Monophosphate Derivatives of Luteolin and Apigenin as Efficient Precursors with Improved Oral Bioavailability in Rats DOI Creative Commons
Shih‐Hsiung Wu, Shang‐Ta Wang, Guan‐Yuan Chen

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(12), P. 1530 - 1530

Published: Dec. 13, 2024

Luteolin (Lut) and apigenin (Apn), flavones present in various edible plants, exhibit diverse antioxidant pharmacological activities but have limited vivo efficacy due to low water solubility poor bioavailability. Here, we generated luteolin monophosphate derivatives (LutPs ApnPs) individually via microbial biotransformation. We then characterized their physicochemical properties evaluated vitro pharmacokinetics Both LutPs ApnPs showed enhanced dissolution remained stable simulated gastrointestinal conditions. Additionally, they efficiently reverted parental forms alkaline phosphatase Caco-2 cells. Following oral administration rats, exhibited higher plasma exposure both aglycone conjugated compared Lut Apn. Notably, the biotransformation of Apn was observed all apigenin-related groups. Our study suggests that flavone monophosphates are effective alternatives with bioavailability, providing insights for potential application emerging bioactive nutraceuticals.

Language: Английский

Administration route-dependent pharmacokinetic and biopharmaceutical features of steppogenin DOI

Ji‐Hoon Lee,

Minyeong Pang,

So Yeon Jeon

et al.

Journal of Pharmaceutical Investigation, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

Language: Английский

Citations

1
Apigenin alleviates inflammation as a natural IRAK4 inhibitor DOI

Pianchou Gongpan,

Tingting Xu, Yufei Zhang

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: 139, P. 156519 - 156519

Published: Feb. 18, 2025

Language: Английский

Citations

0
Effect of apigenin on seizure susceptibility, parvalbumin immunoreactivity, and GABAA receptor expression in the hippocampal neurons in mice DOI
Katarzyna Socała, Edyta Kowalczuk-Vasilev, Małgorzata Matysek

et al.

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177548 - 177548

Published: March 1, 2025

Language: Английский

Citations

0
Monophosphate Derivatives of Luteolin and Apigenin as Efficient Precursors with Improved Oral Bioavailability in Rats DOI Creative Commons
Shih‐Hsiung Wu, Shang‐Ta Wang, Guan‐Yuan Chen

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(12), P. 1530 - 1530

Published: Dec. 13, 2024

Luteolin (Lut) and apigenin (Apn), flavones present in various edible plants, exhibit diverse antioxidant pharmacological activities but have limited vivo efficacy due to low water solubility poor bioavailability. Here, we generated luteolin monophosphate derivatives (LutPs ApnPs) individually via microbial biotransformation. We then characterized their physicochemical properties evaluated vitro pharmacokinetics Both LutPs ApnPs showed enhanced dissolution remained stable simulated gastrointestinal conditions. Additionally, they efficiently reverted parental forms alkaline phosphatase Caco-2 cells. Following oral administration rats, exhibited higher plasma exposure both aglycone conjugated compared Lut Apn. Notably, the biotransformation of Apn was observed all apigenin-related groups. Our study suggests that flavone monophosphates are effective alternatives with bioavailability, providing insights for potential application emerging bioactive nutraceuticals.

Language: Английский

Citations

2