Neurological Implications of Poxvirus Infections: Pathogenesis, Neurotropism, and Clinical Manifestations DOI
Mohammed Alissa, Khalid J. Alzahrani, Meshari A. Alsuwat

et al.

Reviews in Medical Virology, Journal Year: 2024, Volume and Issue: 34(5)

Published: Sept. 1, 2024

Poxviridae is a diverse family of double-stranded DNA viruses, historically significant for diseases like smallpox caused by variola virus (VARV). These viruses exhibit unique cytoplasmic replication strategies, large genomes encoding numerous proteins, and the ability to cause severe cutaneous systemic diseases. Recent attention has focused on their neurotropic potential, including mechanisms CNS invasion, immune-mediated damage, clinical manifestations such as encephalitis myelitis. This review synthesises current knowledge poxvirus neurotropism, highlighting pathophysiological implications.

Language: Английский

Preparation, and ex vivo and in vivo Characterization of Favipiravir-Loaded Aspasomes and Niosomes for Nose-to-Brain Administration DOI Creative Commons
Maryana Salamah, Balázs Volk, István Lekli

et al.

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 6489 - 6514

Published: May 1, 2025

Language: Английский

Citations

0
Optimization of antiviral dosing in Herpesviridae encephalitis: a promising approach to improve outcome? DOI
Roland Nau, Jana Seele, Jacob Bodilsen

et al.

Clinical Microbiology and Infection, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

Citations

1
Revisiting acyclovir dosing for viral encephalitis using a Bayesian PBPK modeling approach DOI Creative Commons

Ming Sun,

Martijn L. Manson, Anne‐Grete Märtson

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 26, 2024

Abstract Acyclovir is a primary treatment for central nervous system (CNS) infections caused by herpes simplex virus (HSV) and varicella-zoster (VZV). However, patient outcomes remain suboptimal with high mortality morbidity, following current dosing guidelines. Given the lack of alternative therapies, there pressing need to optimize acyclovir dosing, especially since initial regimens were developed in 1980s incomplete pharmacokinetic data CNS. This study aimed evaluate both using full Bayesian physiologically-based (PBPK) model tailored viral encephalitis. We CNS PBPK simulate concentrations plasma, brain extracellular fluid (ECF), subarachnoid space (SAS). Drug efficacy was assessed two targets, 50% f T>IC 50 C min >IC , safety threshold set at 25 mg/L plasma. The standard regimen (10 mg/kg TID) yielded sufficient exposure (SAS) compartments based on target. it did not consistently meet target, indicating potential these when evaluated against this criterion. Notably, higher probability target attainment (PTA) generally observed ECF SAS compared Increasing frequency QID improved but exceeded toxicity 20 mg/kg. Our findings suggest that 10 or 15 may offer more effective safer approach managing other tested regimens.

Language: Английский

Citations

0
Neurological Implications of Poxvirus Infections: Pathogenesis, Neurotropism, and Clinical Manifestations DOI
Mohammed Alissa, Khalid J. Alzahrani, Meshari A. Alsuwat

et al.

Reviews in Medical Virology, Journal Year: 2024, Volume and Issue: 34(5)

Published: Sept. 1, 2024

Poxviridae is a diverse family of double-stranded DNA viruses, historically significant for diseases like smallpox caused by variola virus (VARV). These viruses exhibit unique cytoplasmic replication strategies, large genomes encoding numerous proteins, and the ability to cause severe cutaneous systemic diseases. Recent attention has focused on their neurotropic potential, including mechanisms CNS invasion, immune-mediated damage, clinical manifestations such as encephalitis myelitis. This review synthesises current knowledge poxvirus neurotropism, highlighting pathophysiological implications.

Language: Английский

Citations

0