Nutrients,
Journal Year:
2024,
Volume and Issue:
16(19), P. 3378 - 3378
Published: Oct. 4, 2024
Background/Objectives:
This
review
aims
to
provide
a
detailed
understanding
of
the
current
evidence
on
Alpinia
officinarum
Hance
(A.
officinarum)
and
its
potential
therapeutic
role
in
central
nervous
system
(CNS)
disorders.
CNS
disorders
encompass
wide
range
affecting
brain
spinal
cord,
leading
various
neurological,
cognitive
psychiatric
impairments.
In
recent
years,
natural
products
have
emerged
as
neuroprotective
agents
for
treatment
due
their
outstanding
bioactivity
favourable
safety
profile.
One
such
plant
is
A.
officinarum,
also
known
lesser
galangal,
perennial
herb
from
Zingiberaceae
family.
Its
phytochemical
compounds
flavonoids
phenols
been
documented
powerful
antioxidants
effect,
capable
scavenging
free
radicals
preventing
oxidative
damage.
Methods:
this
review,
we
critically
evaluate
vitro
vivo
studies
examine
mechanisms
by
which
exerts
effect.
Results:
Several
confirmed
that
effects
reducing
stress
cell
apoptosis,
promoting
neurite
outgrowth,
modulating
neurotransmitter
levels
signalling
pathways.
Conclusions:
Although
previous
shown
promising
results
models
neurological
disorders,
underlying
Alzheimer’s
(AD)
Parkinson’s
disease
(PD)
are
still
poorly
understood.
Further
tissue
motor
functions
animal
AD
PD
needed
validate
observed
studies.
addition,
further
clinical
confirm
efficacy
Epilepsia Open,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 9, 2025
Abstract
Genetic
epilepsy
with
myoclonic
seizures
encompasses
a
heterogeneous
spectrum
of
conditions,
ranging
from
benign
and
self‐limiting
forms
to
severe,
progressive
disorders.
While
their
causes
are
diverse,
significant
proportion
stems
genetic
abnormalities.
Advances
in
research
over
the
past
decade
have
uncovered
novel
mechanisms
underlying
these
disorders,
including
single‐gene
mutations,
copy
number
variations
(CNVs),
non‐coding
repeat
expansions.
These
findings
not
only
deepen
our
understanding
pathophysiology
but
also
highlight
potential
avenues
for
precision
medicine.
This
review
provides
comprehensive
overview
epilepsies
linked
pathogenic
gene
variants,
exploring
discussing
clinical
implications.
Plain
Language
Summary
In
this
work,
we
describe
mainly
characterized
by
seizures,
defects
disease
mechanisms,
considerations
medicine
treatment.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(19), P. 3378 - 3378
Published: Oct. 4, 2024
Background/Objectives:
This
review
aims
to
provide
a
detailed
understanding
of
the
current
evidence
on
Alpinia
officinarum
Hance
(A.
officinarum)
and
its
potential
therapeutic
role
in
central
nervous
system
(CNS)
disorders.
CNS
disorders
encompass
wide
range
affecting
brain
spinal
cord,
leading
various
neurological,
cognitive
psychiatric
impairments.
In
recent
years,
natural
products
have
emerged
as
neuroprotective
agents
for
treatment
due
their
outstanding
bioactivity
favourable
safety
profile.
One
such
plant
is
A.
officinarum,
also
known
lesser
galangal,
perennial
herb
from
Zingiberaceae
family.
Its
phytochemical
compounds
flavonoids
phenols
been
documented
powerful
antioxidants
effect,
capable
scavenging
free
radicals
preventing
oxidative
damage.
Methods:
this
review,
we
critically
evaluate
vitro
vivo
studies
examine
mechanisms
by
which
exerts
effect.
Results:
Several
confirmed
that
effects
reducing
stress
cell
apoptosis,
promoting
neurite
outgrowth,
modulating
neurotransmitter
levels
signalling
pathways.
Conclusions:
Although
previous
shown
promising
results
models
neurological
disorders,
underlying
Alzheimer’s
(AD)
Parkinson’s
disease
(PD)
are
still
poorly
understood.
Further
tissue
motor
functions
animal
AD
PD
needed
validate
observed
studies.
addition,
further
clinical
confirm
efficacy
