Short- and long-term impact by vasomotor symptoms in menopause and modern approaches to their correction DOI Creative Commons

V.G. Sіusіuka,

M.Y. Sergienko,

Mykhailo Pavliuchenko

et al.

Reproductive health of woman, Journal Year: 2024, Volume and Issue: 4, P. 63 - 69

Published: May 31, 2024

The importance of management in women menopause and postmenopause is not diminishing, but only gaining relevance. It estimated that by 2050, more than 1.6 billion worldwide will reach this age, compared to 1 2020. Vasomotor symptoms (VMS) are the most common affect 70% women. They diagnosed 35-50% perimenopause 30-80% postmenopause. Most these persist less 7 years after last menstrual period, one four may experience them up 10 years, ten years. based on complex endocrine, neuroendocrine epigenetic mechanisms. This article a review scientific literature publications aimed at determining impact VMSs women’s future life analysis published modern studies.VMSs have negative woman’s quality life, also potential for cardiovascular health. increased risk diseases (CVD) attributed sharp decrease endogenous estrogen levels, which indicates its cardioprotective effect premenopausal has been established factor coronary heart disease diabetes mellitus. presence non-alcoholic fatty liver significantly associated with an early severe forms among perimenopausal women.Taking into account spend third their lives postmenopausal it important analyze during difficult period. focusing healthy lifestyle as part primary prevention, including regular physical activity, calcium/vitamin D intake, maintaining optimal body weight, avoiding stress, etc. Menopausal hormone therapy (MHT) considered first-line treatment perimenopause. Its use should be individualized, initiation discontinuation age. Assessment baseline CVD risk, age period since important. priority before or under 60 who no contraindications MHT. Hormone indicated prevention CVD. However, improve profile due beneficial effects vascular function, lipid glucose metabolism, reduction mellitus.Non-hormonal VMS sufficient when there medical hormonal personal choice. MHT remains effective treatment.

Language: Английский

Impact of Estrogen on Purinergic Signaling in Microvascular Disease DOI Open Access
Jessica Cassavaugh, Maria Serena Longhi, Simon C. Robson

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2105 - 2105

Published: Feb. 27, 2025

Microvascular ischemia, especially in the heart and kidneys, is associated with inflammation metabolic perturbation, resulting cellular dysfunction end-organ failure. Heightened production of adenosine from extracellular nucleotides released response to results protective effects, inclusive adaptations hypoxia, endothelial cell nitric oxide release regulation vascular tone, inhibition platelet aggregation. Purinergic signaling modulated by ectonucleoside triphosphate diphosphohydrolase-1 (NTPDase1)/CD39, which dominant factor dictating metabolism ATP throughout cardiovascular tissues. Excess levels purine metabolites, however, have been diseases. Physiological estrogen anti-inflammatory but pharmacological replacement use transgender postmenopausal individuals thrombosis other side effects. Crucially, loss this important sex hormone following menopause or gender reassignment worsened pro-inflammatory states linked increased oxidative stress, myocardial fibrosis, and, ultimately, diastolic dysfunction, also known as Yentl syndrome. While there a growing body knowledge on distinctive purinergic health, much less about relationships between two pathways. Continued studies interactions these pathways will allow further insight into future therapeutic targets improve health aging women without imparting deleterious

Language: Английский

Citations

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Healthy adipose tissue after menopause: contribution of balanced diet and physical exercise DOI Creative Commons
Bruno Vecchiatto, Thiago Lucas de Castro,

Natália Juliana Ramos Ferreira

et al.

Published: March 14, 2025

The accumulation of adipose tissue is associated with metabolic disorders, including insulin resistance, type 2 diabetes (T2D), dyslipidemia, syndrome, and cardiovascular diseases (CVD). Menopause might predispose women to increase body weight tissue, decrease lean muscle mass. Furthermore, postmenopausal display fat mass redistribution greater in the visceral area mainly due hormonal shifts that result a higher testosterone/estradiol ratio. These effects are less favorable adipokine profile, cardiac dysfunction after menopause. Fat determined by balance between storage triacylglycerol (TAG) (lipogenesis) removal stored TAG (lipolysis) combination differentiation new adipocytes (adipogenesis). Disturbances dynamics lead an lipogenesis (hypertrophy) and/or adipogenesis (hyperplasia) accommodate excess energy intake. While large dysfunctional have secretion inflammatory adipocytokines, small healthier improvements. Different strategies can be used prevent or reduce gain mass, as well maintain healthy tissue; however, robust evidence, lifestyle interventions should pillars this process. This review provides comprehensive summary findings on role balanced diet physical exercise improving composition promoting women.

Language: Английский

Citations

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Disordered eating and body dissatisfaction in women with non-natural menopause DOI Creative Commons
Barbara Mangweth‐Matzek, Timo Schurr,

Sophia Vedova

et al.

Archives of Gynecology and Obstetrics, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

Language: Английский

Citations

0
Maternal Obesity and Adverse Pregnancy Outcomes as Mediators of Cardiovascular Disease Risk in Midlife DOI
Garima Sharma, Tiffany M. Powell‐Wiley,

Tiffany Brazile

et al.

Journal of the American College of Cardiology, Journal Year: 2025, Volume and Issue: 85(15), P. 1547 - 1549

Published: April 1, 2025

Language: Английский

Citations

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Chain effect of lifecourse reproductive characteristics and body fat and muscle on cardiovascular disease in women: a Mendelian randomization study DOI Creative Commons
Dong Liu, Chun Dou,

Chaojie Ye

et al.

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: April 18, 2025

Delineating the causal chain effects of reproductive traits and fat- muscle-related on cardiovascular disease (CVD) is essential for optimizing precision prevention control health in women. In this study, we applied two-sample Mendelian randomization (MR) analyses two-step MR framework to investigate mediating effect pathways among factors CVD outcomes women, applying genome-wide association study summary statistics 16 women's across puberty pre-pregnancy, pregnancy postpartum, menopausal transition stages, traits, five coronary artery (CAD), myocardial infarction (MI), heart failure, atrial fibrillation, ischemic stroke (IS) from over one million individuals European descent. The revealed associations genetically predicted nine (i.e., age at menarche [odds ratio (OR) CAD: 0.92], first sexual intercourse [AFS; 0.71], birth [AFB; 0.89], hypertensive disorders [HDP; 1.21], pre-eclampsia [PE; 1.34], preterm [PTB; 1.09], sex hormone-binding globulin [SHBG; 0.73], bioavailable testosterone [BT; 1.17], number stillbirths [OR IS: 2.14]) 13 with least outcomes. Two-step identified 30 where AFS, AFB, HDP, PE, PTB, SHBG, BT mediated body composition outcomes, waist-to-hip ratio, trunk-trunk fat abdominal subcutaneous adipose tissue, gluteofemoral tissue CAD MI. Lifecourse characteristics manifested reciprocal CVD, informing targeted strategies bridging inequalities

Language: Английский

Citations

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Nutrition and Neuroinflammation: Are Middle-Aged Women in the Red Zone? DOI Open Access

Veronique Bernier,

Angéline Chatelan,

Camille Point

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(10), P. 1607 - 1607

Published: May 8, 2025

Women exhibit unique vulnerabilities in health, especially regarding mental health and neurodegenerative diseases. Biological, hormonal, metabolic differences contribute to sex-specific risks that remain underrepresented clinical studies. Diseases such as major depressive disorder (MDD) Alzheimer’s disease (AD) are more prevalent women may be influenced by hormonal transitions, particularly during menopause. Chronic low-grade inflammation is emerging a shared mechanism underlying both conditions, this inflammatory state can worsened dietary habits. During menopause, mood sleep disturbances influence behavior, leading enhanced snacking consumption of high-glycemic comfort foods. Such foods, low nutritional value, promote weight gain elevated markers. Their combined (or not) with preexisting Western diet pattern—already linked inflammation—could reinforce systemic involving the gut–brain axis. Moreover, symptoms “per se” could act on well. Peripheral cross blood–brain barrier, sustaining disorders promoting changes. Finally, MDD AD associated conditions obesity diabetes, which occur frequently women. The review highlights how menopause-related changes mood, sleep, heighten susceptibility

Language: Английский

Citations

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Impact of aging on maximal oxygen uptake in female runners and sedentary controls DOI Creative Commons
Vinícius Ribeiro dos Anjos Souza, Lavínia Vivan, Aldo Seffrin

et al.

Experimental Gerontology, Journal Year: 2024, Volume and Issue: 193, P. 112476 - 112476

Published: June 3, 2024

The present study aimed to compare V̇O

Language: Английский

Citations

1
The Clínica Universidad de Navarra-Body Adiposity Estimator index is a reliable tool for screening metabolic dysfunction-associated steatotic liver disease: an analysis from a gender perspective DOI Creative Commons
Chao Wang, Xin Huang,

Shiming He

et al.

Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: Sept. 27, 2024

Language: Английский

Citations

1
The effects of cold exposure on body composition: Analysis with Computerized Bioimpedance DOI Open Access
Rodrigo Álvaro Brandão Lopes‐Martins,

Ludymilla Vicente Barbosa,

Mirian Martins Barbosa Souza

et al.

Manual Therapy Posturology & Rehabilitation Journal, Journal Year: 2024, Volume and Issue: 22

Published: Aug. 19, 2024

Introduction: Weight gain and obesity are common concerns for midlife women. Obesity is characterized by an accumulation of body fat resulting in weight at least 20% above the optimum. Objective: To evaluate efficacy cryolipolysis on composition Methods: Thirty women aged 30-55 with overweight underwent three sessions, (45 minutes each), spaced 15 days apart. Body was assessed using bioelectrical impedance before after intervention. Parameters measured included mass, lean muscle muscle/fat ratio, total water (TBW) percentage. Results: Significant reductions were observed both absolute mass (from 26 ± 1.5 kg to 24.4 1.51 kg, p<0.05) percentage 34.4 1.2% 32.8 1%, p<0.05). Lean remained stable (48.91 1.56 48.82 1.4 kg), a significant increase (65 67 1.2%, Muscle rise from 29 0.6% 31 0.7% (p<0.05). The ratio improved significantly 0.85 0.04 0.95 0.2 (p<0.05), TBW increased 46.5 0.9% 48 (p<0.01). Conclusion: Cryolipolysis enhances reducing maintaining improving hydration status. These findings underscore as effective non-invasive alternative contouring potential health benefits, including metabolic cardiovascular health. Future research should explore long-term effects mechanisms optimize clinical applications.

Language: Английский

Citations

0
Association between normal weight obesity and lipids profile in Slovak women aged 38 to 59 years DOI Creative Commons

Daniela Ferjančeková,

Petra Švábová, Alexandra Hozáková

et al.

Anthropological Review, Journal Year: 2024, Volume and Issue: 87(2), P. 99 - 111

Published: June 28, 2024

Obesity and its associated health problems are an issue, especially when weight gain is not outwardly visible. Individuals with the same Body Mass Index (BMI) may differ in body fat percentage unknowingly suffer from normal obesity (NWO). Middle-aged women at high risk if their composition changes due to factors such as age, status or reproductive history. This study investigated relationship between NWO lipid profile middle-aged women. A sample of 122 aged 38 59 years (47.17 ± 5.24) Slovakia participated this study. Using a questionnaire, participants answered questions about lifestyle, background, sociodemographic classification, menstrual The anthropometric parameters were determined using standard methods. was measured bioelectrical impedance analyzer. Biochemical morning blood samples. Blood pressure assessed sitting position digital sphygmomanometer. primary aim assess differences profiles NOW weight-lean (NWL) Our results showed statistically significantly higher values uric acid compared NWL (237.39 54.11 μmol/l vs. 213.02 52.64 μmol/l; p = 0.009). Moreover, significant noted height, weight, waist hip circumference, WHR, BMI mass (%, < 0.05). Other biochemical variables no groups Elevated levels diagnosed serve indication metabolic imbalance undetected obesity. These underscore importance implementing early detection intervention methods for prevent related issues. Further research necessary investigate underlying contributing these connections evaluate efficacy customized interventions.

Language: Английский

Citations

0