Micromachines, Journal Year: 2024, Volume and Issue: 15(12), P. 1529 - 1529
Published: Dec. 23, 2024
Organ transplantation, biomimetic organ models, and the restoration of damaged or eviscerated tissues have been key goals in surgical medical research since their inception [...]
Language: Английский
Journal of Tissue Engineering, Journal Year: 2025, Volume and Issue: 16
Published: Jan. 1, 2025
The field of three dimensional (3D) bioprinting has witnessed significant advancements, with bioinks playing a crucial role in enabling the fabrication complex tissue constructs. This review explores innovative that are currently shaping future 3D bioprinting, focusing on their composition, functionality, and potential for engineering, drug delivery, regenerative medicine. development bioinks, incorporating natural synthetic materials, offers unprecedented opportunities personalized However, rapid technological progress raises regulatory challenges regarding safety, standardization, long-term biocompatibility. paper addresses these challenges, examining current frameworks need updated guidelines to ensure patient safety product efficacy. By highlighting both hurdles, this comprehensive overview landscape emphasizing necessity cross-disciplinary collaboration between scientists, clinicians, bodies achieve successful clinical applications.
Language: Английский
Citations
5
Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 348, P. 122845 - 122845
Published: Oct. 17, 2024
Polysaccharide hydrogels, which can mimic the natural extracellular matrix and possess appealing physicochemical biological characteristics, have emerged as significant bioinks for 3D bioprinting. They are highly promising applications in tissue engineering regenerative medicine because of their ability to enhance cell adhesion, proliferation, differentiation a manner akin cellular environment. This review comprehensively examines fabrication methods, polysaccharide hydrogel-driven bioprinting, underscoring its potential engineering, drug delivery, medicine. To contribute pertinent knowledge future research this field, critically key aspects, including chemistry carbohydrates, manufacturing techniques, formulation bioinks, characterization polysaccharide-based hydrogels. Furthermore, explores primary advancements 3D-printed encompassing delivery systems with controlled release kinetics targeted therapy, along tissue-engineered constructs bone, cartilage, skin, vascular regeneration. The use these bioprinted hydrogels innovative fields, disease modeling screening, is also addressed. Despite notable progress, challenges, modulating properties polysaccharides, enhancing bioink printability mechanical properties, achieving long-term vivo stability, been highlighted.
Language: Английский
Citations
11
Journal of Functional Biomaterials, Journal Year: 2025, Volume and Issue: 16(1), P. 28 - 28
Published: Jan. 16, 2025
The application of three-dimensional (3D) printing/bioprinting technologies and cell therapies has garnered significant attention due to their potential in the field regenerative medicine. This paper aims provide a comprehensive overview 3D technology therapies, highlighting results diverse medical applications, while also discussing capabilities limitations combined use. synergistic combination printing cellular been recognised as promising innovative approach, it is expected that these will progressively assume crucial role treatment various diseases conditions foreseeable future. review concludes with forward-looking perspective on future impact technologies, revolutionize medicine through enhanced tissue repair organ replacement strategies.
Language: Английский
Citations
1
Gut, Journal Year: 2025, Volume and Issue: unknown, P. gutjnl - 333885
Published: March 3, 2025
Background To treat liver failure, three-dimensional (3D) bioprinting is a promising technology used to construct hepatic tissue models. However, current research on of models primarily relies conventional single-cell-based bioprinting, where individual functional hepatocytes are dispersed and isolated within hydrogels, leading insufficient treatment outcomes due inadequate cell functionality. Objective Here, we aim bioprint model using hepatocyte organoids (HOs) evaluate its liver-specific functions in vitro vivo . Design Human chemically induced pluripotent stem cells (hCiPSCs) were as robust non-genome-integrative source produce highly viable HOs (hCiPSC-HOs). An oxygen-permeable microwell device was enhance oxygen supply, ensuring high viability promoting hCiPSC-HOs maturation. maintain the long-term biofunction hCiPSC-HOs, spheroid-based employed (3DP-HOs). 3DP-HOs intraperitoneally implanted mice with failure. Results demonstrated enhanced when compared fabricated exhibited gene profiles closely resembling while maintaining Moreover, implantation significantly improved survival CCl 4 -induced acute-on-chronic failure also Fah−/− reduced injury, inflammation fibrosis indices regeneration expression. Conclusion Our bioprinted exhibits remarkable therapeutic efficacy for holds great potential clinical field regenerative medicine.
Language: Английский
Citations
1
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1449 - 1449
Published: Feb. 9, 2025
Nanocellulose-based biomaterials are at the forefront of biomedicine, presenting innovative solutions to longstanding challenges in tissue engineering and wound repair. These advanced materials demonstrate enhanced mechanical properties improved biocompatibility while allowing for precise tuning drug release profiles. Recent progress design, fabrication, characterization these underscores their transformative potential biomedicine. Researchers employing strategic methodologies investigate characterize structure functionality nanocellulose In engineering, nanocellulose-based scaffolds offer opportunities replicate complexities native tissues, facilitating study effects on metabolism, vascularization, cellular behavior engineered liver, adipose, tumor models. Concurrently, has gained recognition as an dressing material, leveraging its ability deliver therapeutic agents via topical, transdermal, systemic pathways simultaneously promoting proliferation regeneration. The inherent transparency provides a unique advantage, enabling real-time monitoring healing progress. Despite advancements, significant remain large-scale production, reproducibility, commercial viability biomaterials. This review not only hurdles but also outlines directions future research, including need bioengineering dressings with scalable production incorporation novel functionalities clinical translation. By addressing key challenges, redefine biomedical material design unmet needs beyond.
Language: Английский
Citations
0
3D Printing and Additive Manufacturing, Journal Year: 2025, Volume and Issue: unknown
Published: March 7, 2025
Language: Английский
Citations
0
Tissue Engineering Part B Reviews, Journal Year: 2025, Volume and Issue: unknown
Published: April 8, 2025
Colorectal cancer (CRC) recurs at a striking rate, specifically in patients with liver metastasis. Dormant CRC cells disseminated following initial primary tumor resection or treatment often resurface years later to form aggressive, therapy-resistant tumors that result high patient mortality. Routine imaging-based screenings fail detect dormant cell clusters, and there are no overt symptomatic presentations, making major clinical challenge diagnose treat. Tissue engineering approaches ideally suited model enable the discovery of therapeutic vulnerabilities unique mechanistic dependencies CRC. Emerging evidence suggests tissue-engineered have been successfully used breast lung cancer. With responsible for second most cancer-related deaths worldwide commonly experiencing recurrence, it is essential expand dormancy models understand this phenomenon context Most published vitro simplify complex microenvironment two-dimensional culture systems elucidate dormancy-driving mechanisms. Building on foundation, future research should apply tissue methods growing field generate competent three-dimensional increase knowledge. This review summarizes current state models, highlighting techniques utilized give rise cells: nutrient depletion, anticancer drugs, physical extracellular matrix interactions, genetic manipulation. The metrics validate within each also consolidated demonstrate lack established standards ambiguity around comparing studies validated differently. these organized comprehensibility identify needs opportunities bioengineered address dormancy-driven mortality Impact Statement drives mortality, especially metastatic colorectal cancer, owing inability prior their recurrence. Lacking insights, modeling hindered. Here, we inducing goal consolidating findings reference. We highlight need advanced, better mimic organ-specific 3D New would breakthroughs understanding mechanisms driving progression reversal, thereby providing advances improve survival.
Language: Английский
Citations
0
ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 4, 2024
The integration of hydrogel-based bioinks with 3D bioprinting technologies presents an innovative approach to chronic wound management, which is particularly challenging treat because its multifactorial nature and high risk complications. Using precise deposition techniques, significantly alters traditional care paradigms by enabling the fabrication patient-specific dressings that imitate natural tissue properties. Hydrogels are notably beneficial for these applications their abundant water content mechanical properties, promote cell viability pathophysiological processes healing, such as re-epithelialization angiogenesis. This article reviews key printing significance in enhancing structural functional outcomes wound-care solutions. Challenges bioink viscosity, viability, printability addressed, along discussions on cross-linking stability constructs. potential revolutionize management rests capacity generate remedies expedite healing minimize infection risks. Nevertheless, further studies clinical trials necessary advance therapies from laboratory use.
Language: Английский
Citations
3
Materials Today Bio, Journal Year: 2024, Volume and Issue: 29, P. 101284 - 101284
Published: Oct. 2, 2024
Language: Английский
Citations
3
IGI Global eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 335 - 366
Published: April 25, 2025
Recently, Tissue engineering (TE) has been rapidly growing field in biomedical field, it provides the solutions to problem such as immunological rejection and a shortage of available donors. TE scaffolds encourage cell adhesion, proliferation, differentiation by simulating extracellular matrix with three-dimensional matrices. Current, advancements artificial intelligence (AI) nanotechnology have improved design, pore size, mechanical properties. However, lack ability vascularization, immune compatibility, scalability. In order address this issue, surface-functionalized anti-inflammatory cytokines IL-10 that can increase integration, less rejection, long-term performance. Therefore, is considered combination AI scaffold design will enhance bioactivity, strength, cellular behavior modeling. Regenerative medicine poised for revolution due significant scaffold-based TE.
Language: Английский
Citations
0