The Current Landscape of Pharmacotherapies for Sarcopenia

Drugs & Aging, Journal Year: 2024, Volume and Issue: 41(2), P. 83 - 112

Published: Feb. 1, 2024

Language: Английский

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Challenges, current innovations, and opportunities for managing type 2 diabetes in frail older adults: a position paper of the European Geriatric Medicine Society (EuGMS)—Special Interest Group in Diabetes

European Geriatric Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

This position paper aims to address the challenges of managing type 2 diabetes mellitus (T2DM) in frail older adults, a diverse and growing demographic with significant variability health status. The primary research questions are: How can frailty assessment be effectively integrated into care? What strategies optimize glycaemic control outcomes for adults? innovative tools technologies, including artificial intelligence (AI), improve management this population? uses 5 I's framework (Identification, Innovation, Individualization, Integration, Intelligence) integrate care, proposing such as tools, novel therapies, digital AI systems. It also examines metabolic heterogeneity, highlighting anorexic-malnourished sarcopenic-obese phenotypes. proposed highlights importance tailoring targets levels, prioritizing quality life, minimizing treatment burden. Strategies leveraging are emphasized their potential enhance personalized care. distinct needs two phenotypes outlined, specific recommendations each group. calls holistic, patient-centered approach care ensuring equity access innovations life. need fill evidence gaps, refine healthcare integration better vulnerable

Language: Английский

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Evaluating the Efficacy of a Sedentary Behavior Intervention on Self-Efficacy, Step Count, and frailty in Elderly Patients with Type 2 Diabetes Mellitus of Nursing Home

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

Background: This study aimed to explore the effects of interventions on improving self-efficacy, increasing physical activity, and reducing frailty associated with sedentary behavior in older people type 2 diabetes (OPT2DM). Methods: The convenient sampling method was employed select OPT2DM from six nursing homes Zhengzhou City, China, between July 2023 January 2024. Participants were randomly assigned control experimental groups. Prior intervention protocol, as well 8 weeks 16 post-intervention, subjects assessed using a general data questionnaire, Measure time (MOS), Self-efficacy for (SED), Frail-NH Debilitation Scale, step counts, Body Mass Index (BMI). Results: A total 92 cases included study, comprising 43 group 44 group. scores SED showed statistically significant improvement after (P < 0.05). counts steps taken exhibited differences both Additionally, demonstrated at 16-week mark broad estimation equation analysis indicated that intervention, groups significant, highlighting inter-group effects, interaction Conclusion: reduced among OPT2DM. These not only enhanced self-efficacy regarding management but also increased activity levels, ultimately overall well-being these participants.

Language: Английский

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Preparation of biomimetic MAO coating on β-Titanium alloy surface and its bone regeneration property in diabetic environment

Materials & Design, Journal Year: 2024, Volume and Issue: 239, P. 112808 - 112808

Published: Feb. 29, 2024

A biomimetic coating was prepared on β-titanium alloy surface using micro-arc oxidation to enhance its bone regeneration property in diabetic environment. The research probed into the complex interactions between crystalline phase, chemical composition, and morphology modulating osteoblast behavior. resultant displayed an open, porous structure, characterized by porosities ranging from 19.3 % 39.8 a roughness distribution spanning 22.9 37.9 nm. XRD XPS analyses confirmed hydroxyapatite crystal structure within coatings. Elemental quantification revealed Ca/P ratios 1.49 2.44, aligning closely with physiological ratio of 1.67. Under synergistic effects hyperglycemia advanced glycation end-products (AGES), Ca P ion release MAO expedited, thereby inducing osteogenic differentiation marrow stem cells. In addition, Ca2+ released would AGES, reducing inhibitory effect cell growth thus promoting proliferation. Cellular experiments showed that higher porosity beneficial ions facilitated environment promoted proliferation differentiation. This study utilized design corrosion phenomena provide theoretical basis for titanium alloys clinical applications.

Language: Английский

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Systematic review of guideline recommendations for older and frail adults with type 2 diabetes mellitus

Age and Ageing, Journal Year: 2024, Volume and Issue: 53(11)

Published: Nov. 1, 2024

Abstract Background The application of clinical practice guidelines (CPGs) across the spectrum individuals living with diabetes can be challenging, particularly in older adults, where factors such as frailty and multimorbidity exacerbate complexity management. Objective This systematic review aimed to explore guidance provided within CPGs for management who are and/or frail, including recommendations haemoglobin A1C (HbA1c) target pharmacotherapeutic Methods A search was completed Medline Embase identify national or international type 2 published last 10 years. Data extracted included HbA1c targets pharmacotherapy frail screening deprescribing. Quality appraised AGREE II tool. Results Twenty-three were included, which adults discussed 21 14 CPGs, respectively. Specific by 15 majority suggested a strict (&lt;7.0%–7.5%) healthier more relaxed (&lt;8.0%–8.5%) those medically complex. Ten insulin therapy 16 non-insulin antihyperglycaemic agents that specific populations, primarily focused on minimising risk hypoglycaemia. Conclusion Most recommend medical complexity. However, significant variability exists there proportionately less frail.

Language: Английский

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The current state and development trends of frailty research in diabetic patients: a bibliometric analysis

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: March 11, 2025

Background Diabetes mellitus is a global public health issue, often leading to organ damage, complications, and disabilities. Frailty an age-related syndrome characterized by reduced physiological reserve increased vulnerability stressors, significantly affecting the prognosis of older diabetic patients. The prevalence frailty notably higher in adults with diabetes than those without. Therefore, bibliometric analysis research on diabetes-related can provide deeper insights into current state this field inform future directions. Methods This study retrieved English-language publications from Web Science Core Collection (WOS) database, covering period 2005 2023. A total 403 articles were included analysis. Statistical data visualization conducted using Microsoft Excel, R Studio, VOS viewer, Cite Space 6.3.R1. emphasized journals, authors, keywords, country collaborations, institutional references elucidate trends knowledge structures within research. Results number has been steadily increasing each year, predominantly focused developed countries, particularly United States Europe. University London emerged as institution highest volume publications, while Alan J. Sinclair recognized significant contributor field. Key hotspots include complications associated frailty, epidemiology, quality life. Additionally, timeline suggests that nephropathy currently at forefront area. Conclusion comprehensive underscores necessity for improved international collaboration further investigate mechanisms underlying devise more effective prevention treatment strategies. Future should emphasize relationship between well development personalized intervention programs tailored frail

Language: Английский

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Medication use patterns among older patients in temporary stays in Denmark

European Geriatric Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: May 7, 2025

Abstract Purpose Patients in temporary stays are typically older individuals with frailty and multimorbidity. However, limited knowledge exists about their medication use. This study aimed to describe prescription drug use among patients Denmark. Methods We conducted a utilisation on 11,424 public healthcare-operated stay units across 14 Danish municipalities between 2016 2023 (median age 81 years; 54% women). Prescription data were sourced from the National Registry. Results used median of six classes (interquartile range [IQR] 4–10) four months before moving into facility; 68% ≥ 5 classes, 26% 10. The most commonly paracetamol (49%), statins (30%), proton pump inhibitors (29%). monthly rate new increased 23/100 move-in peak 262/100 first month after move-in, driven primarily by laxatives, analgesics, antibiotics. High-risk 70 83% following 49% initiating at least one high-risk drug, opioids (28%), potassium (17%), anticoagulants platelet (15%). General practitioners initiated 60–70% treatments maintained 80–90%. Hospital physician prescriptions around peaking 55% for initiation 25% maintenance move-in. Conclusion Denmark demonstrate high use, including drugs, notable increase treatment initiations time

Language: Английский

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Undernutrition and sarcopenic obesity according to the GLIM criteria phenotype in elderly patients with diabetes

Nippon Ronen Igakkai Zasshi Japanese Journal of Geriatrics, Journal Year: 2024, Volume and Issue: 61(3), P. 322 - 328

Published: July 25, 2024

To evaluate the frequency of malnutrition and sarcopenic obesity in elderly patients with diabetes according to Global Leadership Initiative on Malnutrition (GLIM) phenotypes.

Language: Английский

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