Digital Endpoints: Definition, Benefits, and Current Barriers in Accelerating Development and Adoption DOI Creative Commons

Matthew Landers,

Ray Dorsey,

Suchi Saria

et al.

Digital Biomarkers, Journal Year: 2021, Volume and Issue: 5(3), P. 216 - 223

Published: Sept. 13, 2021

The assessment of health and disease requires a set criteria to define status progression. These measures are referred as “endpoints.” A “digital endpoint” is defined by its use sensor-generated data often collected outside clinical setting such in patient’s free-living environment. Applicable sensors exist an array devices can be applied diverse contexts. For example, smartphone’s microphone might used diagnose or predict mild cognitive impairment due Alzheimer’s wrist-worn activity monitor (such those found smartwatches) may measure drug’s effect on the nocturnal patients with sickle cell disease. Digital endpoints generating considerable excitement because they permit more authentic experience, reveal formerly untold realities burden, cut drug discovery costs half. However, before these benefits realized, effort must not only technical creation digital but also environment that allows for their development application. future rests meaningful interdisciplinary collaboration, sufficient evidence realize promise, ecosystem which vast quantities generate analyzed. fundamental nature care changing. With coronavirus 2019 serving catalyst, there has been rapid expansion home models, telehealth, remote patient monitoring. increasing adoption health-care innovations will expedite requirement characterization current tools rely upon direct interaction thus fit purpose administered remotely. ubiquity relatively inexpensive sensors, positioned drive this consequential change. It therefore surprising regulators, physicians, researchers, consultants have each offered novel tools. we further describe later, broad require cooperative effort. In article, present analysis state endpoints. We attempt unify perspectives parties involved deployment conclude interdependent list challenges collaboratively addressed widely adopted.

Language: Английский

From Recognition to Remedy: The Significance of Biomarkers in Neurodegenerative Disease Pathology DOI Open Access
Corneliu Toader,

Nicolaie Dobrin,

Felix-Mircea Brehar

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(22), P. 16119 - 16119

Published: Nov. 9, 2023

With the inexorable aging of global populace, neurodegenerative diseases (NDs) like Alzheimer’s disease (AD), Parkinson’s (PD), and amyotrophic lateral sclerosis (ALS) pose escalating challenges, which are underscored by their socioeconomic repercussions. A pivotal aspect in addressing these challenges lies elucidation application biomarkers for timely diagnosis, vigilant monitoring, effective treatment modalities. This review delineates quintessence realm NDs, elucidating various classifications indispensable roles. Particularly, quest novel AD, transcending traditional markers PD, frontier biomarker research ALS scrutinized. Emergent susceptibility trait herald a new era personalized medicine, promising enhanced initiation especially cases SOD1-ALS. The discourse extends to diagnostic state markers, revolutionizing early detection alongside progression that unveil trajectory propelling forward potential tailored interventions. synergy between burgeoning technologies innovative techniques -omics, histologic assessments, imaging is spotlighted, underscoring roles discovery. Reflecting on progress hitherto, underscores exigent need multidisciplinary collaborations surmount ahead, accelerate discovery, epoch understanding managing NDs. Through panoramic lens, this article endeavors provide comprehensive insight into field spotlighting promise they hold transforming landscape, enhancing management, illuminating pathway toward efficacious therapeutic

Language: Английский

Citations

27
An update on the role of magnetic resonance imaging in predicting and monitoring multiple sclerosis progression DOI Creative Commons
Piriyankan Ananthavarathan, Nitin Sahi, Declan Chard

et al.

Expert Review of Neurotherapeutics, Journal Year: 2024, Volume and Issue: 24(2), P. 201 - 216

Published: Jan. 18, 2024

Introduction While magnetic resonance imaging (MRI) is established in diagnosing and monitoring disease activity multiple sclerosis (MS), its utility predicting progression less clear.

Language: Английский

Citations

11
Functional Connectivity in Multiple Sclerosis: Recent Findings and Future Directions DOI Creative Commons
Marlene Tahedl, Seth M. Levine, Mark W. Greenlee

et al.

Frontiers in Neurology, Journal Year: 2018, Volume and Issue: 9

Published: Oct. 11, 2018

Multiple sclerosis is a debilitating disorder resulting from scattered lesions in the central nervous system. Because of high variability lesion patterns between patients, it difficult to relate existing biomarkers symptoms and their progression. The nature multiple offers itself be studied through lens network analyses. Recent research into has taken such approach by making use functional connectivity. In this review, we briefly introduce measures connectivity how compute them. We then identify several common observations approach: (a) likelihood altered deep-gray matter regions, (b) decrease brain modularity, (c) hemispheric asymmetries alterations, (d) correspondence behavioral with task-related task-unrelated networks. propose incorporating analyses longitudinal studies order improve our understanding underlying mechanisms affected sclerosis, which can consequently offer promising route individualizing imaging-related for sclerosis.

Language: Английский

Citations

83
Hyperpolarized 13 C MR metabolic imaging can detect neuroinflammation in vivo in a multiple sclerosis murine model DOI Open Access
Caroline Guglielmetti, Chloé Najac, Alessandro Didonna

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2017, Volume and Issue: 114(33)

Published: July 31, 2017

Significance Cells from the innate immune system, namely microglia and macrophages (mononuclear phagocytes, MPs), play a central role in progression of neurological disorders such as multiple sclerosis. Such cells can contribute to lesion formations (proinflammatory) or participate remyelinating processes (neuroprotective). When differentiated proinflammatory phenotype, MPs experience metabolic reprogramming leading increased glycolysis production lactate. In this study we showed that new imaging method, 13 C magnetic resonance spectroscopic (MRSI) hyperpolarized pyruvate, detect lactate MPs, mechanism mediated by pyruvate dehydrogenase kinase 1 upregulation, preclinical model These findings validate potential MRSI for vivo detection neuroinflammation.

Language: Английский

Citations

78
Cognitive Profiles of Aging in Multiple Sclerosis DOI Creative Commons
Dejan Jakimovski, Bianca Weinstock‐Guttman,

Shumita Roy

et al.

Frontiers in Aging Neuroscience, Journal Year: 2019, Volume and Issue: 11

Published: May 10, 2019

Increasingly favorable mortality prognosis in multiple sclerosis (MS) raises questions regarding MS-specific cognitive aging and the presence of comorbidities such as Alzheimer's disease (AD).To assess elderly with MS (EwMS) age-matched healthy controls (HCs) using both MS- AD-specific psychometrics.EwMS (n = 104) 56 HCs were assessed on a broad spectrum language, visual-spatial processing, memory, processing speed, executive function tests. Using logistic regression analysis, we examined performance differences between EwMS HC groups. Cognitive impairment (CI) was defined -1.5 SD threshold relative to age education years-matched HCs, two domains.CI observed 47.1% most often seen tests emphasizing speed measured by Symbol Digit Modalities Test (SDMT) (d 0.9, p < 0.001) verbal fluency (both category-based d 0.87, 0.001; letter-based 0.67, 0.001). After adjusting for age, sex years education, MS/HC diagnosis best predicted (R2 0.27) (Wald 9.935, 0.002) SDMT 13.937, 0.001).This study confirms common hallmark slowed among patients. Defective fluency, less younger cohorts, may represent emerging pathology due other etiologies.

Language: Английский

Citations

62
Validity and Reliability of the Turkish Canadian Occupational Performance Measure (COPM-TR) for People with Multiple Sclerosis DOI
Berkan Torpil, Gamze Ekici, Gonca Bumin

et al.

Occupational Therapy In Health Care, Journal Year: 2021, Volume and Issue: 35(3), P. 306 - 317

Published: June 14, 2021

The Canadian Occupational Performance Measure (COPM) is a generic questionnaire based on semi-structured interview. We aimed to translate Turkish version of the COPM (COPM-TR) and assess its reliability validity. COPM-TR was administered 82 participants (42.2 ± 11.6 years 32.9% were male) with multiple sclerosis (MS) for convergent validity analysis. Multiple Sclerosis Quality Life-54 (MSQoL-54), Expanded Disability Status Scale (EDSS) determine Test-retest (a week interval) assessed by Intraclass Correlation Coefficient (ICC). There moderately strong negative correlations between EDSS performance satisfaction score COPM-TR. positive MSQoL-54 physical moderate Moderate found mental scores. Test re-test indicated excellent reliability. current study demonstrates that valid reliable tool measuring perceived occupational people MS.

Language: Английский

Citations

44
Understanding lifestyle self-management regimens that improve the life quality of people living with multiple sclerosis: a systematic review and meta-analysis DOI Creative Commons
Olivia Wills, Yasmine Probst

Health and Quality of Life Outcomes, Journal Year: 2022, Volume and Issue: 20(1)

Published: Nov. 25, 2022

Abstract Background Lifestyle self-management as an intervention for people living with multiple sclerosis (plwMS) is emerging area of research. Previous reviews have highlighted a need to systematically identify effective regimens that influence the health and well-being plwMS using common metric success. Objectives To examine effectiveness lifestyle strategies interventions aimed at improving quality life (QOL), and/or disability plwMS. The review also narratively explore elements were outcomes interest. Methods A systematic search was performed five scientific databases. process followed Cochrane Handbook Systematic Reviews Interventions registered PROSPERO (Ref: CRD42021235982). Results total 57 studies including 5830 individuals diagnosed MS, met inclusion criteria. Self-management included physical activity, fatigue, dietary, stress/coping, emotional, symptom medical management, wellbeing programs. Self-reported QOL improved in 35 47 studies. Dietary had no statistically significant overall effect on reducing MS disability, ( P = 0.18). Heterogeneity limited ability pool effects from large number eligible same design. Conclusion Multicomponent interventions, multimodal delivery methods, cognitive behavioural theory principles However, these results should be interpreted caution care taken its clinical application. This has potential inform future management practices revealed gap literature, warranting high-quality, large-scale experimental, observational address management.

Language: Английский

Citations

30
Prognostic models for predicting clinical disease progression, worsening and activity in people with multiple sclerosis DOI
Kelly Reeve, Begüm Irmak Ön, Joachim Havla

et al.

Cochrane library, Journal Year: 2023, Volume and Issue: 2023(9)

Published: Sept. 8, 2023

Language: Английский

Citations

20
Evolution of Patient-Reported Outcomes and Their Role in Multiple Sclerosis Clinical Trials DOI Creative Commons
Cindy J. Nowinski, Deborah Miller, David Cella

et al.

Neurotherapeutics, Journal Year: 2017, Volume and Issue: 14(4), P. 934 - 944

Published: Sept. 14, 2017

Language: Английский

Citations

61
Resolving the clinico-radiological paradox in multiple sclerosis DOI Creative Commons
Declan Chard,

S. Anand Trip

F1000Research, Journal Year: 2017, Volume and Issue: 6, P. 1828 - 1828

Published: Oct. 12, 2017

Understanding the clinico-radiological paradox is important in search for more sensitive and specific surrogates of relapses disability progression (such that they can be used to inform treatment choices individual people with multiple sclerosis) gain a better understanding pathophysiological basis sclerosis (to identify assess key therapeutic targets). In this brief review, we will consider themes issues underlying recent advances its resolution.

Language: Английский

Citations

59