Anti-Cancer Potential of Cannabinoids, Terpenes, and Flavonoids Present in Cannabis

Cancers, Journal Year: 2020, Volume and Issue: 12(7), P. 1985 - 1985

Published: July 21, 2020

In recent years, and even more since its legalization in several jurisdictions, cannabis the endocannabinoid system have received an increasing amount of interest related to their potential exploitation clinical settings. Cannabinoids been suggested shown be effective treatment various conditions. cancer, is altered numerous types tumours can relate cancer prognosis disease outcome. Additionally, cannabinoids display anticancer effects models by suppressing proliferation, migration and/or invasion cells, as well tumour angiogenesis. However, therapeutic use currently limited symptoms pain associated with chemotherapy, while cytotoxic drugs chemotherapy still requires validation patients. Along cannabinoids, contains other compounds that also exert anti-tumorigenic actions. The anti-cancer terpenes flavonoids, present cannabis, are explored this literature review.

Language: Английский

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Therapeutic Approaches for Peripheral and Central Neuropathic Pain

Behavioural Neurology, Journal Year: 2019, Volume and Issue: 2019, P. 1 - 13

Published: Nov. 21, 2019

Neuropathic pain is a chronic secondary condition, which consequence of peripheral or central nervous (somatosensory) system lesions diseases. It devastating affects around 7% the general population. Numerous etiological factors contribute to development neuropathic pain. can originate from part such as in case trigeminal postherpetic neuralgia, nerve injury, painful polyneuropathies, radiculopathies. Central develop result spinal cord brain stroke, multiple sclerosis. As first-line pharmacological treatment options, tricyclic antidepressants, serotonin-norepinephrine reuptake inhibitors, and gabapentinoids are recommended. In carbamazepine oxcarbazepine first-choice drugs. drug-refractory cases, interventional, physical, psychological therapies available. This review was structured based on PubMed search papers published field 2010 until May 2019.

Language: Английский

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Cannabinoids: Therapeutic Use in Clinical Practice

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(6), P. 3344 - 3344

Published: March 19, 2022

Medical case reports suggest that cannabinoids extracted from Cannabis sativa have therapeutic effects; however, the employment is limited due to psychotropic effect of its major component, Δ9-tetrahydrocannabinol (THC). The new scientific discoveries related endocannabinoid system, including receptors, ligands, and mediators, allowed development targets for treatment several pathological disorders minimizing undesirable effects some constituents this plant. Today, FDA-approved drugs, such as nabiximols (a mixture THC non-psychoactive cannabidiol (CBD)), are employed in alleviating pain spasticity multiple sclerosis. Dronabinol nabilone used chemotherapy-induced nausea vomiting cancer patients. was approved anorexia patients with AIDS (acquired immune deficiency syndrome). In review, we highlighted potential efficacy natural synthetic their clinical relevance cancer, neurodegenerative dermatological diseases, viral infections.

Language: Английский

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Prevalence and self-reported reasons of cannabis use for medical purposes in USA and Canada

Psychopharmacology, Journal Year: 2022, Volume and Issue: 239(5), P. 1509 - 1519

Published: Jan. 12, 2022

There has been increasing attention on cannabis use for medical purposes, but there is currently a lack of data its epidemiology.To examine the epidemiology self-reported purposes by (1) estimating prevalence, (2) comparing gender and age differences, (3) investigating what reasons they were used to manage.Participants included 27,169 respondents (aged 16-65) who completed Wave 1 The International Cannabis Policy Study (ICPS) conducted across Canada USA in 2018 via online surveys. policy conditions "US legal-recreational" (legal both recreational uses), legal-medical only", illegal", "Canada-medical only".The overall prevalence ever was 27%, with similar rates sex highest young adults. Prevalence higher US legal-recreational states (34%) than illegal (23%), only (25%), (25%). most common physical health include manage pain (53%), sleep (46%), headaches/migraines (35%), appetite (22%), nausea/vomiting (21%). For mental reasons, anxiety (52%), depression (40%), PTSD/trauma (17%). 11% reported using managing other drug or alcohol 4% psychosis.A substantial proportion North American population variety including those living jurisdictions without legal markets. Further research needed understand safety efficacy these forms use.

Language: Английский

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Small molecules in the treatment of COVID-19

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: Dec. 5, 2022

Abstract The outbreak of COVID-19 has become a global crisis, and brought severe disruptions to societies economies. Until now, effective therapeutics against are in high demand. Along with our improved understanding the structure, function, pathogenic process SARS-CoV-2, many small molecules potential anti-COVID-19 effects have been developed. So far, several antiviral strategies were explored. Besides directly inhibition viral proteins such as RdRp M pro , interference host enzymes including ACE2 proteases, blocking relevant immunoregulatory pathways represented by JAK/STAT, BTK, NF-κB, NLRP3 pathways, regarded feasible drug development. development treat achieved strategies, computer-aided lead compound design screening, natural product discovery, repurposing, combination therapy. Several representative remdesivir paxlovid proved or authorized emergency use countries. And candidates entered clinical-trial stage. Nevertheless, due epidemiological features variability issues it is necessary continue exploring novel COVID-19. This review discusses current findings for treatment. Moreover, their detailed mechanism action, chemical structures, preclinical clinical efficacies discussed.

Language: Английский

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Evolution, genetics and biochemistry of plant cannabinoid synthesis: a challenge for biotechnology in the years ahead

Current Opinion in Biotechnology, Journal Year: 2022, Volume and Issue: 75, P. 102684 - 102684

Published: Jan. 24, 2022

Cannabis sativa is most prominent for its psychoactive secondary compound tetrahydrocannabinol, or THC. However, THC only one of many phytocannabinoids found in this (in)famous medicinal plant. The stepwise legalization countries has opened opportunities and commercial use, sparking scientific interest the genetics biochemistry phytocannabinoid synthesis. Advances plant biology genomics help to accelerate research field, which still lagging behind other comparable high-value crops. Here, we discuss intriguing evolutionary history synthases, also show that an increased understanding developmental morphology are critical importance leverage full potential production.

Language: Английский

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Medicinal Cannabis—Potential Drug Interactions

Medicines, Journal Year: 2018, Volume and Issue: 6(1), P. 3 - 3

Published: Dec. 23, 2018

The endocannabinoids system (ECS) has garnered considerable interest as a potential therapeutic target in various carcinomas and cancer-related conditions alongside neurodegenerative diseases. Cannabinoids are implemented several physiological processes such appetite stimulation, energy balance, pain modulation the control of chemotherapy-induced nausea vomiting (CINV). However, pharmacokinetics pharmacodynamics interactions could be perceived drug combinations, so this short review we tried to shed light on medicinal cannabis. Hitherto, few data have been provided healthcare practitioners about drug⁻drug cannabinoids with other prescription medications. In general, usually well tolerated, but bidirectional effects may expected concomitant administered agents via affected membrane transporters (Glycoprotein p, breast cancer resistance proteins, multidrug proteins) metabolizing enzymes (Cytochrome P450 UDP-glucuronosyltransferases). Caution should undertaken closely monitor responses cannabis users certain drugs guard their safety, especially for elderly people chronic diseases or kidney liver conditions.

Language: Английский

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Single-Dose Pharmacokinetics and Preliminary Safety Assessment with Use of CBD-Rich Hemp Nutraceutical in Healthy Dogs and Cats

Animals, Journal Year: 2019, Volume and Issue: 9(10), P. 832 - 832

Published: Oct. 19, 2019

The use of CBD-rich hemp products is becoming popular among pet owners with no long-term safety data related to consumption in adult dogs and cats. purpose this study was determine the single-dose oral pharmacokinetics CBD, provide a preliminary assessment adverse effects during 12-week administration using hemp-based product healthy Eight each species were provided 2 mg/kg total CBD concentration orally twice daily for 12 weeks screening six species. Pharmacokinetics revealed mean maximum (Cmax) 301 ng/mL 43 ng/mL, area under curve (AUC) 1297 ng-h/mL 164 ng-h/mL, time maximal (Tmax) 1.4 h h, cats, respectively. Serum chemistry CBC results showed clinically significant alterations, however one cat persistent rise alanine aminotransferase (ALT) above reference range duration trial. In an supplement administered every not detrimental based on or biochemistry values. Cats do appear absorb eliminate differently than dogs, showing lower serum concentrations excessive licking head-shaking oil administration.

Language: Английский

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Cannabidiol differentially regulates basal and LPS-induced inflammatory responses in macrophages, lung epithelial cells, and fibroblasts

Toxicology and Applied Pharmacology, Journal Year: 2019, Volume and Issue: 382, P. 114713 - 114713

Published: Aug. 19, 2019

Language: Английский

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Cannabis sativa: Much more beyond Δ9-tetrahydrocannabinol

Pharmacological Research, Journal Year: 2020, Volume and Issue: 157, P. 104822 - 104822

Published: April 23, 2020

Language: Английский

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