Therapeutic approach to fibromyalgia: a consensus statement on pharmacological and non-pharmacological treatment from the neuropathic pain special interest group of the Italian neurological society

Neurological Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 21, 2025

Abstract Background Although fibromyalgia is a disabling disease, there no targeted therapy for specific neurotransmitters or inflammatory mediators. Our aim was to provide neurologists with practical guidance the management of these difficult patients based on critical, narrative and non-systematic review randomized controlled trials (RCTs) from last 10 years. Methods The members Special Interest Group Neuropathic Pain Italian Neurological Society evaluated years answered questions that allow consensus main pharmacological non-pharmacological approaches. Results neuropathic pain working group agreed prescribing antiepileptic drugs antidepressants in case comorbidities anxiety depression. As second choice, experts have association antiepileptics antidepressants, while they disagree use opioids. Medical cannabis nutraceuticals are promising new treatment options, although more data needed prove their efficacy. suggesting physical activity at first visit, particularly aerobic strength training. considered cognitive behavioral approach be useful. Conclusions Pharmacologic co-occurring depression, as well an early nonpharmacologic primarily activity, may useful indication contemporary neurology clinical practice. Non-pharmacological such non-invasive brain stimulation NIBS, could improve evidence efficacy lead relevant improvement FM-related disability.

Language: Английский

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Fibromyalgia and Inflammation: Unrevealing the Connection

Cells, Journal Year: 2025, Volume and Issue: 14(4), P. 271 - 271

Published: Feb. 13, 2025

Fibromyalgia represents a chronic pain pathology characterized by severe musculoskeletal pain, fatigue, disturbances in sleep, and cognitive issues. Despite its presence, the underlying mechanisms of fibromyalgia remain inadequately understood; however, recent investigations have suggested that inflammation could play fundamental role pathophysiology this condition. Several studies highlight elevated concentrations pro-inflammatory cytokines, dysregulation immune responses, neuroinflammation patients. Furthermore, low-grade has been proposed as potential catalyst for sensitization pathways, which exacerbates symptoms fibromyalgia. Understanding disease might open new avenues therapeutic interventions while providing more profound insight into complex nature debilitating disorder. Although progress made, further research is needed to uncover complexities involved. This review investigates intricate relationship between fibromyalgia, analyzing evidence supports involvement both peripheral central inflammatory processes onset persistence

Language: Английский

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Neuroinflammatory and Immunological Aspects of Fibromyalgia

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(2), P. 206 - 206

Published: Feb. 17, 2025

Fibromyalgia is a common, high-impact condition of chronic widespread pain and sensory dysfunction associated with altered central peripheral processing. A growing body evidence supports the role neuroinflammation immune changes in fibromyalgia, narrative review this literature was undertaken. Published data suggest that interactions between neural networks system fibromyalgia appear to be bidirectional operate both centrally peripherally. There focus on processes occurring dorsal root ganglia maladaptive microglial cell activation. Ongoing insight into neuroinflammatory mechanisms opens potential avenues for development mechanism-based therapies what is, at present, challenging-to-manage condition.

Language: Английский

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Healthy Diet Consumption Among Chronic Pain Populations: A Concept Analysis

Pain Management Nursing, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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The Intersection of Sarcopenia and Musculoskeletal Pain: Addressing Interconnected Challenges in Aging Care

International Journal of Environmental Research and Public Health, Journal Year: 2025, Volume and Issue: 22(4), P. 547 - 547

Published: April 2, 2025

The global aging population faces a growing prevalence of sarcopenia and musculoskeletal (MSK) pain, two interrelated conditions that diminish physical function, quality life, independence in older adults. Sarcopenia, characterized by the loss muscle strength, mass, often coexists with MSK emerging evidence suggesting each condition may contribute to progression other. This perspective explores bidirectional relationship between highlighting shared mechanisms, including inactivity, cellular aging, chronic inflammation, gender-related hormonal changes, psychosocial factors such as depression social isolation, which underlie mutual exacerbation conditions. Through multidisciplinary framework, article emphasizes integrating care across specialties address these interconnected Practical approaches, comprehensive screening protocols, tailored resistance exercise, nutritional support, are discussed alongside innovative hybrid models combining in-person telemedicine systems enhance accessibility continuity care. A call action is presented for clinicians, policymakers, researchers adopt collaborative strategies, prioritize investment integrated healthcare, bridge critical knowledge gaps. By reframing delivery advancing efforts, this aims effectively complex challenges posed intersection pain

Language: Английский

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Symptom management and lifestyle interventions for people with fibromyalgia

Advanced Exercise and Health Science, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

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Gastrointestinal Conditions Affect Chronic Pain and Quality of Life in Women

International Journal of Environmental Research and Public Health, Journal Year: 2024, Volume and Issue: 21(11), P. 1435 - 1435

Published: Oct. 29, 2024

Pain is a chronic condition in many women; drugs used for its treatment are often accompanied by detrimental effects on organs, including the gut. Once inflamed, gut can affect pain processes. The aim of this study was to evaluate general health women suffering pain, with particular attention gastrointestinal (GI) conditions. possibility improve and quality life through personalized nutritional advice also tested. Forty from were contacted administration questionnaires define their features Their psychological, clinical reproductive states recorded. scores correlated GI, psychological scores. Diet suggestions given, evaluation repeated after 4 weeks. Thirty-eight included study: 32 suffered widespread had 6 pelvic pain. been present all years; more than 80% reported various types disorders related worse intolerant milk dairy products. GI score positively score. Dietary Inflammatory Index very high subjects. Personalized followed 26 subjects weeks resulted significant improvement parameters. We describe as being particularly affected alterations. change feeding habits beneficial effect other

Language: Английский

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ДИЕТА ПРИ ФИБРОМИАЛГИИ

University therapeutic journal, Journal Year: 2024, Volume and Issue: 6(4), P. 100 - 122

Published: Dec. 11, 2024

Многие пациенты с ревматическими заболеваниями считают, что диета влияет на их симптомы и, обращаясь прием ревматолога, рассчитывают получить подробные рекомендации по коррекции питания. При этом практикующие врачи далеко не всегда располагают достоверными данными о роли питания в возникновении и течении различных ревматических заболеваний. Рекомендации диете при ревматоидном артрите, остеоартрите особенно, подагре представлены отечественной научной литературе достаточно хорошо, тогда как вопросы фибромиалгии русскоязычной печати практически обсуждаются. В настоящей статье представлен обзор современных публикаций, преимущественно англоязычных, посвященных диетотерапии фибромиалгии. Обобщен опыт применения вегетарианских диет, том числе веганской сыроедческой диеты, лечебного голодания, исключения глутамата натрия аспартама из рациона питания, средиземноморской, аюрведической, безглютеновой, гипоаллергенной гипокалорийных кетогенной противовоспалительной диеты низким содержанием короткоцепочечных углеводов полиолов, а также пробиотиков, хорасанской пшеницы красного вина лечении Many patients with rheumatic diseases believe that diet affects their symptoms and, when contacting a rheumatologist, expect to receive detailed recommendations on nutrition correction. At the same time, practitioners do not always have reliable data role of in occurrence and course various diseases. Dietary for rheumatoid arthritis, osteoarthritis especially, gout are presented quite well Russian scientific literature, whereas issues fibromyalgia practically discussed Russian-language press. This article presents an overview modern publications, mainly English, devoted dietary therapy fibromyalgia. The experience using vegetarian diets, including vegan raw food diet, therapeutic fasting, exclusion sodium glutamate aspartame from Mediterranean, Ayurvedic, gluten-free, hypoallergenic hypocaloric ketogenic anti-inflammatory diets low short-chain carbohydrates polyols, as use probiotics, Khorasan wheat red wine treatment is summarized.

Language: Русский

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