Molecular Targets of Plant-Derived Bioactive Compounds in Oral Squamous Cell Carcinoma DOI Open Access
Gabriela Mitea, Verginica Schröder, Irina Mihaela Iancu

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(21), P. 3612 - 3612

Published: Oct. 26, 2024

Background: With a significant increase in both incidence and mortality, oral cancer—particularly squamous cell carcinoma (OSCC)—is one of the main causes death developing countries. Even though there is evidence advances surgery, chemotherapy, radiotherapy, overall survival rate for patients with OSCC has improved, but by small percentage. This may be due, on hand, to fact that disease diagnosed when it at too-advanced stage, metastases are already present. Methods: review explores therapeutic potential natural herbal products their use as adjuvant therapies treatment cancer from online sources databases (PubMed, Web Science, Google Scholar, Research Gate, Scopus, Elsevier). Results: if classic known effective, they often produce many serious side effects can create resistance. Certain plant compounds offer complementary approach inducing apoptosis, suppressing tumor growth, improving chemotherapy effectiveness. The integration these conventional treatments obtain remarkable synergistic represents major point interest authors. highlights study molecular mechanisms efficiency vitro vivo models, well strategic ways which drugs administered optimize real contexts. Conclusions: have impact oncology community, creating new inspirations development more safer less toxic potential.

Language: Английский

Elucidating the role of lipid metabolism dysregulation in the transition from oral lichen planus to oral squamous cell carcinoma DOI Creative Commons

Manman Yao,

Ying-Chun Lu,

Tiejun Liu

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 16, 2025

Oral Lichen Planus (OLP) is a chronic inflammatory disorder that may progress to Squamous Cell Carcinoma (OSCC). Lipid metabolism dysregulation has been implicated in tumor development and immune response modulation. This study aims explore the role of lipid metabolism, particularly lipids diacylglycerol (DAG), triacylglycerol (TAG), phosphatidylcholine (PC), progression from OLP OSCC, identify potential therapeutic targets for prevention treatment. We performed Mendelian randomization (MR) analysis investigate causal relationships between risk OSCC. Differential gene expression was conducted key genes related metabolism. The interactions species were examined using drug databases (DrugBank, DGIdb, TCMSP) candidates. Enrichment signaling pathways, including PPAR signaling, also understand underlying mechanisms. Our MR revealed DAG exerts protective effect (OR < 1), but its shifts factor OSCC > potentially by altering microenvironment. TAG PI plays critical tumorigenesis. Gene identified several metabolism-related genes, SLC27A6, FABP3, FABP4, ADIPOQ, PLIN1, whose differed highlighting their importance progression. These enriched pathway, suggesting involvement growth Potential candidates, such as palm acid (PA), Imatinib, Curcumin, through drug-repurposing strategies. crucial Targeting pathways DAG, TAG, PI, offer promising strategies early diagnosis intervention. provides novel insights into molecular mechanisms OLP-to-OSCC suggests natural compounds, future clinical applications. Further research needed validate these findings settings. Not applicable.

Language: Английский

Citations

0
Consider topical superpotent corticosteroids for oral lichen planus; reserve systemic therapy for severe disease DOI

Esther Kim,

Simon Fung

Drugs & Therapy Perspectives, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Language: Английский

Citations

0
Impact of oral precancerous lesions on oral cancer development in patients with oral lichen planus: a retrospective cohort study of 318 oral lichen planus patients DOI Creative Commons
Yu-Cheng Chu,

Pei-Yu Lin,

Wan‐Ting Huang

et al.

Frontiers in Oral Health, Journal Year: 2025, Volume and Issue: 6

Published: March 6, 2025

Oral lichen planus (OLP) has been implicated as a potential risk factor for oral cancer. This study aimed to investigate the long-term determinants of cancer development following diagnosis OLP. A retrospective cohort 318 patients with histopathologically confirmed OLP was conducted at tertiary medical center from 1995 2018. Patients were categorized into two groups based on presence or absence precancerous lesions (OPLs). Baseline characteristics, underlying conditions, and lifestyle factors compared between groups. The hazard ratio (HR) 10-year cumulative estimated using logistic regression Kaplan-Meier analysis, respectively. In our cohort, total 33 (10.38%) diagnosed After adjusting confounders, OPLs (HR, 2.98), age over 50 years 4.36), chronic kidney disease 4.46), alcohol consumption 4.23) emerged independent in (P < 0.05). current indicates that OPLs, including histologically verrucous hyperplasia varying degrees dysplasia, is associated an increased Further research needed elucidate molecular mechanisms linking OLP, OPL, occurrence.

Language: Английский

Citations

0
Thyroid Dysfunction and Oral Lichen Planus: Evidence From Two-Sample Mendelian Randomization Analysis DOI

Pengxian Xie,

Wei Peng

International Dental Journal, Journal Year: 2025, Volume and Issue: 75(3), P. 1621 - 1631

Published: March 26, 2025

Language: Английский

Citations

0
Dental Implant Therapy in Patients With Autoimmune Diseases: A Scoping Review DOI Creative Commons
Emil Hyldahl, Henning Schliephake, Simon Storgård Jensen

et al.

Clinical Oral Implants Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

ABSTRACT Objectives The aim of this scoping review is to determine the effects autoimmune diseases (ADs) and agents used for treatment on dental implant survival biologic outcomes. Material Methods An electronic database search was performed in MEDLINE (PubMed), Cochrane Library, Embase 29‐04‐2024. Clinical studies English therapy patients with ADs were potentially eligible. Recorded variables included study information, patient demographics, ADs, immunosuppressants, antiresorptives, rate, complications, oral health‐related quality life. Descriptive statistics performed. Results A total 6319 records retrieved through hand search, which 87 could be an overweight case reports retrospective studies. available evidence characterized by a high number placed low hierarchy evidence. Several outcome parameters heterogeneously reported. Glucocorticoids most frequently administrated immunosuppressant. rate overall 85.3%–100%; hereof, 46.7%–100% losses occurred early, indicating certain risk failure. Despite lichen planus (OLP) patients, one lost 42 55 implants untreated flare‐up OLP. Conclusions Dental generally predictable after mid‐term follow‐up, whom many receive immunosuppressants. Implant predominantly before prosthetic loading. Particularly, mucosal manifestations their seem benefit from implant‐supported restorations provided lesions are well treated. However, low‐level scientific available.

Language: Английский

Citations

0
Probiotics and prebiotics: new treatment strategies for oral potentially malignant disorders and gastrointestinal precancerous lesions DOI Creative Commons

Zhuwei Huang,

Julia Zhu,

Xiaobo Bu

et al.

npj Biofilms and Microbiomes, Journal Year: 2025, Volume and Issue: 11(1)

Published: April 8, 2025

Oral potentially malignant disorders (OPMDs) and gastrointestinal precancerous lesions (GPLs) are major public health concerns because of their potential to progress cancer. Probiotics, prebiotics, engineered probiotics can positively influence the prevention management OPMDs GPLs. This review aims comprehensively application status probiotics, prebiotics in GPLs, explore mechanisms action, anticipate future clinical use.

Language: Английский

Citations

0
Italian Consensus on the treatment of oral lichen planus DOI
Élisa Cinotti, Martina D’Onghia, Laura Calabrese

et al.

Italian Journal of Dermatology and Venereology, Journal Year: 2025, Volume and Issue: 160(2)

Published: April 1, 2025

Oral lichen planus (OLP) is a chronic inflammatory condition of uncertain etiology affecting oral mucosae by T-cell mediated inflammation. It affects between 1% and 3% the global population, predominantly middle-aged adults (50-60 years), with higher incidence in women. The immune response thought to target keratinocytes, leading cell death, particularly through CD8+ T lymphocytes. OLP manifests various clinical forms, such as reticular, papular, erosive, atrophic, reticular subtype being most common. Erosive severe, characterized widespread erosions, while atrophic often follows erosive stages, tongue depapillated surface. Currently, no curative treatment exists for OLP, management focuses on symptom relief, including reducing pain discomfort. Thus, multidisciplinary approach involving dermatologists, surgeons, dentists required. For this reason, scientific community represented Italy Mucosal Diseases Study Group SIDeMaST (Italian Society Dermatology Venereology) reports its experience providing recommendations dermatologists based latest evidence optimize OLP.

Language: Английский

Citations

0
Diagnostic Infrared Thermography of the Tongue and Taste Perception in Patients with Oral Lichen Planus: Case-Control Study DOI Open Access
Elena Nicolas-Rodriguez, Eduardo Pons-Fuster, Pía López‐Jornet

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(2), P. 435 - 435

Published: Jan. 12, 2024

Oral lichen planus (OLP) is a chronic inflammatory disease of autoimmune origin that affects the skin and mucous membranes. The aim this study was to assess effectiveness infrared thermography (IRT) as diagnostic tool in patients with oral (OLP), well disturbances taste perception, cases without tongue involvement. A case-control carried out sample 87 divided into three groups: healthy individuals (controls;

Language: Английский

Citations

3
Relationship between Oral Lichen Planus and Cardiovascular Disease of Atherosclerotic Origin: Systematic Review and Meta-Analysis DOI Open Access

Beatriz González Navarro,

Sonia Egido-Moreno,

Carlos Omaña Cepeda

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(16), P. 4630 - 4630

Published: Aug. 7, 2024

Background/Objectives: Oral lichen planus (OLP) is a chronic inflammatory autoimmune disease of the oral mucosa that affects between 0.5% and 2% general population. In last decade, several studies have associated cardiovascular diseases (CVDs) with some skin such as planus, demonstrating presence dyslipidemia in these pathologies. The objective this work to review whether patients OLP show higher CRP levels compared healthy control population without OLP. Methods: Searches were carried out Medline, Scopus, Cochrane. had perform histopathological diagnosis for could not take any medication treat disorder. Non-lichenoid reactions included. Results: After an initial search provided us 254 papers, number was reduced 10 articles after detailed evaluation. All them case–control analytical risk factors affected by subjects. Conclusions: There no scientific evidence possible association CVDs. only we can prove one OPL CVD factors, especially those related lipid profile. More are needed order evaluate relationship diagnosed

Language: Английский

Citations

3
Association Between Autoimmune Thyroid disease and Oral Lichen Planus: A Multi-Omic Genetic Analysis DOI Creative Commons
Jie Ni, Xinjian Ye, Yitong Chen

et al.

International Dental Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

Citations

2