Endocrines,
Journal Year:
2024,
Volume and Issue:
5(4), P. 585 - 599
Published: Dec. 3, 2024
Background:
The
ketogenic
diet
(KD),
characterized
by
high-fat
content,
virtually
no
carbohydrates,
and
adequate
protein
intake,
induces
a
metabolic
state
resembling
fasting,
as
the
absence
of
carbohydrates
forces
body
to
rely
on
energetic
supply
from
hepatically
produced
ketone
bodies
using
free
fatty
acids
substrate.
While
KD
is
clinically
used
in
pharmacologically
refractory
epilepsy
specific
genetic
conditions
such
GLUT1
deficiency,
recent
research
suggests
that,
due
its
“fasting
mimicking”
properties,
may
also
beneficially
affect
obesity
obesity-associated
diseases.
Results:
Here,
we
present
narrative
review
discussing
completed
ongoing
nutritional
studies
human
volunteers
specifically
addressing
potential
an
anti-obesity
approach
and,
larger
perspective,
intervention
ameliorate
type
1
2
diabetes
polycystic
ovary
syndrome
(PCOS).
Published
well
clinical
trials
will
be
discussed.
Efficacy
safety
considerations
discussed,
physiological
mechanisms
mediating
effects
humans
context
(i)
energy
balance
model
(EBM)
(ii)
carbohydrate–insulin
(CIM)
weight
control.
Conclusion:
Ketogenic
diets
beneficial
attenuate
improve
obesity-related
disease,
here,
try,
based
current
evidence,
define
boundaries
KD’s
usefulness.
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 29, 2024
Abstract
Objective
This
study
aimed
to
investigate
the
effects
of
Chitosan/Alginate-loaded
Astragalus
hamosus
extract
(AH)
on
expression
miRNA-222
and
ESR1
genes,
pro-inflammatory
cytokines,
lipid
profiles,
sex
hormone
levels
in
rats
with
PCOS-induced
by
estradiol
valerate
(EV).
Methods
25
female
Wistar
rats,
an
average
weight
180
g,
were
divided
into
control
PCOS
groups.
The
model
was
induced
a
single
intramuscular
injection
EV
(4
mg/kg).
After
28
days
induction,
orally
administered
AH
at
doses
5,
10,
15
mg/kg.
Following
four
weeks
treatment,
histological
biochemical
parameters,
body
weight,
genes
evaluated.
Results
EV-induced
exhibited
significant
increase
abnormal
elevated
cytokine
levels,
altered
upregulation
expression,
downregulation
gene
expression.
administration
(Chn/Al-AH)
demonstrated
ameliorative
restoring
both
endocrine
metabolic
abnormalities
normal
attenuating
complications
rats.
Notably,
it
significantly
reduced
promoted
follicular
development
various
stages
while
reducing
cystic
follicles
increasing
corpus
luteum
formation.
Conclusions
Chn/Al-AH
found
have
beneficial
improving
certain
rat
models.
Quality in Sport,
Journal Year:
2024,
Volume and Issue:
19, P. 53209 - 53209
Published: July 28, 2024
Polycystic
ovary
syndrome
(PCOS)
is
an
endocrine
disorder
caused
by
multiple
genetic
and
environmental
factors,
affecting
women
of
reproductive
age
but
extending
across
all
stages
a
woman's
life
[1].
Major
symptoms
in
many
PCOS
patients
include
menstrual
cycle
irregularities,
difficulties
maintaining
normal
body
weight,
excessive
hair
growth,
acne,
fertility
problems.
The
prevalence
varies
depending
on
the
definition
used,
ranging
between
6-20%,
making
it
most
common
among
[2,3].
It
accounts
for
approximately
80%
cases
anovulatory
infertility,
disrupting
various
axis.
Evidence
from
numerous
studies
suggests
that
lifestyle
modification
should
be
first-line
therapy
with
[4].
This
paper
focuses
research
evaluating
treatment
this
condition
through
changes,
physical
activity,
diet.
Such
therapeutic
interventions
can
significantly
improve
clinical
outcomes
health
profile
promoting
favorable
changes
composition,
partially
normalizing
sex
hormone
levels,
reducing
inflammatory
parameters,
improving
mental
health.
Therefore,
adoption
comprehensive
modifications
crucial
polycystic
syndrome.
