journal Year: 2022, Volume and Issue: 27(14), P. 4594 - 4594

Published: July 19, 2022

Propolis has gained wide popularity over the last decades in several parts of world. In parallel, literature about propolis composition and biological properties increased markedly. A great number papers have demonstrated that from different world is composed mainly phenolic substances, frequently flavonoids, derived plant resins. a relevant role increasing social immunity bee hives. Experimental evidence indicates its components activity against bacteria, fungi, viruses. Mechanisms action on viruses are known for components. Experiments shown may act synergistically with antibiotics, antifungals, antivirus drugs, permitting administration lower doses drugs higher antimicrobial effects. The current trend growing resistance microbial pathogens to available encouraged introduction therapy infectious diseases. Because widely variable, standardized extracts been produced. Successful clinical trials included as medicine dentistry an adjuvant treatment patients COVID-19. Present health conditions encourage initiatives toward spread niche propolis, not only traditional alternative but also protagonist anti-infectious therapy. Production other apiary products environmentally friendly contribute alleviating crisis decline populations. production had social-economic relevance Brazil, providing benefits underprivileged people.

Language: Английский

---

Natural antibiotics against antimicrobial resistance: sources and bioinspired delivery systems

Brazilian Journal of Microbiology, Journal Year: 2024, Volume and Issue: 55(3), P. 2753 - 2766

Published: June 18, 2024

The current burden associated to multidrug resistance, and the emerging superbugs, result in a decreased even loss of antibiotic efficacy, which poses significant challenges treatment infectious diseases. This situation has created high demand for discovery novel antibiotics that are both effective safe. However, while play crucial role preventing treating diseases, they also with adverse effects. emergence multidrug-resistant extensive appearance drug-resistant microorganisms, become one major hurdles healthcare. Addressing this problem will require development at least 20 new by 2060. process designing is time-consuming. To overcome spread microbes infections, constant evaluation innovative methods molecules essential. Research actively exploring alternative strategies, such as combination therapies, drug delivery systems, repurposing existing drugs. In addition, advancements genomic proteomic technologies aiding identification potential targets compounds. review, we explore sources natural from plants, algae other sources, propose bioinspired systems their use an approach promoting responsible mitigate infections.

Language: Английский

---

Effect of propolis on mood, quality of life, and metabolic profiles in subjects with metabolic syndrome: a randomized clinical trial

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: March 17, 2023

Abstract Metabolic syndrome (MeS) is a common multifaceted disorder. Plants contain antioxidant bioactive compounds, which are beneficial to improve the health condition of patients with MeS. Propolis hive natural product that composed various constituent. We aimed assess effects Iranian propolis as and safe agent on indicators MeS, quality life mood status in individuals In total, 66 interested eligible recruited present study. Participants were randomly assigned consume tablet at dose 250 mg extract, twice daily for 12 weeks or placebo. supplementation could lead significant reduction waist circumference (WC), increase physical functioning, general overall score SF-36 compared placebo group (P-value < 0.05). However, no differences observed regarding other anthropometric indices biochemical parameters between two groups > The current study indicated can be effective decreasing WC improving life, while had components MeS among subjects this syndrome. Clinical trials registration Iran Registry Trials.ir IRCT20121216011763N49, date 23/12/2020.

Language: Английский

---

Chemical characterization and antibacterial activities of Brazilian propolis extracts from Apis mellifera bees and stingless bees (Meliponini)

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(7), P. e0307289 - e0307289

Published: July 16, 2024

The aim of this study was to evaluate the physicochemical composition and antibacterial activity Brazilian propolis extracts from different types, concentrations, extraction solvents regions in Brazil. A total 21 samples were analyzed, comprising 14 Apis mellifera (12 green, 1 brown, red) 7 stingless bees (3 mandaçaia, 2 jataí, hebora, tubuna). analyses performed dry extract, phenolic content (TPC) antioxidant (DPPH ABTS). by Determination Minimal Inhibitory Concentration (MIC) Bactericidal (MBC). results showed that very low levels compounds decreased antimicrobial tubuna jataí. However, there no correlation between increase concentration activity. highest TPC obtained for green extract made with 70% raw presented similar formulated 30% or less propolis. aqueous lower compared alcoholic extracts, indicating ethanol is a better solvent extracting active It observed MIC (0.06 0.2 mg/mL) MBC (0.2 0.5 values Gram-negative bacteria higher Gram-positive (MIC 0.001-0.2 mg/mL, 0.02-0.5 mg/mL). exhibited activities hebora Distrito Federal (DF) mandaçaia Santa Catarina, showing comparable efficacy 5, 6, 7, which DF. Hence, these products can be considered an excellent source bioactive potential utilization both pharmaceutical food industries.

Language: Английский

---

Synergistic Effect of Polyphenol-Rich Complex of Plant and Green Propolis Extracts with Antibiotics against Respiratory Infections Causing Bacteria

Antibiotics, Journal Year: 2022, Volume and Issue: 11(2), P. 160 - 160

Published: Jan. 26, 2022

Bacterial infections are a prevalent complication after primary viral respiratory and associated with high morbidity mortality. Antibiotics widely used against bacterial pathogens; however, the rise in antibiotic-resistant strains urges us to search for new antimicrobial compounds, including ones that act synergistically antibiotics. In this study, minimal inhibitory (MIC) bactericidal (MBC) concentrations of polyphenol-rich complex green propolis, Tabebuia avellanedae bark, Olea europaea leaf extracts Staphylococcus aureus, Haemophilus influenzae, Klebsiella pneumoniae were determined, followed by an analysis synergistic effect clarithromycin, azithromycin, amoxiclav (875/125 mg amoxicillin/clavulanic acid). A combination showed activity all three strains, MIC values ranging from 0.78 12.5 mg/mL MBC 1.56 mg/mL. The azithromycin clarithromycin S. K. pneumoniae, tested antibiotics H. influenzae. Synergy was additionally evaluated time-kill assay where effects aureus seen within first 6 h incubation. results show potential enhancing efficacy antibiotic therapy indicate their be management infections.

Language: Английский

---

Food-grade delivery systems of Brazilian propolis from Apis mellifera: From chemical composition to bioactivities in vivo

Food Chemistry, Journal Year: 2023, Volume and Issue: 432, P. 137175 - 137175

Published: Aug. 18, 2023

Brazilian propolis from Apis mellifera is widely studied worldwide due to its unique chemical composition and biological properties, such as antioxidant, antimicrobial, anti-inflammatory. However, although many countries produce honey, another bee product, the consumption of a functional ingredient linked hydroethanolic extract. Hence, other food uses still have be incorporated into systems. Assuming that rich source flavonoids regarded food-grade for pharmaceutical applications, this review provides theoretical practical basis optimising bioactive properties propolis, encompassing extraction processes incorporating compounds in delivery systems applications. Overall, pharmacotechnical resources can optimise enhance stability phenolic ensure bioactivity formulations.

Language: Английский

---

Comparison of patch testing Brazilian (Green) propolis and Chinese (poplar‐type) propolis: Clinical epidemiological study using data from the Information Network of Departments of Dermatology (IVDK)

Contact Dermatitis, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 5, 2024

Abstract Background Propolis types differ regarding their chemical composition. Objectives To compare patch test results based on Brazilian (Green) propolis with data Chinese (poplar‐type) propolis, and to evaluate the specifications of raw materials used for PT preparations. Methods In Information Network Departments Dermatology (IVDK), 1290 consecutive patients were tested (NH400, SmartPractice Europe). Patch reactivity was compared obtained (NA71, Europe) by calculating frequencies corresponding 95% confidence intervals. Data NH400 NA71 from manufacturer. Results Positive reactions found in 303 (23.5%) unclear clinical relevance most cases. Patients reacting less often sensitised fragrances colophony, but more nickel sulphate cobalt chloride than NA71. The batch contained high levels aerobic bacteria, not purified ethanolic extraction. Conclusions Pattern concomitant along material properties suggests that frequency positive may primarily result bacterial contamination or impurities preparation rather constituents.

Language: Английский

---

Quality assessment and chemical diversity of Australian propolis from Apis mellifera bees

Scientific Reports, Journal Year: 2022, Volume and Issue: 12(1)

Published: Aug. 9, 2022

Abstract The propolis industry is well established in European, South American and East Asian countries. Within Australia, this beginning to emerge with a few small-scale producers. To contribute the development of Australian industry, present study aimed examine quality chemical diversity collected from various regions across Australia. results testing 158 samples indicated that had pure resin yielding 2 81% by weight, total phenolic content flavonoid one gram dry extract ranging up 181 mg gallic acid equivalent 145 quercetin equivalent, respectively. Some showed more potent antioxidant activity than well-known Brazilian green, red, Uruguayan New Zealand poplar-type an vitro DPPH assay. In addition, HPLC–UV analysis resulted identification 16 types which can be considered as high-grade owing their high content. Chemometric 1 H NMR spectra revealed originating eastern western coasts Australia could significantly discriminated based on composition.

Language: Английский

---

Brazilian Amazon Red Propolis: Leishmanicidal Activity and Chemical Composition of a New Variety of Red Propolis

Metabolites, Journal Year: 2023, Volume and Issue: 13(9), P. 1027 - 1027

Published: Sept. 21, 2023

Leishmaniasis is caused by protozoans of the genus Leishmania, and its treatment highly toxic, leading to discontinuation emergence resistant strains. In this study, we assessed leishmanicidal activity chemical composition red propolis collected from Amazon-dominated region northern Tocantins State, Brazil. The MTT assay was employed determine samples’ against Leishmania amazonensis promastigotes their cytotoxicity RAW macrophages. Spectrophotometric assays were utilised measure concentrations total phenolics flavonoids, while high-performance liquid chromatography coupled a mass spectrometer (LC-MS/MS) used composition. An in silico study conducted evaluate which compounds Brazilian Amazon may correlate with biological activity. exhibited high concentration phenolic an inhibitory L. amazonensis, IC50 ranging 23.37 36.10 µg/mL. Moreover, fractionation yielded fraction enhanced bioactivity (16.11 µg/mL). Interestingly, neither nor most active showed towards macrophages at up 200 colour presence isoflavonoid components (isoflavones, isoflavans, pterocarpans) confirm that substance propolis. However, absence polyprenylated benzophenones suggests new variety performed two main drug targets using all identified reported liquiritigenin compound best electronic interaction parameters, confirmed standard. findings indicate possesses activity, low toxicity, significant biotechnological potential.

Language: Английский

---