Nutritional Intake and Lifestyle in Infertile Women with and without Polycystic Ovary Syndrome: A Case-control Study DOI Open Access
Sanaz Alaee, Maryam Ekramzadeh, Mohammad Samare‐Najaf

et al.

Journal of Infertility and Reproductive Biology, Journal Year: 2024, Volume and Issue: 12(4), P. 15 - 30

Published: Dec. 20, 2024

Background: Polycystic ovary syndrome (PCOS), the most common endocrine pathology in females of reproductive age worldwide, is a multifactorial disorder. Although obesity, lifestyle, depression, and nutrition are considered possible contributing factors to PCOS pathogenesis, association between nutrient intake, clinical indices, adipokines women not comprehensively elucidated. Therefore, current study aimed reveal contribution nutritional intake lifestyle pathogenesis disease. Methods: 90 infertile women, 45 with as cases without controls, aged 25–40 years were enrolled study. Different questionnaires including antioxidant food frequency (using Nut4 software), international physical activity, fast internet addiction completed by participants. Moreover, demographic characteristics, weight, height, BMI, serum levels hormones, blood glucose, malondialdehyde (MDA), chemerin, vaspin, omentin-1 measured. Results: No significant differences two groups obtained regarding (p-value>0.05). calories macronutrients did significantly differ However, androgens, AMH, LH, LH: FSH ratio, FBS, MDA higher estradiol was lower subjects compared controls (p-value<0.001). correlation parameters indicators observed (p-value<0.05). Conclusion: The findings may suggest that crucially contributes through hyperandrogenism weight gain.

Language: Английский

Introduction to Polycystic Ovary Syndrome (PCOS) and Nutritional Challenges DOI
Bancha Yingngam,

Chakkrapong Chaiburi,

Abhiruj Navabhatra

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Polycystic Ovary Syndrome: Etiopathogenic and Diagnostic Advances DOI Open Access

F. Elilie Mawa Ongoth,

Jostin Régis Gauthier Buambo,

Nestor Ghislain Andzouana Mbamognoua

et al.

Open Journal of Endocrine and Metabolic Diseases, Journal Year: 2025, Volume and Issue: 15(04), P. 45 - 59

Published: Jan. 1, 2025

Language: Английский

Citations

0
Metformin in gynecological disorders: pathogenic insights and therapeutic implications DOI Creative Commons
Ping Nie, Minghua Wang, Yan Mo

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 22, 2025

Metformin, the most widely used anti-diabetic drug, has been demonstrated to exert various effects, including antioxidant, anti-inflammatory, anti-tumor, and cardioprotective properties. Due its affordability low toxicity profile, metformin is increasingly prevent or treat a wide range of gynecological disorders, as evidenced by epidemiological studies, clinical trials, animal in vitro studies. Trial findings for non-cancer conditions such endometriosis, premature ovarian failure (POF), uterine fibroids remain controversial insufficient. However, current trials polycystic syndrome (PCOS) malignancies are ongoing phase II-III trials. The pharmacological effects have shown target insulin-like growth factor (IGF), AMP-activated protein kinase (AMPK), phosphatidylinositol 3-kinase (PI3K)/AKT, MAPK, NF-κB, other signal transduction pathways, highlighting potential treatment disorders. In this review, we discuss biological impacts mechanisms action pertinent different

Language: Английский

Citations

0
Association between neutrophil percentage-to-albumin ratio and breast cancer in adult women in the US: findings from the NHANES DOI Creative Commons

Huikai Liang,

Kelun Pan,

Jiayi Wang

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: April 28, 2025

An increasing number of studies suggests an association between systemic inflammation, nutritional status, and cancer. However, the relationship prevalence breast cancer (BC) neutrophil-percentage-to-albumin ratio (NPAR), a recently identified biomarker is not well established. Therefore, this study aims to investigate BC risk NPAR. This included 18,726 participants from National Health Nutrition Examination Survey (NHANES) conducted 2001 2018. The NPAR was used assess inflammation status. Statistical methods such as multivariate logistic regression, subgroup analysis, restricted cubic spline (RCS) analysis were influence on BC. In addition, propensity score matching employed further validate findings. regression results showed that significantly associated with (OR = 1.05; 95% CI 1.02-1.09, p 0.003). comparison in lowest quartile, Q1, increased by 5% for those Q2 (p 0.745), 3% Q3 0.032), 38% Q4 0.018) higher RCS analyses positively correlated. Furthermore, significant observed marital significance traits assessed using mean decrease accuracy (MDA) impurity (MDI). These measures random forest modeling one major factors affecting linear demonstrated correlation high total testosterone sex hormone-binding globulin (SHBG) levels. A cancer, which could be attributable hormone finding may serve adult women US.

Language: Английский

Citations

0
Genetic–epigenetic targets for PCOS-associated diabesity DOI
Arun Kumar Sharma,

Monalisa Mukherjee,

Md Sayeed Akhtar

et al.

Drug Discovery Today, Journal Year: 2025, Volume and Issue: unknown, P. 104373 - 104373

Published: May 1, 2025

Language: Английский

Citations

0
The Relationship Between Obesity, Bariatric Surgery, and Infertility: A Systematic Review DOI Creative Commons
Charalampos Voros, Antonia Varthaliti,

Kyriakos Bananis

et al.

Life, Journal Year: 2025, Volume and Issue: 15(5), P. 758 - 758

Published: May 9, 2025

Background: Obesity is a complicated, chronic condition that has major impact on reproductive health, leading to infertility, anovulation, and poor pregnancy outcomes. It alters the hypothalamic–pituitary–ovarian (HPO) axis, promotes insulin resistance, causes persistent low-grade inflammation, all of which result in hormonal abnormalities compromise normal ovarian function. Because standard weight loss procedures frequently fail provide significant long-term benefits, bariatric surgery becoming increasingly popular as therapeutic option for obese women trying conceive. However, continuous research being conducted determine degree its advantages potential hazards fertility Methods: This systematic review was accordance with Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA) standards entered into PROSPERO database. Comprehensive searches PubMed, Scopus, Web Science databases turned up relevant studies. Studies examined effects female fertility, ovulatory function, rates, neonatal outcomes were considered. Methodological quality risk bias evaluated using Newcastle–Ottawa Scale (NOS) observational studies Cochrane Risk Bias Tool randomized controlled trials. Results: comprised 34 More than 75% analyzed showed improvements monthly regularity, or spontaneous after surgery. Post-surgical pregnancies are related lower incidence gestational diabetes, hypertension, macrosomia. several raised concerns about nutritional inadequacies possibility small-for-gestational-age newborns, particularly following Roux-en-Y gastric bypass. suggest delaying conception 12 18 months reduce improve Variability study design, follow-up duration, surgical methods reduces generalizability findings, emphasizing importance uniform protocols. Conclusions: Bariatric highly effective treatment increasing women, those PCOS. rigorous preconception planning, postoperative monitoring, multidisciplinary required hazards. Future should concentrate outcomes, standardizing assessment criteria, improving clinical guidelines managing post-bariatric pregnancies. These findings support incorporation regimens they may shape future revisions care

Language: Английский

Citations

0
Higher body roundness index (BRI) increases infertility among U.S. women aged 18–45 years DOI Creative Commons

Hongyang Gong,

Shuqin Duan,

Seok Choi

et al.

BMC Endocrine Disorders, Journal Year: 2024, Volume and Issue: 24(1)

Published: Dec. 18, 2024

Abstract Objective Infertility is associated with obesity. The Body Roundness Index (BRI) a body measurement index related to obesity that more accurately assesses and visceral fat levels. However, the relationship between BRI infertility remains unclear. Therefore, this study aims determine infertility. Methods This utilized data from National Health Nutrition Examination Survey (NHANES) 2013 2018 included 3,528 women aged 18–45 years. Multivariate logistic regression was employed investigate association Restricted cubic spline (RCS) analysis explored linear or non-linear Interaction analyses were conducted on subgroups validate findings. To verify robustness of results, we performed several sensitivity analyses, including propensity score matching(PSM) multiple imputations for missing data. Furthermore, predictive capabilities various anthropometric indices—including BRI, weight-adjusted waist (WWI), mass (BMI), weight—on incidence assessed using Receiver Operating Characteristic (ROC) curve analysis. Results There significant positive After adjusting covariates, each unit increase in there 12% probability ( P < 0.001). correlation persisted when categorized into quartiles. Moreover, as increased, trend towards higher prevalence dose-response indicated infertility, risk. subgroup imputations. ROC revealed had superior capability compared traditional indices, an area under (AUC) 0.618 (95% CI, 0.588–0.648). Conclusion results show strong Clinical trial number Not Applicable.

Language: Английский

Citations

1
Association between Coffee Consumption and Polycystic Ovary Syndrome: An Exploratory Case–Control Study DOI Open Access

Aïcha Meliani-Rodríguez,

Ana Cutillas-Tolín, Jaime Mendiola

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(14), P. 2238 - 2238

Published: July 11, 2024

Polycystic ovary syndrome (PCOS) is a leading cause of infertility, with an estimated worldwide prevalence between 5% and 15%. We conducted case-control study 121 PCOS patients 155 controls to assess the association coffee intake presence having diagnosis in women Murcia, Spain. The was determined following Rotterdam criteria (the two three conditions: hyperandrogenism, oligo-anovulation, and/or polycystic ovarian morphology). Coffee consumption assessed using validated food frequency questionnaire. Adjusted odds ratios (ORs) 95% confidence intervals (CIs) were multiple logistic regression. categorized into never, less than one cup per day, or more cups day. found significant inverse linear trend: higher consumption, lower probability multivariable analysis (

Language: Английский

Citations

1
Impact of short‐term ketogenic diet on sex hormones and glucose‐lipid metabolism in overweight or obese patients with polycystic ovary syndrome DOI Open Access

Meng Li,

Lisong Zhang, Xiaoyu Li

et al.

Journal of Obstetrics and Gynaecology Research, Journal Year: 2024, Volume and Issue: 51(1)

Published: Dec. 11, 2024

This study evaluates the clinical effects of a ketogenic diet (KD) versus traditional comprehensive intervention, including lifestyle changes and oral contraceptives, in overweight or obese polycystic ovary syndrome (PCOS) patients.

Language: Английский

Citations

1
Association between visceral adipose surrogates and infertility among reproductive-aged females: a cross-sectional study DOI Creative Commons

Dongli Guo,

Renxi Wang

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 12, 2024

Background Visceral adipose tissue (VAT) exerts a substantial influence on female infertility. Nevertheless, the relationship between VAT surrogates and infertility remains ambiguous. Methods This study employed cross-sectional design analyzed data from National Health Nutrition Examination Survey (NHANES, 2012–2016). Weighted logistic regression models were utilized to examine association Furthermore, Receiver Operating Characteristic (ROC) curve analysis was conducted assess diagnostic efficacy of these for Results Individuals experiencing exhibited markedly elevated levels Chinese Adiposity Index (CVAI) (108.30 vs. 69.86, P &lt;0.001) (VAI) (1.68 1.35, &lt;0.001). When considered as continuous variable, CVAI (odds ratio [OR]: 1.06, 95% confidence interval [CI]: 1.03-1.09, &lt;0.001), rather than VAI (OR:1.02, 95%CI: 0.98-1.06, =0.259), demonstrated significant with risk Consistent findings also evident after dividing participants into 4 subgroups based quartiles. Additionally, ROC curves indicated that most robust value compared other indices. Subgroup analyses revealed across different populations. Conclusion Females faced significantly heightened in United States. holds promise valuable tool stratifying

Language: Английский

Citations

1