OBM Neurobiology,
Journal Year:
2024,
Volume and Issue:
08(04), P. 1 - 28
Published: Nov. 20, 2024
The
gut
microbiota,
a
complex
ecosystem
of
billions
microorganisms
in
the
human
digestive
tract,
plays
crucial
role
maintaining
health.
Recent
studies
have
highlighted
bidirectional
communication
pathway
called
gut-brain
axis
between
and
brain.
This
is
significantly
influenced
by
microbiota
its
interactions
with
immune
system,
which
can
affect
brain
function
contribute
to
inflammation.
study
aims
provide
comprehensive
overview
relationship
neuroinflammation,
focusing
on
underlying
mechanisms
implications
for
neurological
disorders.
A
thorough
literature
review
was
conducted,
examining
impact
this
interaction,
potential
therapeutic
applications.
modulates
neuroinflammation
through
various
pathways,
including
producing
short-chain
fatty
acids
(SCFAs),
modulating
regulating
nervous
system.
Dysbiosis,
characterized
an
imbalance
composition,
has
been
associated
increased
risk
conditions.
Interventions
such
as
probiotics,
prebiotics,
fecal
transplantation
show
promise
treating
neuroinflammation.
Understanding
pivotal
essential
developing
novel
strategies
prevent
manage
diseases.
Further
research
needed
elucidate
involved,
identify
specific
profiles
different
disorders,
optimize
personalized
therapies
based
microbiome
modulation.
Quality in Sport,
Journal Year:
2024,
Volume and Issue:
15, P. 52004 - 52004
Published: July 5, 2024
Introduction
Neurodegenerative
diseases,
such
as
Parkinson's
disease
(PD)
and
Alzheimer's
(AD),
pose
a
major
public
health
challenge
due
to
their
progressive
nature
profound
impact
on
patients
healthcare
systems.
Emerging
evidence
underscores
the
key
role
of
gut
microbiota
in
pathogenesis
progression
these
diseases.
This
paper
examines
current
state
knowledge
PD
AD,
focusing
mechanisms
modulation
inflammation,
blood-brain
barrier
integrity,
neurotransmitter
production
amyloid
pathology.
Future
research
should
target
potential
hidden
fully
exploit
therapeutic
neurodegenerative
Aim
study
review
aims
summarize
mainly
disease.
Materials
methods
The
PubMed
database
articles
from
last
10
years
were
reviewed.
Keywords
used
search
included
“gut
microbiota,”
“Parkinson’s
disease,”
“Alzheimer’s
“gut-brain
axis.”
Selected
studies
then
analyzed
obtain
information
action.
Conclusions
Intestinal
microflora
plays
significant
Modulating
it
through
dietary
interventions,
probiotics
prebiotics
holds
promise
for
new
strategies.
Research
gut-brain
axis
its
neurodegeneration
will
enable
creation
therapies.
Cureus,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 27, 2024
Parkinson's
disease
(PD)
is
a
progressive
neurodegenerative
disorder
with
complex
etiology.
Emerging
evidence
suggests
that
diet
may
play
role
in
PD
risk,
progression,
and
symptom
management.
However,
the
relationship
between
dietary
factors
remains
poorly
understood.
This
systematic
review
aimed
to
synthesize
evaluate
current
on
associations
patterns,
specific
nutrients,
We
conducted
comprehensive
literature
search
major
databases
for
studies
published
up
2024.
Eligible
included
prospective
cohorts,
case-control
studies,
randomized
controlled
trials,
cross-sectional
analyses
investigating
PD.
Data
extraction
quality
assessment
were
performed
independently
by
two
reviewers.
Eleven
met
inclusion
criteria.
Adherence
healthy
particularly
those
rich
fruits,
vegetables,
whole
grains,
fish,
was
consistently
associated
reduced
risk.
Conversely,
Western-style
diets
high
processed
foods
red
meat
linked
increased
Specific
including
antioxidants
vitamins
K
C,
showed
potential
neuroprotective
effects,
while
iron
intake
Diet
found
influence
symptoms,
non-motor
symptoms
like
constipation.
suggested
gut
microbiome
mediating
diet-PD
relationships.
Specialized
diets,
such
as
ketogenic
low-carbohydrate
promise
managing
small-scale
studies.
provides
significant
of
Dietary
interventions
have
serve
complementary
approaches
existing
therapies.
nature
necessitates
further
research,
well-designed
long-term
develop
evidence-based,
personalized
recommendations
prevention
OBM Neurobiology,
Journal Year:
2024,
Volume and Issue:
08(04), P. 1 - 28
Published: Nov. 20, 2024
The
gut
microbiota,
a
complex
ecosystem
of
billions
microorganisms
in
the
human
digestive
tract,
plays
crucial
role
maintaining
health.
Recent
studies
have
highlighted
bidirectional
communication
pathway
called
gut-brain
axis
between
and
brain.
This
is
significantly
influenced
by
microbiota
its
interactions
with
immune
system,
which
can
affect
brain
function
contribute
to
inflammation.
study
aims
provide
comprehensive
overview
relationship
neuroinflammation,
focusing
on
underlying
mechanisms
implications
for
neurological
disorders.
A
thorough
literature
review
was
conducted,
examining
impact
this
interaction,
potential
therapeutic
applications.
modulates
neuroinflammation
through
various
pathways,
including
producing
short-chain
fatty
acids
(SCFAs),
modulating
regulating
nervous
system.
Dysbiosis,
characterized
an
imbalance
composition,
has
been
associated
increased
risk
conditions.
Interventions
such
as
probiotics,
prebiotics,
fecal
transplantation
show
promise
treating
neuroinflammation.
Understanding
pivotal
essential
developing
novel
strategies
prevent
manage
diseases.
Further
research
needed
elucidate
involved,
identify
specific
profiles
different
disorders,
optimize
personalized
therapies
based
microbiome
modulation.
