The prognostic value of Clinical Frailty Scale in COVID-19 pneumonia across different pandemic phases: a comparison between the first and the fourth wave

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: March 27, 2025

Introduction The COVID-19 pandemic has placed unprecedented strain on health-care systems. Frailty is being used in clinical decision making for patients with COVID-19, yet the prevalence and effect of frailty people may be influenced by local characteristics each wave. We aimed to establish older who were admitted hospital investigate its association mortality comparing non-vaccinated first wave versus vaccinated fourth Materials methods This was an observational study conducted at one single center Italy. All adults (≥70 years) confirmed (positive molecular testing) included. Data 658 (493 during 165 against wave), collected from records including symptom type, extension lung abnormalities chest computed tomography (CT), laboratory parameters. assessed Clinical Scale (CFS) grouped according their score (≤4: fit or pre-frail; 5–6 = initial signs but some degree independence; >7 severe very frailty). primary outcome in-hospital mortality. Results In comparison wave, unvaccinated had reduced heart disease (35% vs. 56%), renal failure (9% 15%), higher fever time diagnosis (84% 59%), malignancy (16% 6%), (CT) severity visual score, CRP (C-reactive protein) serum levels (median value 105 mg/L 75 mg/L), lower burden frailty. a stepwise multivariable logistic regression model, risk death regardless CFS [Odds Ratio (OR) 2.241, 95% confidence interval (CI) 1.492–3.336, p < 0.001], while significantly associated Conclusion Our suggests that unable stratify death.

Language: Английский

Comment on: “Polypharmacy and Antibody Response to SARS-CoV-2 Vaccination in Residents of Long-Term Care Facilities: the GeroCovid Study”

Drugs & Aging, Journal Year: 2024, Volume and Issue: 41(3), P. 283 - 285

Published: Feb. 28, 2024

Language: Английский

Mental illness and antibody responses after COVID-19 vaccination in a prospective population-based study in Catalonia

Vaccine, Journal Year: 2024, Volume and Issue: 45, P. 126591 - 126591

Published: Dec. 12, 2024

Background Mental illnesses have been overlooked as a potential factor influencing antibody responses to COVID-19 vaccine. Associations between mental disorders and response might vary by specific disorders, depend on the long-term course of illness relate psychotropic treatment.

Language: Английский