European Polymer Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113910 - 113910
Published: March 1, 2025
Language: Английский
Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 8, 2025
Nozaki–Hiyama–Kishi (NHK) reactions offer a mild approach for the formation of alcohol motifs through radical-polar crossover-based pathways from various radical precursors. However, application multicomponent NHK-type reactions, which allow multiple bonds in single step, has been largely restricted to bulky alkyl precursors, thus limiting their expanded utilization. Herein, we disclose general three-component reaction enabled by delayed crossover, efficiently tolerates plethora precursors that were previously unavailable. This method enables modular assembly versatile homoallylic alcohols feedstock chemicals with excellent chemo-, regio-, diastereo-, and enantioselectivities step. Experimental studies density functional theory (DFT) calculations reveal kinetically favored an allylchromium(III) species is paramount enforcing crossover over direct addition. Finally, straightforward transformations applications products demonstrated, showcasing synthetic utility this method.
Language: Английский
Citations
1
Organic Letters, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 10, 2025
Described herein is the trimethylsilylation of various nucleophiles using a combination HCF3 and NaHMDS. This facile protocol enables rapid construction alkynylsilanes, silyl enol ethers, etc., under mild conditions. Detailed mechanistic studies indicate that trimethylsilicon intermediate formed in situ can be readily attacked by nucleophiles, with activation base NaHMDS difluorocarbene. work first utilizes structure HMDS as silicon source terminal alkynes.
Language: Английский
Citations
0
European Polymer Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113910 - 113910
Published: March 1, 2025
Language: Английский
Citations
0