Protective effects of docosahexaenoic acid combined with bilberry extract on myopic Guinea pigs DOI Creative Commons

Tainan Lin,

Jianzhang Hu, Qian Wen

et al.

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Dec. 17, 2024

This study aims to investigate the protective effects of docosahexaenoic acid (DHA) combined with bilberry extract (BE) on myopic guinea pigs. In total, 105 healthy pigmented pigs aged 2 weeks were selected and randomly divided into five groups. The normal control (NC) group received no treatment, while experimental groups wore -6.0D lenses right eye establish an animal model lens-induced myopia (LIM). These further based different treatments: feeding, DHA BE + treatment. Refractive error axial length for both eyes measured before modeling, after 4 8 Fundus examination was performed, choroidal thickness, vascularity index (CVI), maximal mixed response in dark adaptation (Max-ERG), cone cell light (Cone-ERG) measured. After we observed a significant reduction refractive shortening length, improvement fundus condition, increased thickness CVI LIM group. Electroretinogram (ERG) showed that amplitudes a-wave b-wave enhanced Max-ERG Cone-ERG tests. exhibited superior compared combination delayed progression more effective than or alone. synergistic effect offers new approach prevention treatment myopia.

Language: Английский

Recent Advances in Ophthalmic Interventions: Exploring Innovations in Myopia, Cataract Surgery, and Visual Function DOI Open Access
Kazuno Negishi

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(1), P. 195 - 195

Published: Jan. 1, 2025

As our understanding of ophthalmic optics and visual function advances, the intersection between clinical practice technological innovation becomes increasingly significant in enhancing patient outcomes [...]

Language: Английский

Citations

0

Key strategies to reduce the global burden of myopia: consensus from the international myopia summit DOI Creative Commons
Leila Sara Eppenberger,

Amanda Davis,

Serge Resnikoff

et al.

British Journal of Ophthalmology, Journal Year: 2025, Volume and Issue: unknown, P. bjo - 326643

Published: Feb. 19, 2025

In this paper, we describe key strategies to guide global collaborative efforts further reduce the burden of myopia and myopia-related visual impairment. A modified Delphi method was applied as an iterative multistage process collect expert stakeholders’ opinions extract consensus regarding diagnosis, prevention control. Anonymous pre-meeting preparation rounds, structured discussions for prioritisation development areas were performed. Consensus reached on three collaborate complement existing frameworks: (1) Myopia defined not only a refractive error but also disease with phenotypic features allowing risk stratification significant (2) addition preventive strategies, focus is needed preventing progression high (HM). (3) treating pathologic (PM), that is, end-stage irreversible conclusion, workgroup suggests global, strategy across public health, healthcare advocacy sectors support in reducing impairment from myopia. Complementary health efforts, additional defining emphasis associated HM PM should be considered.

Language: Английский

Citations

0

Effectiveness of Low-Level Red Light in Controlling Myopia Progression in Children: A Systematic Review and Meta-Analysis DOI Open Access

Yazeed Bader Alaql,

Saleh A Alkhalaf,

Bader A Almuqaythil

et al.

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

This study aimed to evaluate the effectiveness of low-level red light (LLRL) therapy compared single-vision spectacles (SVS) in controlling myopia progression, focusing on spherical equivalent refraction (SER), axial length (AL), and subfoveal choroidal thickness (SFCT). A comprehensive search was conducted across PubMed, Cochrane Library, ScienceDirect, Web Science, including only randomized controlled trials (RCTs) involving myopic patients aged 16 years or younger. Mean differences were calculated with 95% CIs, I² statistic used assess heterogeneity among studies. The meta-analysis included 11 RCTs. At three months, significant observed between LLRL SVS SER (estimate: 0.225; CI: 0.042, 0.408; p = 0.016) AL -0.137; -0.280, 0.007; 0.062). six noted 0.450; 0.351, 0.550; < 0.001), -0.179; -0.278, -0.079; SFCT 35.281; 23.230, 47.331; 0.001). By 12 remained for 0.806; 0.675, 0.937; 0.001) -0.294; -0.416, -0.172; These findings suggest that effectively reduces progression children, as indicated by improvements SER, slower growth, stabilization slight increases SFCT. However, further studies are necessary determine optimal dosage, long-term safety, overall efficacy therapy.

Language: Английский

Citations

0

Social behavioral analysis of the influence of residential area and grade on pupils’ myopia rate: a cross-sectional survey in Nanjing, China DOI Creative Commons

Yixin Xie,

Wen Bai,

Yunfan Zhou

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: March 19, 2025

Objective This study aims to examine the prevalence of myopia among pupils in different residential areas (city center, nearby suburbs, and far suburbs) grade levels (lower, middle, upper), analyzing social behaviors risk factors guide early intervention. Methods A cross-sectional survey was conducted with elementary students across various regions Nanjing. total 2,342 valid questionnaires were collected. Univariate multivariate logistic regression analyses used identify assess for their variations levels. Results The revealed an overall 35.65% (95% CI = 33.71–37.59) Nanjing, highest rate observed suburbs (41.34, 95% 38.37–44.31). Myopia increased level. Multivariate analysis identified 8 significant myopia, including visual fatigue, frequent eye rubbing, late bedtimes, heavy burdens, insufficient time spent outdoors, device breaks, mobile phone use, infrequent vision checks. Risk varied by region Common all groups included fatigue City center exhibited unique factors, such as bedtimes outdoors. Nearby displayed burdens entertainment-oriented electronic use. Far a factor prevalent use phones. Besides, lower showed notably higher while upper more likely have breaks. Conclusion Different behavioral play key role occurrence grades, targeted intervention measures need be developed based on regional characteristics level features.

Language: Английский

Citations

0

Clinical evaluation of MyoCare in Europe (CEME) for myopia management: One‐year results DOI Creative Commons
Cristina Álvarez-Peregrina, Miguel Ángel Sánchez‐Tena, César Villa Collar

et al.

Ophthalmic and Physiological Optics, Journal Year: 2025, Volume and Issue: unknown

Published: April 29, 2025

Abstract Aims To evaluate the efficacy of CARE spectacle lenses in slowing myopia progression among European children. Methods In a 2‐year randomised, parallel‐group, double‐masked, multicentre clinical trial, 234 children aged 6–13 years were enrolled. All participants myopic, with cycloplegic spherical equivalent refractive error (SE) between −0.75 D and −5.00 D, astigmatism ≤1.50 anisometropia ≤1.00 at least 0.50 previous year. The treatment group received MyoCare cylinder annular elements (CARE), control single‐vision (SVL). Axial length (AL) SE measured baseline, 6 12 months. Wearability questionnaires administered 1 week 3 Central peripheral visual acuity (VA) was recorded dispensing after Generalised linear models estimated changes AL, adjusting for lens type, age baseline measurements. Results After months, wearing showed less progression, difference AL (compared to SVL) −0.21 (CI: 0.10 0.32 D) 0.14 mm −0.17 −0.10 mm), respectively. VA did not decrease lenses. Peripheral decreased by 0.09 logMAR nasal temporal zones, Analysis fast progressors indicated that 39.7% SVL eyes progressed ≤−0.50 D/year compared 21.1% ( p < 0.01). For 56.0% had an elongation ≥0.20 21.3% Conclusions children, significantly slower year wear. Further monitoring will provide comprehensive evaluation long‐term efficacy.

Language: Английский

Citations

0

Effectiveness of Defocus Incorporated Multiple Segments in Slowing Myopia Progression in Pediatric Patients as a Function of the Age. Three Years Follow Up DOI Open Access
Luca Buzzonetti, Sergio Petroni, Matteo Federici

et al.

Published: Aug. 13, 2024

Background: To evaluate the effectiveness of Defocus Incorporated Multiple Segments (DIMS) in slowing myopia progression pediatric patients as a function age. Methods: This was non-randomized experimenter-masked retrospective controlled observational study European individuals aged 6 -16 years with progressive but no ocular pathology. We retrospectively reviewed charts participants allocated to receive DIMS spectacles (Hoya&reg; MiyoSmart&reg;) or single vision spectacle lenses (control group). Cycloplegic spherical equivalent (SE) and axial length (AL), were measured at baseline 36 month follow up. The results stratified by age into four groups: that wore oldest youngest than 10 (respectively, group A, 20 mean 13.6&plusmn;2.2 C, 9.0&plusmn;1.2) age-matched control groups (group B, 18 13.2&plusmn;2.5 D, 22 8.5&plusmn;0.9). Results: At months, SE AL increase resulted significantly reduced A respectively compared B D (p&lt;0.05). Linear regression analysis showed significant correlation (P&lt;0.05) between patient for only also AL. Groups did not show any (P&gt;0.05). Conclusion: seem slow patients, however their greatest children Morover our findings suggest may be more reliable parameter evaluating progression.

Language: Английский

Citations

1

Effectiveness of Defocus Incorporated Multiple Segments in Slowing Myopia Progression in Pediatric Patients as a Function of Age: Three-Year Follow-Up DOI Creative Commons
Luca Buzzonetti, Sergio Petroni, Matteo Federici

et al.

Diseases, Journal Year: 2024, Volume and Issue: 12(9), P. 222 - 222

Published: Sept. 18, 2024

Background: The purpose of this study is to evaluate the effectiveness Defocus Incorporated Multiple Segments (DIMSs) in slowing myopia progression pediatric patients as a function age. Methods: This was non-randomized experimenter-masked retrospective controlled observational European individuals aged 6–16 years with progressive but no ocular pathology. We retrospectively reviewed charts participants allocated receive DIMS spectacles (Hoya® MiyoSmart®) or single-vision spectacle lenses (control group). Cycloplegic spherical equivalent (SE) and axial length (AL) were measured at baseline 12-, 24-, 36-month follow-ups. results stratified by age into four groups: wearing older younger than 10 (group A, 20 mean 13.6 ± 2.2, group C, 9.0 1.2) age-matched control groups B, 18 13.2 2.5, D, 22 8.5 0.9). Results: At 36 months, SE AL increase significantly reduced A respectively, compared B D (p < 0.05). Linear regression analysis showed significant correlation 0.05) between patient for only AL. Groups did not show any > Conclusions: seem slow patients; however, their shows greatest children Moreover, our findings suggest that may be more reliable parameter evaluating progression.

Language: Английский

Citations

0

Government instituted public health policy for myopia control in schools—the overlooked variable in myopia prevention interventions? DOI
Ken K. Nischal

Eye, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 21, 2024

Language: Английский

Citations

0

Protective effects of docosahexaenoic acid combined with bilberry extract on myopic Guinea pigs DOI Creative Commons

Tainan Lin,

Jianzhang Hu, Qian Wen

et al.

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Dec. 17, 2024

This study aims to investigate the protective effects of docosahexaenoic acid (DHA) combined with bilberry extract (BE) on myopic guinea pigs. In total, 105 healthy pigmented pigs aged 2 weeks were selected and randomly divided into five groups. The normal control (NC) group received no treatment, while experimental groups wore -6.0D lenses right eye establish an animal model lens-induced myopia (LIM). These further based different treatments: feeding, DHA BE + treatment. Refractive error axial length for both eyes measured before modeling, after 4 8 Fundus examination was performed, choroidal thickness, vascularity index (CVI), maximal mixed response in dark adaptation (Max-ERG), cone cell light (Cone-ERG) measured. After we observed a significant reduction refractive shortening length, improvement fundus condition, increased thickness CVI LIM group. Electroretinogram (ERG) showed that amplitudes a-wave b-wave enhanced Max-ERG Cone-ERG tests. exhibited superior compared combination delayed progression more effective than or alone. synergistic effect offers new approach prevention treatment myopia.

Language: Английский

Citations

0