Epidemic Outbreak of Respiratory Syncytial Virus Infection After the end of the Zero‐COVID‐19 Policy in China: Molecular Characterization and Disease Severity Associated With a Novel RSV‐B Clade

Journal of Medical Virology, Journal Year: 2025, Volume and Issue: 97(4)

Published: April 1, 2025

ABSTRACT The resurgence of respiratory syncytial virus (RSV) has become a major concern recently. This study aimed to describe the temporal dynamics, genotype variability and disease severity RSV infection after end Zero‐COVID‐19 policy in Beijing, China. A total 905 patients were positive for at National Center Respiratory Medicine Beijing from November 2019 April 2024. Of these, 238 samples different successfully sequenced, 96 which identified as RSV‐A 142 RSV‐B. Phylogenetic analyses performed investigate genetic diversity. first surge was quite intense occurred out season, mainly affecting children. subsequent outbreak had significant impact among adults. cases caused by various clades new clade B.D.E.1 main cause epidemic Pneumonia immunocompromised hosts more common compared other clades. Accumulation substitutions could confer fitness advantage vivo. However, there no statistical difference clinical outcomes between infected those addressed timing trends infections, focusing on outbreaks, molecular characterization, associated with novel B.D.E.1. effective prevention strategy infections childhood, immunosuppressed adults elderly might be warranted.

Language: Английский

Respiratory Syncytial Virus Risk Profile in Hospitalized Infants and Comparison with Influenza and COVID-19 Controls in Valladolid, Spain, 2010–2022

Infectious Diseases and Therapy, Journal Year: 2024, Volume and Issue: 13(11), P. 2395 - 2413

Published: Oct. 12, 2024

We aimed to describe the risk profile of RSV infections among children aged ≤ 24 months in Valladolid from January 2010 August 2022 and compare them with influenza COVID-19 controls.

Language: Английский