Drug Treatment Direction Based on the Molecular Mechanism of Breast Cancer Brain Metastasis DOI Creative Commons
Yumin Zhang,

Haotian Shang,

Jiaxuan Zhang

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(2), P. 262 - 262

Published: Feb. 16, 2025

Today, breast cancer (BC) is the most frequently diagnosed malignancy and a leading cause of cancer-related deaths among women worldwide. Brain metastases (BMs) are common complication individuals with advanced cancer, significantly impacting both survival rates overall condition life patients. This review systematically analyzes innovative approaches to drug treatment for brain (BCBMs), particular emphasis placed on treatments targeting molecular mechanisms signaling pathways delivery strategies blood barrier (BBB). The article discusses various drugs that have demonstrated effectiveness against BCBM, featuring mix monoclonal antibodies, nimble small-molecule tyrosine kinase inhibitors (TKIs), antibody-drug conjugates (ADCs). study techniques designed boost permeability BBB sheds light how these innovations can improve metastases. highlights need develop new therapies BCBM optimize existing strategies. With deeper comprehension intricate advances in technology, it expected more effective personalized options will become available future patients BCBM.

Language: Английский

Drug Treatment Direction Based on the Molecular Mechanism of Breast Cancer Brain Metastasis DOI Creative Commons
Yumin Zhang,

Haotian Shang,

Jiaxuan Zhang

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(2), P. 262 - 262

Published: Feb. 16, 2025

Today, breast cancer (BC) is the most frequently diagnosed malignancy and a leading cause of cancer-related deaths among women worldwide. Brain metastases (BMs) are common complication individuals with advanced cancer, significantly impacting both survival rates overall condition life patients. This review systematically analyzes innovative approaches to drug treatment for brain (BCBMs), particular emphasis placed on treatments targeting molecular mechanisms signaling pathways delivery strategies blood barrier (BBB). The article discusses various drugs that have demonstrated effectiveness against BCBM, featuring mix monoclonal antibodies, nimble small-molecule tyrosine kinase inhibitors (TKIs), antibody-drug conjugates (ADCs). study techniques designed boost permeability BBB sheds light how these innovations can improve metastases. highlights need develop new therapies BCBM optimize existing strategies. With deeper comprehension intricate advances in technology, it expected more effective personalized options will become available future patients BCBM.

Language: Английский

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