Monocytic HLA-DR Expression in Immune Responses of Acute Pancreatitis and COVID-19

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(4), P. 3246 - 3246

Published: Feb. 7, 2023

Acute pancreatitis is a common gastrointestinal disease with increasing incidence worldwide. COVID-19 potentially life-threatening contagious spread throughout the world, caused by severe acute respiratory syndrome coronavirus 2. More forms of both diseases exhibit commonalities dysregulated immune responses resulting in amplified inflammation and susceptibility to infection. Human leucocyte antigen (HLA)-DR, expressed on antigen-presenting cells, acts as an indicator function. Research advances have highlighted predictive values monocytic HLA-DR (mHLA-DR) expression for severity infectious complications patients. While regulatory mechanism altered mHLA-DR remains unclear,

Language: Английский

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Acute Pancreatitis during and after Pregnancy: A Review

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(7), P. 2028 - 2028

Published: March 30, 2024

During pregnancy and in the post-partum period, several diseases may arise or become exacerbated. Acute pancreatitis is an inflammatory disease with increasing incidence Western countries. The of acute during not different respect to general population, but this increases first 2 years after delivery. Biliary sludge stones are most frequent aetiologies, followed by hypertriglyceridemia. Taking care mother foetus through a potentially severe requires team consisting obstetrician, gastroenterologist, anaesthesiologist, surgeon. It necessary monitor health foetus/child pregnancy, childbirth, puerperium. management depends on systemic local complications, severity pancreatitis, trimester pregnancy. Some diagnostic tools many drugs safe for foetuses, while interventional endoscopy surgery have limitations can only be used accurate evaluation benefit/risk ratios. Despite these limitations, maternal mortality due low mainly thanks multidisciplinary approaches patients. A careful diet prevent obesity, alcohol abstinence, routine serum triglyceride control, breastfeeding at least three months

Language: Английский

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The relationship between inflammatory cytokines and in‐hospital complications of acute pancreatitis

Immunity Inflammation and Disease, Journal Year: 2024, Volume and Issue: 12(2)

Published: Feb. 1, 2024

Acute necrotic collection (ANC), acute peripancreatic fluid (APFC), pleural effusion, and ascites are common early complications of pancreatitis. This study aimed to investigate the relationship between 12 serum cytokines severity pancreatitis (AP).

Language: Английский

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Blocking CIRP protects against acute pancreatitis by improving mitochondrial function and suppressing pyroptosis in acinar cells

Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)

Published: March 27, 2024

Abstract Acute pancreatitis (AP) continues to pose a major challenge as targeted therapeutic interventions are absent. Mitochondrial dysfunction and inflammasome-dependent pyroptosis involved in the pathogenic mechanisms of AP. CIRP is stress-response protein damage-associated molecular pattern (DAMP) molecule. In our previous studies, we discovered that excessive can directly damage pancreatic acinar cells. Nonetheless, precise involvement AP still unexplored. The primary aim this study was examine potential development mitochondrial To this, an L-arginine-induced mouse model used. Our results showed Caspase-1-mediated mitochondria-derived reactive oxygen species (ROS) were crucial factors occurrence tissue inflammation A substantial increase serum levels observed mice. Blocking by either gene knockout or systemic administration C23, competing inhibitor CIRP, reduced ROS accumulation These effects associated with attenuated injury inflammation. addition, CIRP-triggered dysfunction, autophagy impairment, cells prevented TAK242, receptor TLR4. conclusion, induce cells, blocking may be valuable approach treating patients

Language: Английский

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Integrated pharmacokinetic properties and tissue distribution of multiple active constituents in Qing-Yi Recipe: A comparison between granules and decoction

Phytomedicine, Journal Year: 2024, Volume and Issue: 129, P. 155645 - 155645

Published: April 15, 2024

Qing-Yi Recipe, a classic traditional Chinese medicine (TCM), is widely used for treating acute diseases of the abdomen, especially pancreatitis, efficacy which has been demonstrated in more than thirty clinical trials. However, in-vivo pharmacodynamic material basis this formula remains unclear. A sensitive and accurate method quantifying twenty-two potential bioactive constituents Recipe biological samples was developed using liquid chromatography-tandem mass spectrometry (LC-MS/MS), fully validated. Then, integrated pharmacokinetic properties its major metabolites rats were investigated post-listed granules at both dosages. Subsequently, tissue distributions those nine organs (especially pancreas) determined, overall parameters between two formulations compared. Though chemical profiles formulas varied across formulations, exposure level very similar, baicalin, wogonoside, geniposide, rhein, costunolide, paeoniflorin top six compounds circulation. All natural products reached their first peak within 2 h, several them exhibited bimodal or multimodal patterns under complicated transformation metabolic enzymes, these markedly changed compared with monomers. Diverse emodin baicalin/baicalein detected circulation tissues, augmenting vivo forms compounds. Finally, enrichment tetrahydropalmatine corydaline pancreas observed most remained gastrointestinal system, providing foundation regulatory effects on gut microbiota as well intestinal functions. Herein, distribution multiple active dosages, time. This investigation expected to provide new perspective reference future studies physiological disposition treat abdomen diseases.

Language: Английский

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