Molecules,
Journal Year:
2022,
Volume and Issue:
27(7), P. 2206 - 2206
Published: March 28, 2022
The
chemical
composition
and
antimicrobial
activity
of
propolis
from
a
semi-arid
region
Morocco
were
investigated.
Fifteen
compounds,
including
triterpenoids
(1,
2,
7-12),
macrocyclic
diterpenes
ingol
type
(3-6)
aromatic
derivatives
(13-15),
isolated
by
various
chromatographic
methods.
Their
structures
elucidated
combination
spectroscopic
chiroptical
Compounds
1
3
are
new
natural
4-6,
9-11
newly
propolis.
Moreover,
the
full
nuclear
magnetic
resonance
(NMR)
assignments
three
known
compounds
(2,
4
5)
reported
for
first
time.
Most
tested,
especially
3,
4,
6,
exhibited
very
good
against
different
strains
bacteria
fungi.
Compound
showed
strongest
with
minimum
inhibitory
concentrations
(MICs)
in
range
4-64
µg/mL.
was
found
to
be
characteristic
Euphorbia
spp.,
officinarum
subsp.
echinus
could
suggested
as
probable
plant
source
Molecules,
Journal Year:
2022,
Volume and Issue:
27(18), P. 6120 - 6120
Published: Sept. 19, 2022
With
technological
advancements
in
the
medicinal
and
pharmaceutical
industries,
numerous
research
studies
have
focused
on
propolis
produced
by
stingless
bees
(Meliponini
tribe)
Apis
mellifera
honeybees
as
alternative
complementary
medicines
for
potential
treatment
of
various
acute
chronic
diseases.
Propolis
can
be
found
tropical
subtropical
forests
throughout
world.
The
composition
phytochemical
constituents
varies
depending
bee
species,
geographical
location,
botanical
source,
environmental
conditions.
Typically,
contains
lipid,
beeswax,
essential
oils,
pollen,
organic
components.
latter
include
flavonoids,
phenolic
compounds,
polyphenols,
terpenes,
terpenoids,
coumarins,
steroids,
amino
acids,
aromatic
acids.
biologically
active
propolis,
which
countless
compounds
such
artepillin
C,
caffeic
acid,
acid
phenethyl
ester,
apigenin,
chrysin,
galangin,
kaempferol,
luteolin,
genistein,
naringin,
pinocembrin,
coumaric
quercetin,
a
broad
spectrum
biological
therapeutic
properties
antidiabetic,
anti-inflammatory,
antioxidant,
anticancer,
rheumatoid
arthritis,
obstruct
pulmonary
disorders,
cardiovascular
diseases,
respiratory
tract-related
gastrointestinal
well
neuroprotective,
immunomodulatory,
immuno-inflammatory
agents.
Therefore,
this
review
aims
to
provide
summary
recent
role
its
constituents,
their
efficacy
Molecules,
Journal Year:
2022,
Volume and Issue:
27(14), P. 4594 - 4594
Published: July 19, 2022
Propolis
has
gained
wide
popularity
over
the
last
decades
in
several
parts
of
world.
In
parallel,
literature
about
propolis
composition
and
biological
properties
increased
markedly.
A
great
number
papers
have
demonstrated
that
from
different
world
is
composed
mainly
phenolic
substances,
frequently
flavonoids,
derived
plant
resins.
a
relevant
role
increasing
social
immunity
bee
hives.
Experimental
evidence
indicates
its
components
activity
against
bacteria,
fungi,
viruses.
Mechanisms
action
on
viruses
are
known
for
components.
Experiments
shown
may
act
synergistically
with
antibiotics,
antifungals,
antivirus
drugs,
permitting
administration
lower
doses
drugs
higher
antimicrobial
effects.
The
current
trend
growing
resistance
microbial
pathogens
to
available
encouraged
introduction
therapy
infectious
diseases.
Because
widely
variable,
standardized
extracts
been
produced.
Successful
clinical
trials
included
as
medicine
dentistry
an
adjuvant
treatment
patients
COVID-19.
Present
health
conditions
encourage
initiatives
toward
spread
niche
propolis,
not
only
traditional
alternative
but
also
protagonist
anti-infectious
therapy.
Production
other
apiary
products
environmentally
friendly
contribute
alleviating
crisis
decline
populations.
production
had
social-economic
relevance
Brazil,
providing
benefits
underprivileged
people.
Brazilian Journal of Microbiology,
Journal Year:
2024,
Volume and Issue:
55(3), P. 2753 - 2766
Published: June 18, 2024
The
current
burden
associated
to
multidrug
resistance,
and
the
emerging
superbugs,
result
in
a
decreased
even
loss
of
antibiotic
efficacy,
which
poses
significant
challenges
treatment
infectious
diseases.
This
situation
has
created
high
demand
for
discovery
novel
antibiotics
that
are
both
effective
safe.
However,
while
play
crucial
role
preventing
treating
diseases,
they
also
with
adverse
effects.
emergence
multidrug-resistant
extensive
appearance
drug-resistant
microorganisms,
become
one
major
hurdles
healthcare.
Addressing
this
problem
will
require
development
at
least
20
new
by
2060.
process
designing
is
time-consuming.
To
overcome
spread
microbes
infections,
constant
evaluation
innovative
methods
molecules
essential.
Research
actively
exploring
alternative
strategies,
such
as
combination
therapies,
drug
delivery
systems,
repurposing
existing
drugs.
In
addition,
advancements
genomic
proteomic
technologies
aiding
identification
potential
targets
compounds.
review,
we
explore
sources
natural
from
plants,
algae
other
sources,
propose
bioinspired
systems
their
use
an
approach
promoting
responsible
mitigate
infections.
Scientific Reports,
Journal Year:
2023,
Volume and Issue:
13(1)
Published: March 17, 2023
Abstract
Metabolic
syndrome
(MeS)
is
a
common
multifaceted
disorder.
Plants
contain
antioxidant
bioactive
compounds,
which
are
beneficial
to
improve
the
health
condition
of
patients
with
MeS.
Propolis
hive
natural
product
that
composed
various
constituent.
We
aimed
assess
effects
Iranian
propolis
as
and
safe
agent
on
indicators
MeS,
quality
life
mood
status
in
individuals
In
total,
66
interested
eligible
recruited
present
study.
Participants
were
randomly
assigned
consume
tablet
at
dose
250
mg
extract,
twice
daily
for
12
weeks
or
placebo.
supplementation
could
lead
significant
reduction
waist
circumference
(WC),
increase
physical
functioning,
general
overall
score
SF-36
compared
placebo
group
(P-value
<
0.05).
However,
no
differences
observed
regarding
other
anthropometric
indices
biochemical
parameters
between
two
groups
>
The
current
study
indicated
can
be
effective
decreasing
WC
improving
life,
while
had
components
MeS
among
subjects
this
syndrome.
Clinical
trials
registration
Iran
Registry
Trials.ir
IRCT20121216011763N49,
date
23/12/2020.
PLoS ONE,
Journal Year:
2024,
Volume and Issue:
19(7), P. e0307289 - e0307289
Published: July 16, 2024
The
aim
of
this
study
was
to
evaluate
the
physicochemical
composition
and
antibacterial
activity
Brazilian
propolis
extracts
from
different
types,
concentrations,
extraction
solvents
regions
in
Brazil.
A
total
21
samples
were
analyzed,
comprising
14
Apis
mellifera
(12
green,
1
brown,
red)
7
stingless
bees
(3
mandaçaia,
2
jataí,
hebora,
tubuna).
analyses
performed
dry
extract,
phenolic
content
(TPC)
antioxidant
(DPPH
ABTS).
by
Determination
Minimal
Inhibitory
Concentration
(MIC)
Bactericidal
(MBC).
results
showed
that
very
low
levels
compounds
decreased
antimicrobial
tubuna
jataí.
However,
there
no
correlation
between
increase
concentration
activity.
highest
TPC
obtained
for
green
extract
made
with
70%
raw
presented
similar
formulated
30%
or
less
propolis.
aqueous
lower
compared
alcoholic
extracts,
indicating
ethanol
is
a
better
solvent
extracting
active
It
observed
MIC
(0.06
0.2
mg/mL)
MBC
(0.2
0.5
values
Gram-negative
bacteria
higher
Gram-positive
(MIC
0.001-0.2
mg/mL,
0.02-0.5
mg/mL).
exhibited
activities
hebora
Distrito
Federal
(DF)
mandaçaia
Santa
Catarina,
showing
comparable
efficacy
5,
6,
7,
which
DF.
Hence,
these
products
can
be
considered
an
excellent
source
bioactive
potential
utilization
both
pharmaceutical
food
industries.
Antibiotics,
Journal Year:
2022,
Volume and Issue:
11(2), P. 160 - 160
Published: Jan. 26, 2022
Bacterial
infections
are
a
prevalent
complication
after
primary
viral
respiratory
and
associated
with
high
morbidity
mortality.
Antibiotics
widely
used
against
bacterial
pathogens;
however,
the
rise
in
antibiotic-resistant
strains
urges
us
to
search
for
new
antimicrobial
compounds,
including
ones
that
act
synergistically
antibiotics.
In
this
study,
minimal
inhibitory
(MIC)
bactericidal
(MBC)
concentrations
of
polyphenol-rich
complex
green
propolis,
Tabebuia
avellanedae
bark,
Olea
europaea
leaf
extracts
Staphylococcus
aureus,
Haemophilus
influenzae,
Klebsiella
pneumoniae
were
determined,
followed
by
an
analysis
synergistic
effect
clarithromycin,
azithromycin,
amoxiclav
(875/125
mg
amoxicillin/clavulanic
acid).
A
combination
showed
activity
all
three
strains,
MIC
values
ranging
from
0.78
12.5
mg/mL
MBC
1.56
mg/mL.
The
azithromycin
clarithromycin
S.
K.
pneumoniae,
tested
antibiotics
H.
influenzae.
Synergy
was
additionally
evaluated
time-kill
assay
where
effects
aureus
seen
within
first
6
h
incubation.
results
show
potential
enhancing
efficacy
antibiotic
therapy
indicate
their
be
management
infections.
Food Chemistry,
Journal Year:
2023,
Volume and Issue:
432, P. 137175 - 137175
Published: Aug. 18, 2023
Brazilian
propolis
from
Apis
mellifera
is
widely
studied
worldwide
due
to
its
unique
chemical
composition
and
biological
properties,
such
as
antioxidant,
antimicrobial,
anti-inflammatory.
However,
although
many
countries
produce
honey,
another
bee
product,
the
consumption
of
a
functional
ingredient
linked
hydroethanolic
extract.
Hence,
other
food
uses
still
have
be
incorporated
into
systems.
Assuming
that
rich
source
flavonoids
regarded
food-grade
for
pharmaceutical
applications,
this
review
provides
theoretical
practical
basis
optimising
bioactive
properties
propolis,
encompassing
extraction
processes
incorporating
compounds
in
delivery
systems
applications.
Overall,
pharmacotechnical
resources
can
optimise
enhance
stability
phenolic
ensure
bioactivity
formulations.
Contact Dermatitis,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 5, 2024
Abstract
Background
Propolis
types
differ
regarding
their
chemical
composition.
Objectives
To
compare
patch
test
results
based
on
Brazilian
(Green)
propolis
with
data
Chinese
(poplar‐type)
propolis,
and
to
evaluate
the
specifications
of
raw
materials
used
for
PT
preparations.
Methods
In
Information
Network
Departments
Dermatology
(IVDK),
1290
consecutive
patients
were
tested
(NH400,
SmartPractice
Europe).
Patch
reactivity
was
compared
obtained
(NA71,
Europe)
by
calculating
frequencies
corresponding
95%
confidence
intervals.
Data
NH400
NA71
from
manufacturer.
Results
Positive
reactions
found
in
303
(23.5%)
unclear
clinical
relevance
most
cases.
Patients
reacting
less
often
sensitised
fragrances
colophony,
but
more
nickel
sulphate
cobalt
chloride
than
NA71.
The
batch
contained
high
levels
aerobic
bacteria,
not
purified
ethanolic
extraction.
Conclusions
Pattern
concomitant
along
material
properties
suggests
that
frequency
positive
may
primarily
result
bacterial
contamination
or
impurities
preparation
rather
constituents.
Scientific Reports,
Journal Year:
2022,
Volume and Issue:
12(1)
Published: Aug. 9, 2022
Abstract
The
propolis
industry
is
well
established
in
European,
South
American
and
East
Asian
countries.
Within
Australia,
this
beginning
to
emerge
with
a
few
small-scale
producers.
To
contribute
the
development
of
Australian
industry,
present
study
aimed
examine
quality
chemical
diversity
collected
from
various
regions
across
Australia.
results
testing
158
samples
indicated
that
had
pure
resin
yielding
2
81%
by
weight,
total
phenolic
content
flavonoid
one
gram
dry
extract
ranging
up
181
mg
gallic
acid
equivalent
145
quercetin
equivalent,
respectively.
Some
showed
more
potent
antioxidant
activity
than
well-known
Brazilian
green,
red,
Uruguayan
New
Zealand
poplar-type
an
vitro
DPPH
assay.
In
addition,
HPLC–UV
analysis
resulted
identification
16
types
which
can
be
considered
as
high-grade
owing
their
high
content.
Chemometric
1
H
NMR
spectra
revealed
originating
eastern
western
coasts
Australia
could
significantly
discriminated
based
on
composition.
Metabolites,
Journal Year:
2023,
Volume and Issue:
13(9), P. 1027 - 1027
Published: Sept. 21, 2023
Leishmaniasis
is
caused
by
protozoans
of
the
genus
Leishmania,
and
its
treatment
highly
toxic,
leading
to
discontinuation
emergence
resistant
strains.
In
this
study,
we
assessed
leishmanicidal
activity
chemical
composition
red
propolis
collected
from
Amazon-dominated
region
northern
Tocantins
State,
Brazil.
The
MTT
assay
was
employed
determine
samples’
against
Leishmania
amazonensis
promastigotes
their
cytotoxicity
RAW
macrophages.
Spectrophotometric
assays
were
utilised
measure
concentrations
total
phenolics
flavonoids,
while
high-performance
liquid
chromatography
coupled
a
mass
spectrometer
(LC-MS/MS)
used
composition.
An
in
silico
study
conducted
evaluate
which
compounds
Brazilian
Amazon
may
correlate
with
biological
activity.
exhibited
high
concentration
phenolic
an
inhibitory
L.
amazonensis,
IC50
ranging
23.37
36.10
µg/mL.
Moreover,
fractionation
yielded
fraction
enhanced
bioactivity
(16.11
µg/mL).
Interestingly,
neither
nor
most
active
showed
towards
macrophages
at
up
200
colour
presence
isoflavonoid
components
(isoflavones,
isoflavans,
pterocarpans)
confirm
that
substance
propolis.
However,
absence
polyprenylated
benzophenones
suggests
new
variety
performed
two
main
drug
targets
using
all
identified
reported
liquiritigenin
compound
best
electronic
interaction
parameters,
confirmed
standard.
findings
indicate
possesses
activity,
low
toxicity,
significant
biotechnological
potential.