CTLA-4 rs5742909 but not ADAM33 rs2280091 is a Predictor Factor for COVID-19 Mortality DOI Creative Commons

Farzaneh Sheikhian,

Mohammad Golparvar, Iraj Ahmadi

et al.

Journal of Infection and Public Health, Journal Year: 2024, Volume and Issue: 18(1), P. 102618 - 102618

Published: Dec. 6, 2024

Research has demonstrated the association between susceptibility to coronavirus disease 2019 (COVID-19) and single nucleotide polymorphisms (SNPs). On other hand, cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) serves as a pivotal inhibitory receptor with substantial impact on advancement of viral infections. Besides, disintegrin metalloproteinase33 (ADAM33) gene is associated both asthma heightened airway responsiveness. Hence, this investigation sought elucidate potential CTLA-4 rs5742909 ADAM33 rs2280091 SNPs fatality rate COVID-19 across various variants severe acute respiratory syndrome 2 (SARS-CoV-2).

Language: Английский

Identification of nitrile-containing isoquinoline-related natural product derivatives as coronavirus entry inhibitors in silico and in vitro DOI Open Access
Nasim Shahhamzehei, Sara Abdelfatah,

Hannah Sabeth Schwarzer-Sperber

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 180, P. 117517 - 117517

Published: Oct. 1, 2024

Language: Английский

Citations

0
Immunoinformatics-Based Design of Broad-Spectrum Multi-Epitope Vaccines Targeting Mutations in Emerging SARS-CoV-2 Variants DOI Creative Commons
Xueyin Mei,

Wanrong Xie,

Xue Lin

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 14, 2024

Abstract The ongoing COVID-19 pandemic, intensified by emerging SARS-CoV-2 mutations, highlights the urgent need for enhanced vaccines. Despite considerable efforts in vaccine design, improvements are still required formulating vaccines targeting novel coronavirus. This study, utilized immunoinformatics and reverse vaccinology to design multi-epitope variations. B T cell epitopes were generated analyzing mutation sites of prevalent variant strains, two designed linking with different adjuvants. Interaction model four Toll-like receptors (TLR) revealed a relatively high affinity between immune receptors. Codon optimization computational cloning conducted validate robustness immunogenic simulations performed assess antigenicity antibody generation capability vaccine. L455S JN.1 its adjacent F456L on effectiveness against XBB that 15 structures maintained certain level binding affinity. study offers an immunological evaluation from mutation-centric perspective integrates co-evolutionary analysis effective various strains. methodologies applied this research can also be extended development other pathogens.

Language: Английский

Citations

0
A protein vaccine of RBD integrated with immune evasion mutation shows broad protection against SARS-CoV-2 DOI Creative Commons
Ran An, Hao Yang, Cong Tang

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Nov. 6, 2024

Abstract Variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continue to emerge and evade immunity, resulting in breakthrough infections vaccinated populations. There is an urgent need for the development vaccines with broad protective effects. In this study, we selected hotspot mutations receptor-binding domain (RBD) that contribute immune escape properties integrated them into original RBD protein obtain a complex (cRBD), found cRBDs have effects against SARS-CoV-2 variants. Three were designed our study. Compared BA.1 protein, induced production higher levels broader-spectrum neutralizing antibodies, suggesting stronger broader efficacy. viral challenge experiments, more effective than attenuating lung pathologic injury. Among three constructs, cRBD3 showed optimal broad-spectrum promising candidate vaccine. conclusion, immunization triggered immunity wide range variants, including those emerged after had completed designing cRBDs. This study preliminarily explores validates feasibility incorporating evasion expand activity spectrum antigen-induced antibodies.

Language: Английский

Citations

0
Safety and immunogenicity of PIKA-adjuvanted recombinant SARS-CoV-2 spike protein subunit vaccine as a booster against SARS-CoV-2: a phase II, open-label, randomized, double-blinded study DOI Creative Commons

Rachael Song-Qi Lim,

Xiangyan Qiu,

Edison Alberto

et al.

Clinical and Experimental Vaccine Research, Journal Year: 2024, Volume and Issue: 13(4), P. 329 - 329

Published: Jan. 1, 2024

This study evaluated the safety and immunogenicity of PIKA-adjuvanted recombinant severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein subunit vaccine as a booster dose for healthy adults who had previously received two or more doses an inactivated disease 2019 (COVID-19) vaccine.

Language: Английский

Citations

0
CTLA-4 rs5742909 but not ADAM33 rs2280091 is a Predictor Factor for COVID-19 Mortality DOI Creative Commons

Farzaneh Sheikhian,

Mohammad Golparvar, Iraj Ahmadi

et al.

Journal of Infection and Public Health, Journal Year: 2024, Volume and Issue: 18(1), P. 102618 - 102618

Published: Dec. 6, 2024

Research has demonstrated the association between susceptibility to coronavirus disease 2019 (COVID-19) and single nucleotide polymorphisms (SNPs). On other hand, cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) serves as a pivotal inhibitory receptor with substantial impact on advancement of viral infections. Besides, disintegrin metalloproteinase33 (ADAM33) gene is associated both asthma heightened airway responsiveness. Hence, this investigation sought elucidate potential CTLA-4 rs5742909 ADAM33 rs2280091 SNPs fatality rate COVID-19 across various variants severe acute respiratory syndrome 2 (SARS-CoV-2).

Language: Английский

Citations

0