Optical coherence tomography angiography of the retina and choroid in systemic diseases

Progress in Retinal and Eye Research, Journal Year: 2024, Volume and Issue: 103, P. 101292 - 101292

Published: Aug. 30, 2024

Optical coherence tomography angiography (OCTA) has transformed ocular vascular imaging, revealing microvascular changes linked to various systemic diseases. This review explores its applications in diabetes, hypertension, cardiovascular diseases, and neurodegenerative While OCTA provides a valuable window into the body's microvasculature, interpreting findings can be complex. Additionally, challenges exist due relative non-specificity of where observed might not unique specific disease, variations between machines, lack standardized normative database for comparison, potential image artifacts. Despite these limitations, holds immense future. The highlights promising advancements like quantitative analysis images, integration artificial intelligence faster more accurate interpretation, multi-modal imaging combining with other techniques comprehensive characterization vasculature. Furthermore, OCTA's future role personalized medicine, enabling tailored treatment plans based on individual findings, community screening programs early disease detection, longitudinal studies tracking progression over time is also discussed. In conclusion, presents significant opportunity improve our understanding management Addressing current limitations pursuing exciting directions solidify as an indispensable tool diagnosis, monitoring progression, potentially guiding decisions across health conditions.

Language: Английский

Observation of choroidal and retinal changes in acute leukemia in remission using ultra-widefield optical coherence tomography angiography

Photodiagnosis and Photodynamic Therapy, Journal Year: 2025, Volume and Issue: unknown, P. 104588 - 104588

Published: April 1, 2025

To observe choroidal and retinal changes in patients with acute leukemia the remission stage using ultra-widefield swept-source optical coherence tomography angiography (SS-OCTA). This cross-sectional study included 10 (10 eyes) 12 age-matched healthy controls (12 eyes). Demographic data, disease duration, laboratory parameters were recorded. SS-OCTA was used to scan × mm macular area. The retina choroid divided into five concentric circles diameters of 0-1 mm, 1-3 3-6 6-9 9-12 mm. OCTA parameters, including thicknesses choroid, vessel densities superficial vascular complexes (SVC) deep (DVC), three-dimensional vascularity volume (3D-CVV), index (3D-CVI), flow area choriocapillaries (CC), compared. thickness thinner than that control (P = 0.046) 0.036) ranges. 3D-CVV significantly smaller 0.024), 0.036), 0.038), 0.028) There no statistical differences terms thickness, SVC, DVC, 3D-CVI, CC between groups across all ranges (all P > 0.05). Thinning a reduction could be observed SS-OCTA.

Language: Английский

Bilateral optic nerve infiltration and leukemic retinopathy as initial signs of leukemia relapse with central nervous system involvement in an adult: a case report

BMC Ophthalmology, Journal Year: 2024, Volume and Issue: 24(1)

Published: May 28, 2024

Abstract Background We describe a case in which bilateral optic nerve infiltration and leukemic retinopathy were the initial signs of disease relapse patient with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph + -ALL) central nervous system (CNS) involvement. Case presentation A 65-year-old Asian female Ph -ALL complete remission presented at our institution symptoms visual disturbance, scotoma pain eye movement both eyes for 1-month duration. Ophthalmic examination revealed remarkable disc swelling multiple flame-shaped peripapillary hemorrhages, retinal venous dilation hemorrhages eyes. She was subsequently referred to treating oncologist diagnosed relapsed diseases involving bone marrow CNS. After intrathecal (IT) therapy, her acuity dramatically improved, infiltrates decreased. Conclusions To best knowledge, this is first report ALL CNS involvement presenting as an adult. Hence, we highlight priority sensitivity ophthalmic examinations, they are noninvasive methods detecting relapse.

Language: Английский