Aggregation-Induced Emission (AIE), Life and Health

ACS Nano, Journal Year: 2023, Volume and Issue: 17(15), P. 14347 - 14405

Published: July 24, 2023

Light has profoundly impacted modern medicine and healthcare, with numerous luminescent agents imaging techniques currently being used to assess health treat diseases. As an emerging concept in luminescence, aggregation-induced emission (AIE) shown great potential biological applications due its advantages terms of brightness, biocompatibility, photostability, positive correlation concentration. This review provides a comprehensive summary AIE luminogens applied structure dynamic physiological processes, disease diagnosis treatment, detection monitoring specific analytes, followed by representative works. Discussions on critical issues perspectives future directions are also included. aims stimulate the interest researchers from different fields, including chemistry, biology, materials science, medicine, etc., thus promoting development fields life health.

Language: Английский

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Rational Design of NIR-II AIEgens with Ultrahigh Quantum Yields for Photo- and Chemiluminescence Imaging

Journal of the American Chemical Society, Journal Year: 2022, Volume and Issue: 144(33), P. 15391 - 15402

Published: Aug. 10, 2022

Fluorescence imaging in the second near-infrared window (NIR-II, 1000–1700 nm) using small-molecule dyes has high potential for clinical use. However, many NIR-II suffer from emission quenching effect and extremely low quantum yields (QYs) practical usage forms. The AIE strategy been successfully utilized to develop with donor–acceptor (D–A) structures acceptable QYs aggregate state, but there is still large room QY improvement. Here, we rationally designed a emissive dye named TPE-BBT its derivative (TPEO-BBT) by changing electron-donating triphenylamine unit tetraphenylethylene (TPE). Their nanoparticles exhibited ultrahigh relative of 31.5% 23.9% water, respectively. By an integrating sphere, absolute was measured be 1.8% water. Its crystals showed 10.4%, which highest value among organic small molecules reported so far. optimized D–A interaction higher rigidity state are believed two key factors QY. Finally, photoluminescence (PL) chemiluminescence (CL) bioimaging through successive CL resonance energy transfer Förster processes. realized excellent PL quality mouse blood vessels local arthrosis inflammation mice signal-to-background ratio 130. Thus, design presented here brings new possibilities development bright technologies.

Language: Английский

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Research Progress of Intramolecular π‐Stacked Small Molecules for Device Applications

Advanced Materials, Journal Year: 2021, Volume and Issue: 34(22)

Published: Oct. 1, 2021

Abstract Organic semiconductors can be designed and constructed in π‐stacked structures instead of the conventional π‐conjugated structures. Through‐space interaction (TSI) occurs optoelectronic materials. Thus, unlike electronic coupling along conjugated chain, functional groups stack closely to facilitate spatial electron communication. Using motifs, chemists materials scientists find new ways for constructing with aggregation‐induced emission (AIE), thermally activated delayed fluorescence (TADF), circularly polarized luminescence (CPL), room‐temperature phosphorescence (RTP), as well enhanced molecular conductance. devices based on molecules have exhibited very promising performance, some them exceeding analogues. Recently, reports various organic grown rapidly, prompting this review. Representative scaffolds newly developed systems could stimulate more attention through‐space charge transfer well‐known through‐bond transfer. Finally, opportunities challenges utilizing improving particular are discussed. The previous achievements upcoming prospects may provide insights into theory, materials, field semiconductors.

Language: Английский

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Molecular Motion and Nonradiative Decay: Towards Efficient Photothermal and Photoacoustic Systems

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 61(30)

Published: May 11, 2022

Nonradiative decay invariably competes with radiative during the deexcitation process of matter. In community luminescence research, nonradiative has been deemed less attractive than decay. However, all things in their being are good for something and so is As molecular motion-facilitated (MMFND) effect inevitable photophysical processes, it provides a new avenue to convert harvested light energy into exploitable forms by harnessing motion. many cases, active motion enables thermal deactivation from excited states. this Minireview, recent advances photothermal photoacoustic systems MMFND character summarized. We believe that presentation rational engineering efficient generation will deepen understanding relationship between navigate people rethink positive aspects establishment light-controllable techniques.

Language: Английский

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How to Manipulate Through-Space Conjugation and Clusteroluminescence of Simple AIEgens with Isolated Phenyl Rings

Journal of the American Chemical Society, Journal Year: 2021, Volume and Issue: 143(25), P. 9565 - 9574

Published: June 11, 2021

Apart from the traditional through-bond conjugation (TBC), through-space (TSC) is gradually proved as another important interaction in photophysical processes, especially for recent observation of clusteroluminescence nonconjugated molecules. However, unlike TBC conjugated chromophores, it still challenging to manipulate TSC and clusteroluminescence. Herein, simple triphenylmethane (TPM) its derivatives with electron-donating electron-withdrawing groups were synthesized, their properties systematically studied. TPM was characterized visible due intramolecular TSC. Experimental theoretical results showed that introduction into could red-shift wavelength increase efficiency simultaneously, increased electronic density stabilization inefficient or even quenched caused by vigorous excited-state motion intermolecular photoinduced electron transfer process. This work provides a reliable strategy

Language: Английский

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Aliphatic Polyesters with White-Light Clusteroluminescence

Journal of the American Chemical Society, Journal Year: 2022, Volume and Issue: 144(33), P. 15286 - 15294

Published: July 7, 2022

Single-molecule white-light emission (SMWLE) has many advantages in practical applications; however, the fabrication of SMWLE from nonconjugated luminescent polymers, namely, clusteroluminogens (CLgens), is still a big challenge. Herein, first example linear polyesters with reported. Twenty-four kinds aliphatic tunable clusteroluminescence (CL) colors and efficiency were synthesized by copolymerization six epoxides four anhydrides. Experimental calculation results prove that, at primary structure level, balance structural flexibility rigidity via adjusting side-chain length significantly enhances CL without wavelength change. However, altering chemical structures monomer succinic anhydride to trans-maleic (MA), cis-MA, citraconic (CA), secondary these change helix straight folding sheet accompanied gradually red-shifted 460 570 nm due increase through-space n–π* interactions, as demonstrated computational experimental results. Then, pure CIE coordination (0.30, 0.32) based on overlapped short-wavelength long-wavelength achieved CA-based polyesters. This work not only provides further insights into mechanism but also new strategy manipulate properties regulating hierarchical CLgens.

Language: Английский

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Secondary through-space interactions facilitated single-molecule white-light emission from clusteroluminogens

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: June 17, 2022

Clusteroluminogens refer to some non-conjugated molecules that show visible light and unique electronic properties with through-space interactions due the formation of aggregates. Although mature systematic theories molecular photophysics have been developed study conventional conjugated chromophores, it is still challenging endow clusteroluminogens designed photophysical by manipulating interactions. Herein, three donor-acceptor structures different halide substituents are synthesized. These compounds multiple emissions even single-molecule white-light emission in crystalline state. The intensity ratio these easily manipulated changing atom excitation wavelength. Experimental theoretical results successfully disclose nature emissions: conjugation for short-wavelength fluorescence, charge transfer based on secondary long-wavelength room-temperature phosphorescence. introduction not only enriches their varieties but also inspires establishment novel aggregate clusteroluminescence.

Language: Английский

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Mitochondria-targeted smart AIEgens: Imaging and therapeutics

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 473, P. 214818 - 214818

Published: Sept. 21, 2022

Language: Английский

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Schiff Base Aggregation-Induced Emission Luminogens for Sensing Applications: A Review

ACS Sensors, Journal Year: 2022, Volume and Issue: 7(9), P. 2521 - 2536

Published: Sept. 1, 2022

Fluorescence sensing can not only identify a target substrate qualitatively but also achieve the purpose of quantitative detection through change fluorescence signal. It has advantages immense sensitivity, rapid response, and excellent selectivity. The proposed aggregation-induced emission (AIE) concept solves problem traditional fluorescent molecules becoming weak or quenched in high concentration aggregated state conditions. Schiff base probes have simple synthesis, low toxicity, easy design. They are often used for various substances. In this review we cover late developments compounds with AIE characteristics working as sensors.

Language: Английский

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Novel pyrene-based aggregation-induced emission luminogen (AIEgen) composite phase change fibers with satisfactory fluorescence anti-counterfeiting, temperature sensing, and high-temperature warning functions for solar-thermal energy storage

Advanced Composites and Hybrid Materials, Journal Year: 2023, Volume and Issue: 6(4)

Published: June 17, 2023

Language: Английский

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