Centrality-Based Approach for Identifying Essential Cancer Proteins in PPI Networks DOI
Trilochan Rout,

Anjali Mohapatra,

Madhabananda Kar

et al.

SN Computer Science, Journal Year: 2024, Volume and Issue: 6(1)

Published: Dec. 16, 2024

Language: Английский

Dose-Weighted Network Pharmacology: Evaluating Traditional Chinese Medicine Formulations for Lumbar Disc Herniation DOI Creative Commons
C. Zhou, Ting Xiang, Yu Yu

et al.

Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 1281 - 1300

Published: Jan. 1, 2025

Lumbar disc herniation (LDH) significantly impacts individuals, particularly those aged 40-45. Traditional Chinese Medicine (TCM) formulations such as Taohong Siwu Decoction (TSD), Yaotong Jizheng (YJD), and Panlong Qi Tablet (PQT) are widely used for treatment. This study introduces dose-weighted network pharmacology, a novel approach that incorporates drug dosage quantitative factor into analysis to evaluate better compare the therapeutic potential of TCM formulations. combines with PPI propose theoretical algorithm comparing efficacy different traditional medicine The VIKOR method was assess importance targets, weights assigned based on both disease perspectives. TSD, YJD, PQT were evaluated in animal experiments, algorithm's feasibility validated through GO KEGG pathway analysis, Thermal Hyperalgesia Test, H&E staining, Western blotting (WB), RT-PCR, ELISA assays. computational model indicated YJD had higher predicted compared TSD. These predictions confirmed studies, where demonstrated greatest reduction thermal hyperalgesia most significant decrease inflammatory markers, surpassing TSD PQT. analyses highlighted key pathways related oxidative stress inflammation, providing mechanistic insights effectiveness treatments. Incorporating reference pharmacology research proved feasible effective, emphasizing precise control treating LDH. new provided reliable predictions, demonstrating its enhance design evaluation Future improvements, establishing target acceptance rate database, could further refine algorithm, expanding application personalized targeted therapy.

Language: Английский

Citations

0
Construction and Application of Protein-Protein Interaction Knowledge Graph DOI
Jing Xiong, Xiaohong Wang,

Fangkun Dou

et al.

Communications in computer and information science, Journal Year: 2025, Volume and Issue: unknown, P. 44 - 53

Published: Jan. 1, 2025

Language: Английский

Citations

0
Essential proteins in cancer networks: a graph-based perspective using Dijkstra’s algorithm DOI
Trilochan Rout,

Anjali Mohapatra,

Madhabananda Kar

et al.

Network Modeling Analysis in Health Informatics and Bioinformatics, Journal Year: 2024, Volume and Issue: 13(1)

Published: Aug. 19, 2024

Language: Английский

Citations

1
Essential Protein Identification in Cancer: A Graph-Based Approach Integrating Topological and Biological Features in PPI Networks DOI
Trilochan Rout,

Anjali Mohapatra,

Madhabananda Kar

et al.

SN Computer Science, Journal Year: 2024, Volume and Issue: 5(7)

Published: Oct. 9, 2024

Language: Английский

Citations

0
Centrality-Based Approach for Identifying Essential Cancer Proteins in PPI Networks DOI
Trilochan Rout,

Anjali Mohapatra,

Madhabananda Kar

et al.

SN Computer Science, Journal Year: 2024, Volume and Issue: 6(1)

Published: Dec. 16, 2024

Language: Английский

Citations

0