Recent advances and future perspectives in small molecule JAK2 inhibitors DOI
Muhammad Yasir, Jongseon Choe, Mubashir Hassan

et al.

Future Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 17

Published: May 20, 2025

The Janus kinase (JAK)/Signal Transducer and Activator of Transcription (STAT) signaling pathway is essential for controlling immune function, blood cell formation, growth. Dysregulation this implicated in various diseases, including hematologic malignancies, autoimmune disorders, chronic inflammatory conditions. This review provides a comprehensive overview the structural functional aspects JAK/STAT signaling, with particular focus on role JAK2. manuscript explores primary regulators pathway, such as Suppressors Of Cytokine Signaling (SOCS), Protein Inhibitors Activated STATs (PIAS), Tyrosine Phosphatases (PTPs), which play crucial maintaining cellular balance stability. Additionally, therapeutic landscape JAK2 inhibitors explored, covering both approved investigational drugs, their mechanisms action, efficacy, safety profiles. Emerging strategies drug repositioning using computational approaches experimental validation are also highlighted. By integrating insights from molecular docking studies, machine learning models, assays, emphasizes potential disease management.

Language: Английский

Recent advances and future perspectives in small molecule JAK2 inhibitors DOI
Muhammad Yasir, Jongseon Choe, Mubashir Hassan

et al.

Future Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 17

Published: May 20, 2025

The Janus kinase (JAK)/Signal Transducer and Activator of Transcription (STAT) signaling pathway is essential for controlling immune function, blood cell formation, growth. Dysregulation this implicated in various diseases, including hematologic malignancies, autoimmune disorders, chronic inflammatory conditions. This review provides a comprehensive overview the structural functional aspects JAK/STAT signaling, with particular focus on role JAK2. manuscript explores primary regulators pathway, such as Suppressors Of Cytokine Signaling (SOCS), Protein Inhibitors Activated STATs (PIAS), Tyrosine Phosphatases (PTPs), which play crucial maintaining cellular balance stability. Additionally, therapeutic landscape JAK2 inhibitors explored, covering both approved investigational drugs, their mechanisms action, efficacy, safety profiles. Emerging strategies drug repositioning using computational approaches experimental validation are also highlighted. By integrating insights from molecular docking studies, machine learning models, assays, emphasizes potential disease management.

Language: Английский

Citations

0