Genetic Factors and Antibodies to Vibrio cholerae in Diarrhea Patients, Central Hospital Auchi, Nigeria DOI
Mathew Folaranmi Olaniyan, Kemi Felicia Ajiboye, Tolulope Busayo Ojediran

et al.

Journal of Integrated Health Sciences, Journal Year: 2024, Volume and Issue: 12(2), P. 104 - 109

Published: July 1, 2024

Introduction: Cholera, caused by the bacterium Vibrio cholerae , poses a significant public health challenge, particularly in regions with inadequate sanitation. Cholera outbreaks are common low-resource settings, and understanding genetic immunological factors influencing susceptibility severity is critical for developing targeted strategies. Aims: This study investigates prevalence of among diarrhea patients at Central Hospital Southsouth, Nigeria. It aims to examine specific antibody responses associated cholera severity. Material Methods: cross-sectional included 300 presenting acute between January December 2023. Stool blood samples were collected analyzed * V. isolation, polymorphisms, levels. The analysis focused on toll-like receptor 4 (rs4986790) interleukin-10 (rs1800896) polymorphisms. Specific IgG, IgM, IgA levels against measured. Results: was identified 18% patients, serotypes O1 O139 being most prevalent. Genetic revealed associations polymorphisms increased infection. In contrast, higher reduced disease Infected exhibited elevated cholerae, which correlated milder outcomes. Conclusions: findings highlight influence determining suggests that screening could identify high-risk individuals, facilitating interventions. Improving water, sanitation, hygiene infrastructure remains essential prevention. While design limits ability draw causal inferences, offers valuable insights into determinants cholera, underscoring need integrated strategies effectively manage control outbreaks.

Language: Английский

Proximity care pathways and digitalization: opportunities and concerns for medication safety management—Insights from the ProSafe study on community perspectives DOI Creative Commons
Francesca Moretti, Maria Angela Mazzi,

Sara Montresor

et al.

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 20, 2025

Establishing proximity care pathways, including the digitalization of healthcare, is valuable for sustainable management Non-Communicable Diseases (NCDs) and Patient-Centered Care (PCC) promotion. However, new safety concerns, particularly in therapy management, may arise. The Community-Based Participatory Research (CBPR) "ProSafe" aims at (i) explore stakeholders' perspectives on medication (ii) analyze which determinants affect community's perspective. A survey was co-developed with a Patient Safety Council (PSC) support pharmaceutical company. purposeful sampling strategy implemented to recruit individuals aged 18 older. Data were collected using dedicated online platform; differences between patients' healthy people's explored. Preliminary multiple regression analyses performed examine how sociodemographic factors, clinical data level outcomes linear probit models, accounting nature each outcome variable. models combined into equations Conditional Mixed Process (CMP) approach. 417 completed (81.0% affected by disease). positive attitude towards shifting administration from hospital home setting observed even if significantly higher proportion patients compared raised concerns regarding potential negative impact doctor-patient relationship (47.0% vs. 32.9%, p < 0.01). Additionally, 63.7% reported they would feel less supported process. usefulness telehealth, tele-pharmacy drug rated (mean value 1.3 1.5 0.01); 43.9% excessive responsibility placed them digital traditional healthcare. Health status education variables most frequently associated significant impacts across outcomes. perspective development pathways provided insights fears, limitations that could effectiveness this important shift healthcare delivery. Effectively addressing these issues essential truly bring disease closer their living environments while ensuring community becomes co-creators implementation care, fostering health equity patient autonomy.

Language: Английский

Citations

0
Ready or Not? The Emergency Preparedness State-of-art Among Italian Public Health Medical Residents DOI
Nunzio Zotti, Stefano Guicciardi,

Francesca Di Serafino

et al.

Disaster Medicine and Public Health Preparedness, Journal Year: 2024, Volume and Issue: 18

Published: Jan. 1, 2024

Italy often experiences major events, such as earthquakes, floods, and migrant shipwrecks. Current future global challenges for health workers are made up by climate change, pandemics, wars. In this work, we will assess the state-of-art of training interest towards these among Italian post-degree public schools.

Language: Английский

Citations

0
SDMPH 10-year Anniversary Conference Modified Delphi Study DOI
Eric S. Weinstein, Joseph Cuthbertson, Frederick M. Burkle

et al.

Disaster Medicine and Public Health Preparedness, Journal Year: 2024, Volume and Issue: 18

Published: Jan. 1, 2024

Abstract Objectives The SDMPH 10-year anniversary conference created an opportunity for a researcher to present at professional association advance their research by seeking consensus of statements using Delphi methodology. Methods Conference attendees and members who did not attend the were identified as experts. Experts rated agreement each statement on 7- point linear numeric scale. Consensus amongst experts was defined standard deviation < = 1. Presenters submitted relevant advancing authors edit fit formatting. Statements attaining included in final report after first round. Those moved second round which shown mean response expert panel own reconsider rating that If reconsideration attained consensus, these report. This process repeated third Results 37 agreed participate round; 35 completed round, 34 consensus; 3 attain consensus. Conclusions A technique used establish presenters guide future education, research, training.

Language: Английский

Citations

0
Mapping Rural Household Vulnerability to Flood-Induced Health Risks in Disaster-Stricken Khyber Pakhtunkhwa, Pakistan DOI Open Access

Ashfaq Ahmad Shah,

Wahid Ullah, Nasir Abbas Khan

et al.

Sustainability, Journal Year: 2024, Volume and Issue: 16(23), P. 10578 - 10578

Published: Dec. 3, 2024

This study maps the rural household vulnerability to flood-induced health risks in flood-affected Khyber Pakhtunkhwa (KPK), Pakistan, focusing on devastating 2022 flood. Using data from 600 households severely impacted districts of province (including Charsadda and Nowshera), this research examines influence demographic, socioeconomic, infrastructural factors vulnerability. assesses flooding issues using logistic regression. The current findings revealed that female-headed households, those with younger heads, families lower educational levels are particularly vulnerable. Income disparities significantly shape coping capacity, wealthier more likely adopt effective risk-mitigation strategies. Proximity functioning healthcare facilities emerged as a crucial factor reducing vulnerability, these faced fewer hazards. Conversely, areas where water infrastructure were damaged experienced higher disease outbreaks, including cholera malaria, due contamination inadequate sanitation. highlights urgent need for resilient infrastructure, strengthened public systems, improved education, enhanced sanitation services mitigate risks. Policymakers urged sustainable development practices by adopting gender-sensitive disaster management strategies, prioritizing initiatives, fostering community support networks enhance resilience future flood events KPK.

Language: Английский

Citations

0
Genetic Factors and Antibodies to Vibrio cholerae in Diarrhea Patients, Central Hospital Auchi, Nigeria DOI
Mathew Folaranmi Olaniyan, Kemi Felicia Ajiboye, Tolulope Busayo Ojediran

et al.

Journal of Integrated Health Sciences, Journal Year: 2024, Volume and Issue: 12(2), P. 104 - 109

Published: July 1, 2024

Introduction: Cholera, caused by the bacterium Vibrio cholerae , poses a significant public health challenge, particularly in regions with inadequate sanitation. Cholera outbreaks are common low-resource settings, and understanding genetic immunological factors influencing susceptibility severity is critical for developing targeted strategies. Aims: This study investigates prevalence of among diarrhea patients at Central Hospital Southsouth, Nigeria. It aims to examine specific antibody responses associated cholera severity. Material Methods: cross-sectional included 300 presenting acute between January December 2023. Stool blood samples were collected analyzed * V. isolation, polymorphisms, levels. The analysis focused on toll-like receptor 4 (rs4986790) interleukin-10 (rs1800896) polymorphisms. Specific IgG, IgM, IgA levels against measured. Results: was identified 18% patients, serotypes O1 O139 being most prevalent. Genetic revealed associations polymorphisms increased infection. In contrast, higher reduced disease Infected exhibited elevated cholerae, which correlated milder outcomes. Conclusions: findings highlight influence determining suggests that screening could identify high-risk individuals, facilitating interventions. Improving water, sanitation, hygiene infrastructure remains essential prevention. While design limits ability draw causal inferences, offers valuable insights into determinants cholera, underscoring need integrated strategies effectively manage control outbreaks.

Language: Английский

Citations

0