Environmental Sciences Europe,
Journal Year:
2024,
Volume and Issue:
36(1)
Published: Jan. 10, 2024
Abstract
Background
Alzheimer's
disease
(AD)
and
other
forms
of
dementia
are
the
seventh
leading
cause
death.
Studies
discern
inclusion
air
pollution
among
modifiable
risk
factors
for
dementia,
while
limited
studies
China.
This
study
aims
to
examine
short-term
association
between
airborne
particulate
matter
(PM)
hospitalizations
AD,
including
economic
costs
in
Methods
A
total
4975
cases
AD
patients
hospitalized
from
2017
2019,
were
collected
nine
city
411
medical
institutions
Sichuan
Province,
Data
on
pollutants
such
as
PM
2.5
,
10
NO
2
obtained
183
quality
monitoring
stations
Province.
time
series-generalized
additive
model
was
used
estimate
exposure
(lag1–lag7
moving
average
lag01–lag07)
hospital
admissions
(HAs),
stratified
by
gender,
age,
season.
Results
Positive
found
HAs
AD.
The
greatest
effect
number
inpatients
single-day
lag1
(PM
:1.034
(95%
confidence
interval
(CI)
1.011,
1.058)).
also
significant
two-pollutant
model.
In
period,
16.48%
attributed
PM.
attributable
US$
2.56
million,
2.25
million
direct
0.31
indirect
costs.
Conclusions
suggests
that
may
increase
Province
result
associated
Journal of Gerontological Social Work,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 21
Published: March 5, 2025
This
study
examined
the
associations
between
childhood
threats
(parental
abuse
and
bullying
victimization)
cognitive
difficulties
in
mid
later
life.
Data
were
extracted
from
2022
Panel
Study
on
Active
Ageing
Society
Hong
Kong
(N
=
5,007).
Mediation
analyses
performed
using
PROCESS
macro,
both
for
entire
sample
gender-stratified
models.
Findings
revealed
that
frequent
parental
victimization
during
associated
with
increased
Contemporary
family
functioning
mediated
these
relationships.
Gender
differences
observed
mediating
role
of
functioning,
its
significance
limited
to
older
women.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: April 18, 2025
This
study
aims
to
analyze
temporal
trends
in
the
prevalence
and
disability-adjusted
life
year
(DALY)
burden
of
early-onset
dementia
(EOD)
globally
from
1990
2021
assess
attributable
burdens
modifiable
risk
factors.
Data
Global
Burden
Disease
Study
(GBD)
were
used.
EOD
was
defined
as
individuals
aged
40-64.
The
analysis
included
case
numbers,
age-standardized
rates
(ASPRs),
DALY
(ASDRs)
with
95%
confidence
intervals
(CIs),
stratified
by
global,
regional,
national
levels,
sociodemographic
index
(SDI),
sex.
Joinpoint
regression
evaluated
average
annual
percent
change
(AAPC).
Population
fractions
(PAFs)
estimated
proportion
DALYs
global
number
cases
nearly
doubled
2021,
reaching
7.758
million
(95%
CI
5.827-10.081)
3.774
1.696-8.881)
2021.
ASPR
ASDR
increased
slightly
355.9
267.2-462.8)
173.3
77.9-407.7)
per
100,000
In
highest
high-middle
SDI
countries
at
387.6
291.1-506.8),
while
middle
182.9
82.2-431).
fastest
increase
low
low-middle
2010
AAPCs
0.42%
0.34-0.50)
0.36%
0.33-0.39),
respectively.
A
significant
negative
correlation
found
between
ASDR.
During
COVID-19
pandemic
(2019-2021),
high-SDI
declined,
other
regions
saw
an
accelerated
increase.
high
fasting
plasma
glucose
(FPG)
most
factor
for
EOD-related
globally,
PAFs
body
mass
FPG
increasing
all
since
1990,
PAF
smoking
decreased.
countries,
particularly
rising
during
pandemic.
growing
influence
metabolic
factors
underscores
need
targeted
public
health
policies
resource
allocation
mitigate
burden.
Biomolecules,
Journal Year:
2022,
Volume and Issue:
12(8), P. 1136 - 1136
Published: Aug. 18, 2022
The
blood–brain
barrier
(BBB)
is
an
essential
structure
for
the
maintenance
of
brain
homeostasis.
Alterations
to
BBB
are
linked
with
a
myriad
pathological
conditions
and
play
significant
role
in
onset
evolution
neurodegenerative
diseases,
including
Alzheimer’s
disease.
Thus,
deeper
understanding
BBB’s
function
mandatory
better
knowledge
disorders
development
effective
therapies.
Because
studying
vivo
imposes
overwhelming
difficulties,
vitro
approach
remains
main
possible
way
research.
With
many
models
having
been
developed
over
last
years,
aim
this
review
systematically
present
most
relevant
designs
used
neurological
In
first
part
article,
physiological
structural–functional
parameters
human
detailed.
Subsequently,
available
presented
comparative
approach,
highlighting
their
advantages
limitations.
Finally,
new
perspectives
related
study
disease
help
novel
devices
that
mimic
milieu
gives
paper
originality.
Journal of Alzheimer s Disease Reports,
Journal Year:
2023,
Volume and Issue:
7(1), P. 659 - 674
Published: May 16, 2023
Background:
Diagnostic
pathways
for
patients
presenting
with
cognitive
complaints
may
vary
across
geographies.
Objective:
To
describe
diagnostic
of
6
countries.
Methods:
This
real-world,
cross-sectional
study
analyzed
chart-extracted
data
from
healthcare
providers
(HCPs)
6,744
China,
France,
Germany,
Spain,
UK,
and
the
US.
Results:
Most
common
symptoms
at
presentation
were
(memory/amnestic;
89.86%),
followed
by
physical/behavioral
(87.13%).
Clinical/cognitive
tests
used
in
>
95%,
Mini-Mental
State
Examination
being
most
test
(79.0%).
Blood
APOE
ɛ4/other
mutations,
or
to
rule
out
treatable
causes,
half
patients.
Clinical
higher
frequency
earlier
visits,
amyloid
PET/CSF
biomarker
testing
later
visits.
The
latter
ordered
low
rates
even
specialists
(across
countries,
5.7%
28.7%
PET
5.0%
27.3%
CSF
testing).
Approximately
received
a
diagnosis
(52.1%
which
Alzheimer’s
disease
[AD]).
Factors
that
influenced
risk
not
receiving
HCP
type
(higher
primary
care
physicians
versus
specialists)
region
(highest
China
Germany).
Conclusion:
These
highlight
variability
AD
countries
provider
types.
About
45%
are
referred/told
‘watch
wait’.
Improvements
can
be
made
use
testing.
Efforts
should
focus
on
further
defining
biomarkers
those
AD,
dismantling
barriers
such
capacity
reimbursement
challenges.
Environmental Sciences Europe,
Journal Year:
2024,
Volume and Issue:
36(1)
Published: Jan. 10, 2024
Abstract
Background
Alzheimer's
disease
(AD)
and
other
forms
of
dementia
are
the
seventh
leading
cause
death.
Studies
discern
inclusion
air
pollution
among
modifiable
risk
factors
for
dementia,
while
limited
studies
China.
This
study
aims
to
examine
short-term
association
between
airborne
particulate
matter
(PM)
hospitalizations
AD,
including
economic
costs
in
Methods
A
total
4975
cases
AD
patients
hospitalized
from
2017
2019,
were
collected
nine
city
411
medical
institutions
Sichuan
Province,
Data
on
pollutants
such
as
PM
2.5
,
10
NO
2
obtained
183
quality
monitoring
stations
Province.
time
series-generalized
additive
model
was
used
estimate
exposure
(lag1–lag7
moving
average
lag01–lag07)
hospital
admissions
(HAs),
stratified
by
gender,
age,
season.
Results
Positive
found
HAs
AD.
The
greatest
effect
number
inpatients
single-day
lag1
(PM
:1.034
(95%
confidence
interval
(CI)
1.011,
1.058)).
also
significant
two-pollutant
model.
In
period,
16.48%
attributed
PM.
attributable
US$
2.56
million,
2.25
million
direct
0.31
indirect
costs.
Conclusions
suggests
that
may
increase
Province
result
associated
