Microglia harmonize the cerebral lymphoid system clearance in perioperative neurocognitive disorders by the ATP-AMP-ADO pathway

Medical Hypotheses, Journal Year: 2024, Volume and Issue: 190, P. 111430 - 111430

Published: July 11, 2024

Perioperative neurocognitive disorder (PND) is a cognitive dysfunction that often occurs after surgery, particularly in elderly patients. The cerebral lymphatic system, which acts as an immune scavenger for the nervous may play crucial role development of PND. Recent studies suggest microglia, by sensing metabolites ATP (adenosine triphosphate), inhibit neuronal electrical activity. This inhibition impact driving force system and impair its scavenging function. Investigating microglia regulating through ATP-AMP monophosphate)-ADO (adenosine) pathway could provide new insights into pathogenesis PND identify novel targets strategies prevention treatment.

Language: Английский

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Neuroinflamação Hipocampal e Distúrbios de memória na Síndrome Pós-COVID-19

Revista Neurociências, Journal Year: 2024, Volume and Issue: 32, P. 1 - 26

Published: Aug. 14, 2024

Introdução. Este artigo aborda as implicações neurocognitivas da síndrome pós-COVID-19, com ênfase na neuroinflamação hipocampal e seu possível impacto nos distúrbios de memória. Explorando evidências existentes sobre a relação entre infecção por COVID-19 alterações neurocognitivas, busca-se aprofundar compreensão desses fenômenos, destacando importância pesquisas mais detalhadas nesse campo crítico saúde neurológica. Objetivo. Analisar repercussões foco específico memória, visando dos mecanismos patológicos associados. Método. A pesquisa foi conduzida utilizando estratégias busca em bases dados como MEDLINE/PubMed, Science Direct Web of Science. Os termos seguiram padrões MeSH DeCS. questão norteadora o pós-COVID-19 nas funções Resultados. ativação microglial no hipocampo, associada ao comprometimento cognitivo vírus, pode explicar sintomas neuropsiquiátricos sobreviventes COVID-19. Estudos indicam que inflamação sistêmica, presente sepse grave, desencadear neurodegeneração, possivelmente compartilhando semelhanças Conclusão. Compreender lesões cerebrais causadas pela guiar intervenções terapêuticas, incluindo moduladores citocinas, para mitigar queixas neuropsiquiátricas. Melhorar complicações reduzirá doença, enquanto neuropatologia fornecer insights valiosos outras condições neurodegenerativas.

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Exploring the effects of COVID-19 on verbal memory function in schizophrenia: Multiple case study and brief literature review

Applied Neuropsychology Adult, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 12

Published: Oct. 14, 2024

Individuals recovering from COVID-19 may experience persistent impairment in verbal memory performance, potentially due to illness-related hippocampal injury. Although dysfunction is central schizophrenia, the interactions between this vulnerability and remain unclear, with no imaging studies addressing issue to-date. To explore gap generate hypotheses for future research, we adopted a multiple case study approach. Two pairs of individuals an ICD-10 diagnosis schizophrenia were selected, each consisting one positive anamnesis without. We calculated Reliable Change Index estimate clinical significance performance changes, annualized change rates volumes assessed against normative data. Compared their matches, cases did not show mutually consistent changes performance: experienced significant decline learning, while other showed general normalization test scores. Left comparatively slowed increase, right hippocampi decreased volume, although these atrophy exceed those expected population samples. Based on findings, hypothesize that alone does lead schizophrenia. Instead, relationship diseases depend additional factors. Our differed body mass index, systolic blood pressure, sex, phase illness, whole grey matter volume trajectories, leading us variables represent predictors or moderators relationship.

Language: Английский

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Cognitive impact and brain structural changes in long COVID patients: a cross-sectional MRI study two years post infection in a cohort from Argentina

BMC Neurology, Journal Year: 2024, Volume and Issue: 24(1)

Published: Nov. 18, 2024

Abstract Objective Long COVID is a condition characterised by persistent symptoms after SARS-CoV-2 infection, with neurological manifestations being particularly frequent. Existing research suggests that long patients not only report cognitive but also exhibit measurable impairment. Neuroimaging studies have identified structural alterations in brain regions linked to functions. However, most of these focused on within months their initial infection. This study aims explore the longer-term effects and changes patients, approximately two years post-infection, cohort from San Martín, Buenos Aires, Argentina. Methods We conducted cross-sectional involving 137 participants: 109 28 healthy controls. The participants underwent an clinical assessment, completed structured questionnaire standardised scales, had MRI scan. Structural images were processed via FreeSurfer FSL obtain volumetric measures for subcortical cortical regions, along regional thickness. Differences between groups variables analysed using ANCOVA, permutation tests applied correct multiple comparisons. Results reported such as memory problems fog, higher levels fatigue reduced quality life compared Despite subjective complaints, did reveal significant differences groups, except TMT-A ( p = 0.05). analysis revealed decreased volume cerebellum 0.03), lingual gyrus 0.04), inferior parietal thickness several areas, including left right postcentral gyri 0.02, 0.03) precuneus 0.01, 0.02). Conclusions highlights enduring impact physical activity, specific post-infection. Although show clear impairment, observed atrophy reduction emphasize need comprehensive interventions further longitudinal understand long-term cognition health.

Language: Английский

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Long COVID: A Molecular, Cellular and Histopathology Overview

Journal of Biosciences and Medicines, Journal Year: 2023, Volume and Issue: 11(09), P. 90 - 113

Published: Jan. 1, 2023

Long COVID has been studied as different sequelae that some individuals can develop after the acute phase of disease. Persistent symptoms such dry cough, fatigue, and dyspnea remain six months COVID-19 cure. Others lung fibrosis, kidney injury, thrombotic risk also are observed. Here, a deep review each human organ system infected by virus was performed aiming to show how molecules expression cell signaling induce organism cure or injuries and, subsequently sequelae. The suggests importance public health surveillance for these cases including more comprehensive analysis molecular biology tools clarify assist in prognosis, treatment, preventive methods potentially serious disorders post-COVID-19 patients.

Language: Английский

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