Halogen‐Bearing Peptide Liquid Crystals to Elicit Molecular Alignments for Residual Dipolar Coupling Measurement

Macromolecular Rapid Communications, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Abstract Residual dipolar coupling (RDC) not only contributes to the dynamic analysis of proteins but also provides a robust route for structure determination small organic compounds. An essential prerequisite this methodology is availability alignment media. Herein, series novel peptide‐based media are generated by introducing D‐type or halogen‐bearing amino acids RDC measurements. Compared with self‐assembled peptide liquid crystal (LC) medium containing D ‐amino acid, incorporation halogen elements improved electronegativity LCs, resulting in enhanced strength toward analytes. Meanwhile, LCs can provide different orientations relative non‐halogenated media, allowing acquirement independent sets RDCs. The presented enrich existing ignite way creating multiple independent, non‐linearly related measurement.

Language: Английский

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Helical Polymer‐Containing Bottlebrush Polymers (BBPs): Design, Synthesis, and Perspectives

Macromolecular Rapid Communications, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

Abstract Helical polymer‐containing bottlebrush polymers (BBPs) are a special and fascinating type of polymer. They possess topology contain helical as main chains (MCs) or side (SCs), thereby presenting interesting fantastic properties, such chiral amplification, circularly polarized luminescence, photonic crystal, so on. This review mainly focuses on BBPs containing polypeptides, polyacetylenes (PAs), polyisocyanides (PIs). Detailed summarizations severally given to with polypeptides MCs SCs. Meanwhile, comprising PAs fully discussed. What's more, consisted PIs SCs described separately. In addition, other briefly introduced, too. The authors hope this will motivate more interest in developing complex topologies encourage further progress functional materials.

Language: Английский

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“Sergeants-and-soldiers” effect and modified Ising model in chiral polymer materials

Science China Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 8, 2025

Language: Английский

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Modulating the Curvature of Protein Self-Assembled Spiral Nanotubules

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: May 12, 2025

Structural transformations from ribbons to twisted helical are often observed across supramolecular assemblies and macroscopic structures can be described under a consistent theoretical framework. Conical molecular self-assembled structures, however, rarely observed, may require more than one subunit, their dimensions hard control, poorly understood. Cytoskeleton microtubule (MT) is dynamic protein-polymer that self-assembles αβ-tubulin heterodimer, providing mechanical support Eukaryotic cells. Colchicine drug known bind the exchangeable nucleotide site on β-tubulin subunit suppress MT assembly. The tetravalent polyamine spermine promotes assembly tubulin spiral including conical spirals, tubules of inverted tubules. Here we show how colchicine as single agent suppressed ring already at substoichiometric concentrations, whereas in presence spermine, tubulin-colchicine stoichiometry controlled curvature assemblies. At fixed concentration, concentration modulated radii nanotubular structures. nanotubules monotonically decreased with concentration. We attribute our observation increased dimer induced by colchicine.

Language: Английский

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Precise main-chain length dependence for the chiral supramolecular self-assembly of oligofluorenes in chiral solvent

European Polymer Journal, Journal Year: 2024, Volume and Issue: unknown, P. 113682 - 113682

Published: Dec. 1, 2024

Language: Английский

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