Journal of Infertility and Reproductive Biology,
Journal Year:
2024,
Volume and Issue:
12(4), P. 15 - 30
Published: Dec. 20, 2024
Background:
Polycystic
ovary
syndrome
(PCOS),
the
most
common
endocrine
pathology
in
females
of
reproductive
age
worldwide,
is
a
multifactorial
disorder.
Although
obesity,
lifestyle,
depression,
and
nutrition
are
considered
possible
contributing
factors
to
PCOS
pathogenesis,
association
between
nutrient
intake,
clinical
indices,
adipokines
women
not
comprehensively
elucidated.
Therefore,
current
study
aimed
reveal
contribution
nutritional
intake
lifestyle
pathogenesis
disease.
Methods:
90
infertile
women,
45
with
as
cases
without
controls,
aged
25–40
years
were
enrolled
study.
Different
questionnaires
including
antioxidant
food
frequency
(using
Nut4
software),
international
physical
activity,
fast
internet
addiction
completed
by
participants.
Moreover,
demographic
characteristics,
weight,
height,
BMI,
serum
levels
hormones,
blood
glucose,
malondialdehyde
(MDA),
chemerin,
vaspin,
omentin-1
measured.
Results:
No
significant
differences
two
groups
obtained
regarding
(p-value>0.05).
calories
macronutrients
did
significantly
differ
However,
androgens,
AMH,
LH,
LH:
FSH
ratio,
FBS,
MDA
higher
estradiol
was
lower
subjects
compared
controls
(p-value<0.001).
correlation
parameters
indicators
observed
(p-value<0.05).
Conclusion:
The
findings
may
suggest
that
crucially
contributes
through
hyperandrogenism
weight
gain.
Frontiers in Endocrinology,
Journal Year:
2024,
Volume and Issue:
15
Published: Sept. 9, 2024
Background
Polycystic
ovary
syndrome
(PCOS)
is
defined
by
oligo/anovulation,
hyperandrogenism,
and
polycystic
ovaries
with
uncertain
pathogenesis.
The
proteome
represents
a
substantial
source
of
therapeutic
targets,
their
coding
genes
may
elucidate
the
mechanisms
underlying
PCOS.
However,
reports
on
profiles
human
plasma
protein-coding
PCOS
are
limited.
Here,
we
aimed
to
investigate
novel
biomarkers
or
drug
targets
for
integrating
genetics
proteome.
Methods
Our
study
acquired
protein
quantitative
trait
loci
from
DECODE
Genetics,
offering
4,907
proteins
in
35,559
individuals
while
obtaining
summary
statistics
accessing
FinnGen
biobank
(1,639
cases
218,970
controls)
genome-wide
association
catalog
(797
140,558
controls).
Herein,
sequentially
used
two-sample
Mendelian
randomization
(MR)
analyses
colocalization
verify
causal
link
between
candidate
proteins,
genes,
Further
data
download
was
conducted
Gene
Expression
Omnibus
Zenodo
platforms.
expression
level
analysis,
pathway
enrichment
immune
cell
infiltration,
transcription
factor
prediction
were
performed,
aiming
at
detecting
specific
types
enriched
exploring
potential
optimized
treatments
Results
MR
analysis
revealed
243
relationship
risk,
which
12
prioritized
most
significant
evidence.
Through
three
key
CUB
domain-containing
1
(
CDCP1
),
glutaredoxin
2
GLRX2
kirre-like
nephrin
family
adhesion
molecule
KIRREL2
identified.
Subsequently,
strongly
related
function
metabolism
terms
biological
significance.
In
single-cell
levels
ovarian
theca
cells
explored.
Conclusion
Overall,
,
)
be
higher
suggesting
that
they
entry
points
exploration
pathogenesis
treatment,
warranting
further
clinical
investigations.
ACS Omega,
Journal Year:
2024,
Volume and Issue:
9(50), P. 49054 - 49063
Published: Dec. 3, 2024
Aims:
To
investigate
the
diagnostic
value
of
oviduct
glycoprotein
1
(OVGP1)
levels
for
polycystic
ovary
syndrome
(PCOS).
Materials
and
Methods:
Serum
OVGP1
concentrations
were
measured
by
enzyme-linked
immunosorbent
assay
(ELISA).
Associations
between
endocrine
parameters
evaluated
Spearman's
correlation
analysis.
Diagnostic
capacity
was
assessed
utilizing
machine
learning
algorithms
receiver
operating
characteristic
(ROC)
curves.
Results:
significantly
decreased
in
PCOS
patients
correlated
with
serum
follicle-stimulating
hormone
(FSH)
concentration
luteinizing
hormone/follicle-stimulating
(LH/FSH)
ratio,
which
are
predictors
occurrence.
The
combined
six
signatures
(LH/FSH,
progesterone,
total
cholesterol,
triglyceride,
high-density
lipoprotein
anti-Müllerian
hormone)
or
three
clinical
indicators
has
potential
to
improve
accuracy
diagnosing
patients.
Conclusion:
enhances
ability
diagnose
when
indicators.
Journal of Infertility and Reproductive Biology,
Journal Year:
2024,
Volume and Issue:
12(4), P. 15 - 30
Published: Dec. 20, 2024
Background:
Polycystic
ovary
syndrome
(PCOS),
the
most
common
endocrine
pathology
in
females
of
reproductive
age
worldwide,
is
a
multifactorial
disorder.
Although
obesity,
lifestyle,
depression,
and
nutrition
are
considered
possible
contributing
factors
to
PCOS
pathogenesis,
association
between
nutrient
intake,
clinical
indices,
adipokines
women
not
comprehensively
elucidated.
Therefore,
current
study
aimed
reveal
contribution
nutritional
intake
lifestyle
pathogenesis
disease.
Methods:
90
infertile
women,
45
with
as
cases
without
controls,
aged
25–40
years
were
enrolled
study.
Different
questionnaires
including
antioxidant
food
frequency
(using
Nut4
software),
international
physical
activity,
fast
internet
addiction
completed
by
participants.
Moreover,
demographic
characteristics,
weight,
height,
BMI,
serum
levels
hormones,
blood
glucose,
malondialdehyde
(MDA),
chemerin,
vaspin,
omentin-1
measured.
Results:
No
significant
differences
two
groups
obtained
regarding
(p-value>0.05).
calories
macronutrients
did
significantly
differ
However,
androgens,
AMH,
LH,
LH:
FSH
ratio,
FBS,
MDA
higher
estradiol
was
lower
subjects
compared
controls
(p-value<0.001).
correlation
parameters
indicators
observed
(p-value<0.05).
Conclusion:
The
findings
may
suggest
that
crucially
contributes
through
hyperandrogenism
weight
gain.
