Perceived benefits, information, vaccination history, and conspiracy beliefs as significant determinants of RSV vaccine acceptance among Arab seniors

Therapeutic Advances in Vaccines and Immunotherapy, Journal Year: 2025, Volume and Issue: 13

Published: Jan. 1, 2025

Background: Respiratory syncytial virus (RSV) poses a significant respiratory health risk to senior citizens, contributing substantially hospitalizations and mortality. With the recent approval of three RSV vaccines for elderly, it is critical understand factors that can shape vaccination attitudes inform public strategies enhance uptake among this vulnerable population. Objectives: This study aimed investigate potential could influence toward citizens in Arab countries. Design: A multinational cross-sectional study, adhering STROBE guidelines, was conducted using survey instrument previously validated through exploratory factor analysis assess newly approved vaccine. Methods: self-administered online distributed conveniently mainly across five The collected data on demographics, history, key constructs related vaccine attitude, including “Fear,” “Information,” “Accessibility,” “Benefits,” “Conspiracy.” Results: total 483 participants were included with majority from countries: Jordan ( n = 239, 49.5%), Kuwait 74, 15.3%), Egypt 68, 14.1%), Saudi Arabia 51, 10.6%), UAE 23, 4.8%), alongside other nations 28, 5.8%). Among respondents, 51.1% 247) expressed acceptance vaccine, 22.4% 108) hesitant, 26.5% 128) exhibited refusal. Multivariate identified perceived benefits (β 0.484, p < 0.001), information needs 0.229, previous history 0.087, 0.016) as positive predictors acceptance. Conversely, stronger conspiracy beliefs −0.083, 0.035) associated resistance. Fear accessibility not attitudes. Conclusion: findings showed benefits, access reliable information, are essential promote seniors. These recommended improve

Language: Английский

The MAPK Response to Virus Infection Is Modified by Probenecid

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(4), P. 246 - 246

Published: April 2, 2025

Respiratory viruses such as respiratory syncytial virus (RSV) annually cause illness, which may result in substantial disease and mortality susceptible individuals. Viruses exploit host cell machinery for replication, engages the mitogen-activated protein kinases (MAPK) pathway. The MAPK signaling pathways are triggered by pattern recognition receptors that recognize pathogen, infection, or external stimuli, leading to induction regulation of immunity inflammation. Probenecid, used improve renal function inhibiting tubular reabsorption uric acid, has been shown have therapeutic efficacy reducing inflammation blocking viral replication components pathway preclude replication. This review summarizes key molecular cascades response recognition, how this can be altered probenecid treatment.

Language: Английский