BMC Chemistry,
Journal Year:
2024,
Volume and Issue:
18(1)
Published: June 26, 2024
Abstract
Mathematical
manipulation
technique
has
proven
to
be
a
very
powerful
tool
for
efficient
processing
and
handling
of
highly
overlapped
spectra.
This
work
introduced
two
green
sustainable
approaches
the
successful
recovery
ternary
mixture,
Tylosin
tartarate
(TYL),
Sulfadimdine
(SLD),
Trimethoprim
(TRI).
The
were
constructed
using
three
different
methods,
derivative
ratio
spectrum
zero-crossing
method
(DRSZ),
double
divisor
spectra
(DDRD),
factorized
coupled
with
subtraction
(FDRM-SS).
succeeded
in
recovering
drugs
(Linearity
range
achieved
0.5–5
µg/mL
TYL,
0.3–1.3
SLD,
0.3–5
TRI),
giving
convenient
standard
deviations
satisfactory
percentages.
recommended
methods
have
been
verified
accordance
(ICH)
guidelines.
When
results
statistically
compared
official
no
significant
difference
was
found.
Both
AGREE—Analytical
GREEnness
Metric
Approach
Software,
White
Analytical
Chemistry
(WAC)
RGB
model
gave
scores
0.93
97.2%,
respectively,
which
proved
that
eco-friendly
abiding
by
sustainability
principles.
Microchemical Journal,
Journal Year:
2024,
Volume and Issue:
205, P. 111291 - 111291
Published: Aug. 5, 2024
Natural
deep
eutectic
solvents
(NADESs)
are
a
sustainable
and
green
solution
for
the
recovery
of
food
ingredients
such
as
pigments.
In
this
work,
extraction
conditions
to
obtain
maximum
anthocyanins
from
blackberry
fruit
were
investigated
using
NADES
composed
choline
chloride-acetic
acid
(CHAC)
solvent.
The
central
composite
design
was
used
conseidering
molar
ratio,
water
content,
solvent
ratio
time
independent
variables
total
anthocyanin
content
(TAC),
cyanidin-3-glucoside,
cyanidin-3-rutinoside,
pelargonidin-3-glucoside
cyanidin
chloride
responses.
results
showed
that
significantly
affected
optimum
CHAC
1:3.5
M,
40
%,
30
g
15
min
time,
respectively.
Under
these
conditions,
experimental
responses
131.54
±
7.89
mg
CGE/100
g,
1208.08
13.76
mg/kg,
163.43
1.72
53.78
1.37
mg/kg
91.98
0.62
TAC,
chloride,
pH,
viscosity
electric
conductivity
determined
1.24
0.03,
1.21
0.17
7.50
0.55
mPa
4675.33
57.74
µS.cm−1,
After
storing
extract
28
days
in
dark,
remained
71.57
0.64
75.00
0.26
33.42
0.41
%
71.45
0.21
Over
28-day
exposure
light,
19.09
0.10
34.89
2.28,
13.28
0.25
30.97
1.10,
application
aqueous
two-phase
system
resulted
preliminary
purification
extract,
providing
highest
purity
top
phase
cyanidin-3-glucoside
(68.85
1.05
%).
findings
revealed
is
promising
medium
industrial
anthocyanins,
suitable
anthocyanin-rich
obtained
with
NADES.
