Prenatal and Early Childhood Exposure to Antibiotics or Gastric Acid Inhibitors and Increased Risk of Epilepsy: A Nationwide Population‐Based Study
Clinical Pharmacology & Therapeutics,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 15, 2025
Over
10
million
children
in
the
world
have
epilepsy,
with
an
unknown
cause
half
of
cases.
The
gut
microbiome
has
been
associated
various
neurological
disorders,
and
certain
drugs
greatly
disturb
microbiome.
Our
aim
was
to
study
association
prenatal
childhood
exposure
(before
age
two)
antibiotics,
proton
pump
inhibitors
(PPIs)
histamine‐2
receptor
antagonists,
risk
epilepsy.
Using
population‐based
registers,
we
included
all
live
singleton
births
Sweden
from
2006
2017.
Exposure
considered
prescription(s)
inhibitors,
or
H2‐receptor
antagonists
(separately).
Multivariable
Cox
regression
used
calculate
hazard
ratios
95%
confidence
intervals.
708,903
mother–child
dyads
were
included,
0.5%
had
epilepsy
diagnosis.
Average
follow‐up
3.8
years
(IQR
1–6).
Prenatal
antibiotics
(aHR
1.09,
CI
1.01–1.18)
PPIs
1.38,
1.17–1.65)
increased
(1.11,
1.02–1.21),
(3.40,
2.47–4.68)
H2RAs
(1.65,
1.03–2.64)
before
two
after
two.
Dose
response
analysis
showed
that
one
prescription
pregnancy
early
life
not
while
association.
To
conclude,
our
results
support
hypothesis
modulating
are
This
needs
be
further
validated
other
studies,
ideally
including
indications
for
drug
use.
Language: Английский
Proton pump inhibitors and the risk of gastric cancer: a systematic review, evidence synthesis and life course epidemiology perspective
BMJ Open Gastroenterology,
Journal Year:
2025,
Volume and Issue:
12(1), P. e001719 - e001719
Published: April 1, 2025
Objectives
Since
proton
pump
inhibitors
(PPI)
have
been
introduced,
many
concerns
were
raised
regarding
potential
gastric
carcinogenicity.
We
aim
to
summarise
and
weigh
the
epidemiological
evidence
address
possible
causality.
Design
Systematic
literature
review,
synthesis
life-course
assessment.
Data
sources
PubMed,
Web
of
Science
Cochrane
database
(from
inception
up
October
2024),
back-
forward
citation
tracking
(Web
Science).
Eligibility
criteria
Original
studies
quantitative
syntheses
assessing
association
between
PPIs
cancer
in
humans,
without
language
restrictions.
extraction
Study
design,
definitions
(and
participant
numbers)
PPI
use
cancer,
study
characteristics
(setting,
period,
follow-up,
lag-time),
age
sex
distribution
presented
tables
mapping.
Results
identified
33
original
studies,
21
meta-analyses,
three
umbrella
one
individual
patient
data
meta-analysis
a
Markov
model
(2006–2023).
consistently
associated
with
an
increased
risk
20/21
meta-analyses
reporting
pooled
relative
risks
1.3
2.9.
Available
trials
underpowered.
Reverse
causation/protopathic
bias,
residual
confounding
(by
indication)
lag
time
seem
largest
methodological
challenges,
as
well
disentangling
effects
Helicobacter
pylori
its’
eradication.
Insufficient
are
available
on
sex-specific
risks,
no
specifically
addressing
young
populations.
hypothesise
sensitive-period
exposure
model,
which
during
pregnancy
early
life
may
be
particularly
damaging
long-term
risk.
An
exploration
Swedish
incidence
suggests
cohort
overall
decreased
over
(1970–2022).
The
has
(<40
years)
men
since
2000s,
~10
years
after
introduction
eradication
PPIs.
Conclusion
Although
for
older
individuals
valid
indications,
related
limited,
we
do
argue
more
rational
evidence-supported
Language: Английский
Prenatal and Early Childhood Exposure to Proton Pump Inhibitors and Antibiotics and the Risk of Childhood Cancer: A Nationwide Population-Based Cohort Study
Drug Safety,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 12, 2024
Our
microbiome
is
established
during
infancy,
a
time
important
for
later
health
and
long-term
effects.
Proton
pump
inhibitors
antibiotics
are
regularly
prescribed
pregnancy.
Both
drugs
cause
disturbance
have
been
associated
with
increased
cancer
risk
in
adults,
but
effects
of
these
on
the
growing
foetus
infant
remain
understudied.
The
aim
this
study
to
association
between
prenatal
early
life
proton
inhibitor
exposure
childhood
cancer.
This
retrospective
population-based
cohort
design,
using
registry
data
all
births
(n
=
722,372)
Sweden
2006
2016,
according
STROBE
checklist.
For
women
who
had
multiple
children
timeframe
study,
only
first
child
period
was
included
cohort.
Exposure
defined
as
either
≥
1
or
prescription
pregnancy,
2
years
life.
Outcome
at
any
follow-up
after
age
exposure.
Multivariable
Cox
proportional
hazard
models
were
used
calculate
ratios.
In
total,
1091
(0.2%)
diagnosed
malignant
follow-up.
Prenatal
not
an
Regarding
exposure,
two
older
(adjusted
ratio
[aHR]
3.68,
95%
confidence
interval
[CI]
2.24–6.06).
We
did
find
evidence
that
overall
However,
cancer,
indication
drug
use
available
confounding
by
may
be
present.
Language: Английский