Neuropsychiatric symptoms of post-COVID-19 condition in Mexican healthcare personnel. DOI Creative Commons
David Ruíz-Ramos, Cecilia Yazmin Alonso-García,

Roberto Esteban Salazar-Rifka

et al.

Horizonte Sanitario, Journal Year: 2023, Volume and Issue: 23(1), P. 11 - 19

Published: Dec. 16, 2023

Objective: The aim of the present study was to identify anxiety and depression in health personnel who suffered COVID-19, associate them with blood inflammatory markers. Materials methods: design this descriptive cross-sectional. We evaluated 51 healthcare workers survived COVID-19 disease Hamilton scales for depression, also we calculated markers (systemic immune-inflammation index, SII; monocyte lymphocyte ratio, MLR; platelet PLR; neutrophil NLR) using venous samples. This carried out from August 2021 December 2022. Statistical analysis performed SPSS v. 26. Results: Our included personnel, females (n=29) males (n=22). mean age 40.54 ± 11.00 years. most frequent acute symptoms presented were dysgeusia (n=20), anosmia (n=18), headache (n=17). common comorbidities overweight (n=24), obesity (n=22), hypertension (n=11). According Rating Scale Anxiety (HARS) Depression (HRSD) 72.5% (n=37) 51% (n=26) within respectively. Conclusions: In our study, observed a high frequency post condition. However, did not observe an association between (NLR, PLR, MLR, SII) post-COVID-19. suggest follow-up assessments post-COVID-19 condition, evaluate if mixed emotional disorders persist. Keywords: Anxiety; Depression; Mental disorders; Inflammation; COVID-19.

Language: Английский

Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study DOI Open Access
Callum Jackson, Iain Stewart, Tatiana Plekhanova

et al.

The Lancet Respiratory Medicine, Journal Year: 2023, Volume and Issue: 11(8), P. 673 - 684

Published: April 15, 2023

Language: Английский

Citations

24
Intervention modalities for brain fog caused by long-COVID: systematic review of the literature DOI Creative Commons
Alon Gorenshtein,

Tom Liba,

Liron Leibovitch

et al.

Neurological Sciences, Journal Year: 2024, Volume and Issue: 45(7), P. 2951 - 2968

Published: May 2, 2024

Language: Английский

Citations

9
Cognitive Impairment after Post-Acute COVID-19 Infection: A Systematic Review of the Literature DOI Open Access
Andrea Perrottelli, Noemi Sansone, Giulia Maria Giordano

et al.

Journal of Personalized Medicine, Journal Year: 2022, Volume and Issue: 12(12), P. 2070 - 2070

Published: Dec. 15, 2022

The present study aims to provide a critical overview of the literature on relationships between post-acute COVID-19 infection and cognitive impairment, highlighting limitations confounding factors. A systematic search articles published from 1 January 2020 July 2022 was performed in PubMed/Medline. We followed Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) guidelines. Only studies using validated instruments assessment impairment were included. Out 5515 screened records, 72 met inclusion criteria. available evidence revealed presence executive functions, speed processing, attention memory subjects recovered COVID-19. However, several reviewed should be highlighted: most small samples, not stratified by severity disease age, used as cross-sectional or short-term longitudinal design provided limited different domains. Few investigated neurobiological correlates deficits individuals Further with an adequate methodological are needed in-depth characterization

Language: Английский

Citations

35
Neurocognitive and Neuropsychiatric Sequelae in Long COVID-19 Infection DOI Creative Commons
Marta Almería, Juan Carlos Cejudo, Joan Deus

et al.

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(6), P. 604 - 604

Published: June 14, 2024

Objective: To characterize the cognitive profile of long COVID-19 subjects and its possible association with clinical symptoms, emotional disturbance, biomarkers, disease severity. Methods: We performed a single-center cross-sectional cohort study. Subjects between 20 60 years old confirmed infection were included. The assessment was 6 months following hospital or ambulatory discharge. Excluded those prior neurocognitive impairment severe neurological/neuropsychiatric disorders. Demographic laboratory data extracted from medical records. Results: Altogether, 108 participants included, 64 male (59.25%), mean age 49.10 years. patients classified into four groups: non-hospitalized (NH, n = 10), hospitalized without Intensive Care Unit (ICU) oxygen therapy (HOSPI, 21), ICU but (OXY, 56), (ICU, 21) patients. In total, 38 (35.18%) reported Subjective Cognitive Complaints (SCC). No differences found considering illness severity groups. Females had more persistent symptoms SCC than males. Persistent dyspnea headache associated higher scores in anxiety depression. fatigue, anxiety, depression worse overall cognition. Conclusions: regarding post-COVID-19 infection. not performance, frequent independent Fatigue, linked to poorer function. Tests for attention, processing speed, executive function most sensitive detecting changes these

Language: Английский

Citations

3
Cognitive Profile of SARS-cov-2 Recovered Patients: A Comprehensive Analysis of Persistent Dysfunctions in Long COVID DOI Open Access

Alisson Rafael Oliveira Lima,

Beatriz Cavendish,

Bianca Silva Pinto

et al.

Published: July 27, 2023

Long Covid is a term used for patients who have recovered from COVID-19 but exhibit persistent cognitive dysfunction, including mental confusion, difficulties in attention, impairment executive functions and slow movements, among other common symptoms. A study was conducted with 65 had positive RT-PCR diagnosis reported symptoms of impairment, such as memory loss attention after recovery. The underwent neuropsychological evaluation completed questionnaires on cognition, mood, quality life. During the screening, 71% showed alterations, deficits visual (69%), language (54%), visuospatial construction (49%), verbal episodic (37%), (36%), attentional abilities (34%), premorbid intelligence (12%). It important to highlight need treatments further studies understand long-term side effects this disease.

Language: Английский

Citations

1
Aftereffects in Epigenetic Age Related to Cognitive Decline and Inflammatory Markers in Healthcare Personnel with Post-COVID-19: A Cross-Sectional Study DOI Creative Commons
Germán Alberto Nolasco-Rosales,

Cecilia Yazmin Alonso-García,

David Gustavo Hernández-Martínez

et al.

International Journal of General Medicine, Journal Year: 2023, Volume and Issue: Volume 16, P. 4953 - 4964

Published: Oct. 1, 2023

Epigenetic age and inflammatory markers have been proposed as indicators of severity mortality in patients with COVID-19. Furthermore, they associated the occurrence neurological symptoms, psychiatric manifestations, cognitive impairment. Therefore, we aimed to explore possible associations between epigenetic age, neuropsychiatric manifestations (neutrophil-lymphocyte ratio [NLR], platelet-lymphocyte [PLR], monocyte-lymphocyte [MLR], systemic immune-inflammation index [SII]) healthcare personnel post-COVID condition.We applied Montreal Cognitive Assessment (MoCA) Mini-Mental State Examination (MMSE) tests 51 Mexican workers post-COVID-19 condition; also estimated their using PhenoAge calculator.The participants had a condition that lasted median 14 months (range: 1-20). High NLR (>1.73) association mild impairment by MMSE (p=0.013). Likewise, high MLR (>0.24) were language domain MOCA (p=0.046). Low PLR (<103.9) was related delayed recall (p=0.040). Regarding comorbidities, hypertension SII (p=0.007), overweight (p=0.047) alcoholism (p=0.043). Interestingly, observed low (<1.35) levels increased duration (p=0.027, p=0.031). increases (OR=1.11, p=0.049), (OR=1.12, p=0.035) p=0.030).We neurocognitive changes condition. Future research is required assess mental physical health individuals symptoms.

Language: Английский

Citations

1
The Impact of Long COVID on Cognitive Performance and Sleep Quality: An Analysis of the Rancagua Chilean Study (RACHIS) DOI Open Access
Héctor Aceituno,

Andrea Barrancas,

Fernando Quiroz-Bravo

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 27, 2024

Background Infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can lead to prolonged symptoms post-recovery, commonly known as long-term disease 2019 (COVID-19) or "long COVID." Neuropsychiatric consequences of long COVID include cognitive dysfunction and sleep disturbances, which significantly impair daily living. This study aimed explore impact on performance quality in patients receiving outpatient care. Material methods involved a random sample 138 363 patients, corresponding 38% cohort, who tested positive for SARS-CoV-2 via polymerase chain reaction (PCR) between May 2020 April 2021. These unvaccinated, non-hospitalized individuals, predominantly exhibiting mild symptoms, were prospectively assessed 11 months post-positive PCR test. After informed consent, demographic data, memory, concentration impairment levels collected through interviews. Participants reporting underwent Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MOCA), Pittsburgh Sleep Quality Index. Statistical analyses conducted, including Student's t-test, Chi-square, Fisher's test, Kruskal-Wallis Pearson correlation coefficient, significance threshold set at p<0.05. Results Of participants, 76 (55.1%) female 62 (44.9%) male. The mean age was 45.9 years (± 13.0), an average educational attainment 10.4 3.7). Roughly 50% reported significant memory issues (p<0.001). Thirty-three participants detailed assessments, revealing 2:1 female-to-male ratio higher prevalence depression participants. deficits diagnosed five (15.2%) MMSE 26 (78.8%) MOCA notable visuospatial/executive functions, language repeat, deferred recall A lower level correlated (p=0.03). Conclusion findings reveal that impairments, consequence COVID-19, persist up post-infection. test proved more effective diagnosing these requires adjustments based background. parameters remained largely unaffected this likely attributed nature initial management disease.

Language: Английский

Citations

0
Poor sleep quality may trigger cognitive deficits after recovery from COVID-19 DOI Creative Commons
Anna Carnes, Gerard Piñol‐Ripoll, Mar Ariza

et al.

Frontiers in Psychology, Journal Year: 2024, Volume and Issue: 15

Published: May 27, 2024

Objective In the present study, we aimed to assess cognition of post-COVID-19 condition (PCC) participants in relation their subjective sleep quality (Pittsburgh Sleep Quality Index, PSQI) and analyse possible moderators this effect, such as life (European Life-5 Dimensions, EQ-5D), fatigue (Chadler Fatigue Questionnaire, CFQ), cognitive reserve (Cognitive Reserve CRC), complaints (Memory Failures Everyday MFE-30). Methods We included 373 individuals with PCC 126 healthy controls (HCs) from NAUTILUS Project (NCT05307549 NCT05307575) who were assessed a comprehensive neuropsychological battery various questionnaires. Results found that poor had 4.3% greater risk immediate verbal memory deficits than those good quality, indicated by odds ratio (OR) 1.043 confidence interval (CI) 1.023–1.063. Additionally, disorders was multiplied 2.4 when EQ-5D score low (OR 0.33; CI 0.145–0.748), they lower delayed visual CRC 0.963; 0.929–0.999). With respect processing speed, 6.7% MFE increased 1.059; 1.024–1.096), slowed speed tripled 0.021; 0.003–0.141). Conclusion These results indicate is potential trigger for deficits. Therapeutic strategies maximize could include reducing disturbances perhaps impairment individuals.

Language: Английский

Citations

0
The effects of sleep disturbance on dyspnoea and impaired lung function following COVID-19 hospitalisation: a prospective multi-centre cohort study DOI Open Access
Callum Jackson, Iain Stewart, Tatiana Plekhanova

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2022, Volume and Issue: unknown

Published: Dec. 14, 2022

Abstract Background Sleep disturbance is common following hospitalisation both for COVID-19 and other causes. The clinical associations are poorly understood, despite it altering pathophysiology in scenarios. We, therefore, investigated whether sleep associated with dyspnoea along relevant mediation pathways. Methods parameters were assessed a prospective cohort of patients (n=2,468) hospitalised the United Kingdom 39 centres using subjective device-based measures. Results compared to matched UK biobank evaluated multivariable linear regression. Findings 64% (456/714) participants reported poor quality; 56% felt their quality had deteriorated at least 1-year hospitalisation. Compared cohort, regularity (44.5 vs 59.2, p<0.001) efficiency (85.4% 88.5%, lower whilst period duration was longer (8.25h 7.32h, p<0.001). Overall (effect estimate 4.2 (3.0–5.5)), deterioration 3.2 (2.0–4.5)), 5.9 (3.7–8.1)) impaired lung function (FEV 1 FVC). Depending on metric, anxiety mediated 13–42% effect muscle weakness 29-43% this effect. Interpretation dyspnoea, It could have similar effects causes where prevalent. Funding Research Innovation, National Institute Health Research, Engineering Physical Sciences Council.

Language: Английский

Citations

1
Cognitive Profile of Sars-Cov-2 Recovered Patients: A Comprehensive Analysis of Persistent Dysfunctions in Long Covid DOI

Alisson Rafael Oliveira Lima,

Beatriz Cavendish,

Pedro Henrique Rodrigues da Silva

et al.

Published: Jan. 1, 2023

Long Covid is a term used for patients who have recovered from COVID-19 but exhibit persistent cognitive dysfunction, including mental confusion, difficulties in attention, impairment executive functions and slow movements, among other common symptoms. A study was conducted with 65 had positive RT-PCR diagnosis reported symptoms of impairment, such as memory loss attention after recovery. The underwent neuropsychological evaluation completed questionnaires on cognition, mood, quality life. During the screening, 71% showed alterations, deficits visual (69%), language (54%), visuospatial construction (49%), verbal episodic (37%), (36%), attentional abilities (34%), premorbid intelligence (12%). It important to highlight need treatments further studies understand long-term side effects this disease.

Language: Английский

Citations

0