A New Perspective on Agitation in Alzheimer’s Disease: A Potential Paradigm Shift DOI Open Access
John R. Østergaard

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3370 - 3370

Published: April 4, 2025

Agitation is a common and difficult-to-manage neuropsychiatric syndrome in dementia. Recently, an association with the autonomous nervous system has been suggested. From literature researched, however, only two studies investigating autonomic function concomitant to agitation situations appeared; one case series comprised American veterans vascular Alzheimer's dementia, respectively, of patients CLN3 (juvenile neuronal ceroid lipofuscinosis), this was found be most neurodegenerative disease leading dementia childhood. In both series, measurement disclosed parasympathetic withdrawal sympathetic hyperactivity temporal context agitated behavior. If time-wise-related imbalance shown previously can demonstrated larger cohort disease, use transcutaneous vagal stimulation might potential paradigm shift treatment disease.

Language: Английский

Perspective Chapter: The Neuropsychological Dimension of Psychosis – Implications for Assessment and Treatment DOI Creative Commons
Sotiria Moza,

Savvina Chrysostomou

IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

Psychotic Spectrum Disorders (PSDs) affect approximately 1 in 300 people worldwide and encompass a range of positive symptoms, such as hallucinations, delusions, disorganized thinking, well negative including alogia, avolition, diminished emotional expression. In addition, with PSDs frequently present impairments cognitive domains, executive function, memory, attention, social cognition, which lead to difficulties independent living, employment, interpersonal relationships. This chapter explores the neuropsychological dimension psychosis provides thorough summary deficits linked PSDs. The neurobiological underpinnings these are discussed, examining PSD differentiations brain structure function. Instruments used for evaluation presented, supporting crucial role formal plays diagnosis treatment. Modern therapeutic modalities, remediation therapies, pharmaceutical interventions, technologies like neurostimulation digital therapeutics, discussed. closes by discussing implications future study clinical application, highlighting necessity integrated, culturally relevant, ethical approaches rehabilitation symptom management. Through this work, authors aim support better understanding promote more efficient, comprehensive care

Language: Английский

Citations

0
A New Perspective on Agitation in Alzheimer’s Disease: A Potential Paradigm Shift DOI Open Access
John R. Østergaard

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3370 - 3370

Published: April 4, 2025

Agitation is a common and difficult-to-manage neuropsychiatric syndrome in dementia. Recently, an association with the autonomous nervous system has been suggested. From literature researched, however, only two studies investigating autonomic function concomitant to agitation situations appeared; one case series comprised American veterans vascular Alzheimer's dementia, respectively, of patients CLN3 (juvenile neuronal ceroid lipofuscinosis), this was found be most neurodegenerative disease leading dementia childhood. In both series, measurement disclosed parasympathetic withdrawal sympathetic hyperactivity temporal context agitated behavior. If time-wise-related imbalance shown previously can demonstrated larger cohort disease, use transcutaneous vagal stimulation might potential paradigm shift treatment disease.

Language: Английский

Citations

0