Microbiome Integrity Enhances the Efficacy and Safety of Anticancer Drug
Biomedicines,
Journal Year:
2025,
Volume and Issue:
13(2), P. 422 - 422
Published: Feb. 10, 2025
The
intricate
relationship
between
anticancer
drugs
and
the
gut
microbiome
influences
cancer
treatment
outcomes.
This
review
paper
focuses
on
role
of
integrity
in
enhancing
efficacy
safety
drug
therapy,
emphasizing
pharmacokinetic
interactions
microbiota.
It
explores
how
disruptions
to
composition,
or
dysbiosis,
can
alter
metabolism,
immune
responses,
side
effects.
By
examining
mechanisms
disruption
caused
by
drugs,
this
highlights
specific
case
studies
like
cyclophosphamide,
5-fluorouracil,
irinotecan,
their
impact
microbial
diversity
clinical
also
discusses
microbiome-targeted
strategies,
including
prebiotics,
probiotics,
postbiotics,
fecal
microbiota
transplantation
(FMT),
as
promising
interventions
enhance
treatment.
Furthermore,
potential
profiling
personalizing
therapy
integrating
these
into
practice
is
explored.
Finally,
proposes
future
research
directions,
developing
novel
biomarkers
a
deeper
comprehension
drug-microbiome
interactions,
respond
current
gaps
knowledge
improve
patient
outcomes
care.
Language: Английский
Bacteriocins future perspectives: Substitutes to antibiotics
Athira Cheruvari,
No information about this author
Rajagopal Kammara
No information about this author
Food Control,
Journal Year:
2024,
Volume and Issue:
168, P. 110834 - 110834
Published: Aug. 27, 2024
Language: Английский
Lactobacillus plantarum Supplementation on Sport Performance, Biomarkers of Intestinal Damage, and Oxidative Stress in Recreational Athletes
Journal of Functional Morphology and Kinesiology,
Journal Year:
2025,
Volume and Issue:
10(2), P. 131 - 131
Published: April 15, 2025
Background:
In
recent
years,
interest
in
probiotic
supplementation
has
increased
among
athletes
due
to
its
potential
benefits
on
sports
performance.
Thus,
the
aim
of
this
trial
was
investigate
Lactobacillus
plantarum’s
effects
performance,
intestinal
damage,
and
oxidative
stress
biomarkers.
Methods:
Twenty-two
physically
active
participants,
nine
females
thirteen
males
(age:
32.8
±
5.2
years;
height:
1.73
0.1
m
(meters);
body
mass:
72.2
10.3
kg
(kilograms)
volunteered
randomized,
double-blind,
placebo-controlled,
parallel
study.
The
participants
performed
a
strenuous
exercise
session,
immediately
after,
their
perceived
exertion
assessed
blood
samples
were
drawn
assess
damage
(IFABP:
fatty
acid
binding
protein)
(PC:
protein
carbonyls;
TAC:
total
antioxidant
capacity;
proteins;
GSSG:
glutathione
disulfide;
GSH:
reduced
catalase).
Twenty-four
hours
later,
ranked
recovery
status
completed
various
performance
tests:
CMJ
(countermovement
jump),
RAST
(running-based
anaerobic
sprint),
YOYO
IR1
(YOYO
intermittent
test
level
1).
This
followed
by
four-week
period,
which
ingested
one
capsule
per
day
containing
10
billion
CFU
(colony
forming
units)
plantarum
or
placebo
(dextrose).
Results:
paired
t-test
revealed
significantly
better
result
group,
while
significant
reduction
observed
TAC
levels
group.
Conclusions:
results
suggest
that
could
increase
scores
may
mitigate
value
reduction.
Language: Английский
Microbiome-based precision nutrition: Prebiotics, probiotics and postbiotics
Adrián Odriozola,
No information about this author
Adriana González-Silvera,
No information about this author
Iñaki Odriozola
No information about this author
et al.
Advances in genetics,
Journal Year:
2024,
Volume and Issue:
unknown, P. 237 - 310
Published: Jan. 1, 2024
Language: Английский
The Improvement and Related Mechanism of Microecologics on the Sports Performance and Post-Exercise Recovery of Athletes: A Narrative Review
Keer Yang,
No information about this author
Yonglin Chen,
No information about this author
Minghan Wang
No information about this author
et al.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(11), P. 1602 - 1602
Published: May 24, 2024
The
diversity
and
functionality
of
gut
microbiota
may
play
a
crucial
role
in
the
function
human
motor-related
systems.
In
addition
to
traditional
nutritional
supplements,
there
is
growing
interest
microecologics
due
their
potential
enhance
sports
performance
facilitate
post-exercise
recovery
by
modulating
microecological
environment.
However,
lack
relevant
reviews
on
this
topic.
This
review
provides
comprehensive
overview
studies
investigating
effects
various
types
microecologics,
such
as
probiotics,
prebiotics,
synbiotics,
postbiotics,
enhancing
facilitating
regulating
energy
metabolism,
mitigating
oxidative-stress-induced
damage,
immune
responses,
attenuating
bone
loss.
Although
further
investigations
are
warranted
elucidate
underlying
mechanisms
through
which
exert
effects.
summary,
study
aims
provide
scientific
evidence
for
future
development
athletics.
Language: Английский
The interplay between gut microbiome and physical exercise in athletes
Current Opinion in Clinical Nutrition & Metabolic Care,
Journal Year:
2024,
Volume and Issue:
27(5), P. 428 - 433
Published: July 18, 2024
Purpose
of
review
The
gut
microbiome
regulates
several
health
and
disease-related
processes.
However,
the
potential
bidirectional
relationship
between
physical
exercise
remains
uncertain.
Here,
we
evidence
related
to
in
athletes.
Recent
findings
effect
on
intestinal
epithelial
cells
depends
type,
volume,
intensity
activity.
Strenuous
negatively
impacts
microbiome,
but
adequate
training
dietary
planning
could
mitigate
these
effects.
An
increase
short-chain
fatty
acids
(SCFAs)
concentrations
can
modulate
signaling
pathways
skeletal
muscle,
contributing
greater
metabolic
efficiency,
preserving
muscle
glycogen,
consequently
optimizing
performance
recovery.
Furthermore,
higher
SCFAs
appear
lower
inflammatory
response,
preventing
an
exacerbated
immune
response
reducing
risk
infections
among
Regarding
interventions,
optimal
diet
composition
for
targeting
athlete's
is
not
yet
known.
Likewise,
benefits
or
harms
using
probiotics,
synbiotics,
postbiotics
are
well
established,
whereas
prebiotics
optimize
production.
Summary
plays
important
role
modulating
health,
performance,
recovery
be
main
metabolite
Nutritional
strategies
focusing
need
developed
tested
controlled
clinical
trials.
Language: Английский
Mechanism of Action and Beneficial Effects of Probiotics in Amateur and Professional Athletes
Yousef Nami,
No information about this author
Anahita Barghi,
No information about this author
Mehdi Shahgolzari
No information about this author
et al.
Food Science & Nutrition,
Journal Year:
2024,
Volume and Issue:
13(1)
Published: Dec. 12, 2024
ABSTRACT
Probiotics
are
live
microorganisms
that,
when
administered
in
adequate
amounts,
provide
health
benefits
to
the
host.
According
International
Society
of
Sports
Nutrition
(ISSN),
probiotic
supplementation
can
optimize
health,
performance,
and
recovery
athletes
at
all
stages
their
careers.
Recent
research
suggests
that
probiotics
improve
immune
system
functions,
reduce
gastrointestinal
distress,
increase
gut
permeability
athletes.
Additionally,
may
with
secondary
could
positively
affect
athletic
performance
through
enhanced
from
fatigue,
improved
function,
maintenance
healthy
tract
function.
The
integration
some
strains
into
athletes'
diets
consumption
multi‐strain
compounds
lead
an
improvement
performance‐related
aspects
such
as
muscle
pain,
body
composition,
cardiorespiratory
fitness.
In
summary,
be
beneficial
for
careers,
amateur
professional.
This
paper
reviews
progress
on
role
improving
energy
metabolism
reducing
enhancing
fatigue
different
levels.
Language: Английский
Alleviating effect of Lactobacillus rhamnosus SDSP202418 on exercise-induced fatigue in mice
Yang Yang,
No information about this author
Yuanji Zhao,
No information about this author
Huan Lei
No information about this author
et al.
Frontiers in Microbiology,
Journal Year:
2024,
Volume and Issue:
15
Published: Sept. 26, 2024
In
this
study,
the
effects
of
Lactobacillus
rhamnosus
SDSP202418
isolated
from
shrimp
paste
on
exercise
performance
fatigued
mice
were
analyzed,
and
potential
action
mechanism
was
revealed.
L.
significantly
improved
exhaustion
time
regulated
biochemical
indices
(lactate
dehydrogenase,
nitrogen,
uric
acid)
to
resist
fatigue.
also
upregulated
mRNA
expression
slow
muscle
fibers
downregulated
fast
in
by
activating
AMPK/PGC-1α
pathway
mice.
It
increased
contents
antioxidant
enzymes
(superoxide
dismutase
(SOD),
catalase
(CAT),
glutathione
(GSH))
liver
muscle.
These
removed
repaired
oxidative
free
radicals
achieve
antifatigue.
addition,
can
change
gut
microbial
structure
modulate
abundance
balance
fatigue-related
microbiota,
which
turn
exerts
antifatigue
effects.
is
a
functional
food
component
that
relieves
fatigue
after
exercise.
Language: Английский
Microbiome of athletes: Its features and diversity: A literature review
International Journal of Medicine and Medical Research,
Journal Year:
2024,
Volume and Issue:
10(1), P. 56 - 63
Published: April 22, 2024
The
microbiome
of
athletes
is
the
greatest
interest
among
researchers,
as
microbial
composition
colon
plays
a
key
role
in
absorption
nutrients,
synthesis
vitamins,
and
immune
response
host
body.
purpose
this
review
was
to
investigate
relationship
between
gut
microbiota
high-performance
people
with
low-activity
lifestyles,
effect
these
changes
on
production
metabolites
that
are
associated
physical
performance
athletic
athletes.
A
total
42
research
papers
were
analysed,
including
11
specialised
studies
examined
intense
activity
different
types
19
focused
correlation
individual
bacteria
performance.
Gut
has
been
found
be
likely
improve
recovery.
Physical
shown
increase
α-diversity
metabolites,
such
short-chain
fatty
acids,
compared
who
have
lifestyle.
There
no
significant
differences
sports.
characterised
by
higher
amount
which
can
energy
substrates
during
exercise.
acids
Eubacterium
rectale,
Blautia
spp.,
Faecalibacterium
prausnitzii.
athletes’
also
demonstrated
presence
Prevotella
may
correlate
It
Veillonella
atypica
positively
correlates
endurance.
Despite
fact
findings
contradictory,
sports
achievements
health
specialising
various
Akkermansia
municiphila,
prausnitzii,
Roseburia
hominis.
In
addition,
it
there
link
enzymes
considered
Language: Английский
Fucoidan from Undaria pinnatifida Enhances Exercise Performance and Increases the Abundance of Beneficial Gut Bacteria in Mice
Marine Drugs,
Journal Year:
2024,
Volume and Issue:
22(11), P. 485 - 485
Published: Oct. 29, 2024
Fucoidans,
known
for
their
diverse
biological
properties
such
as
anti-inflammatory,
antiviral,
antitumor,
and
immune
stimulatory
effects,
have
recently
gained
attention
potential
benefits
in
exercise
endurance,
muscle
mass,
anti-fatigue.
However,
the
mechanisms
by
which
fucoidans
enhance
performance
are
still
unclear.
To
investigate
these
we
administered
400
mg/kg/day
of
fucoidan
extract
derived
from
Language: Английский