Effect of ketone monoester supplementation on elite operators’ mountaineering training DOI Creative Commons
Toshiya Miyatsu, Jeremy S. McAdam,

Kody Coleman

et al.

Frontiers in Physiology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 3, 2024

Introduction Special Operations Forces (SOF) often conduct operations in physiologically stressful environments such as severe heat, cold, or hypoxia, which can induce decreases a variety of cognitive abilities. Given the promising empirical demonstration efficacy exogenous ketone monoester (KME) supplementation attenuating performance decrease during hypoxia at rest laboratory setting, we conducted real-world, field experiment examining KME’s high-altitude mountaineering, an austere environment US SOF have increasing numbers over past two decades. Methods Specifically, 34 students and cadre Army 10th Group Advanced Mountaineering School (SOAMS) participated randomized, double-blind, placebo (PLA)–controlled crossover trial (KME vs. PLA) 2 days tactical mountain training. The participants ascended from 7,500 ft altitude (basecamp) to 12,460 on 1 day 13,627 other (in randomized order), while performing various training activities inducing high physical loads 8–12 h, consumed six doses KME PLA 2–3 h apart throughout each day. Results Discussion While increased blood levels decreased glucose levels, there were no clear indications that elevated level enhanced performance. also produced greater incidence heartburn, nausea, vomiting. In these elite operators, mountaineering had limited impact performance, did not demonstrate any benefit.

Language: Английский

Nutritional Considerations During Major Weight Loss Therapy: Focus on Optimal Protein and a Low-Carbohydrate Dietary Pattern DOI Creative Commons
Jeff S. Volek, Madison L. Kackley, Alex Buga

et al.

Current Nutrition Reports, Journal Year: 2024, Volume and Issue: 13(3), P. 422 - 443

Published: May 30, 2024

Considering the high prevalence of obesity and related metabolic impairments in population, unique role nutrition has weight loss, reversing disorders, maintaining health cannot be overstated. Normal well-being are compatible with varying dietary patterns, but for last half century there been a strong emphasis on low-fat, low-saturated fat, high-carbohydrate based approaches. Whereas low-fat patterns can effective subset individuals, we now have population where vast majority adults excess adiposity some degree impairment. We also entering new era greater access to bariatric surgery approval anti-obesity medications (glucagon-like peptide-1 analogues) that produce substantial loss many people, concerns about disproportionate lean mass nutritional deficiencies.

Language: Английский

Citations

6
Ketone Monoester Plus Carbohydrate Supplementation Does Not Alter Exogenous and Plasma Glucose Oxidation or Metabolic Clearance Rate During Exercise in Men Compared with Carbohydrate Alone DOI Creative Commons
Emily E. Howard,

Jillian T. Allen,

Julie L. Coleman

et al.

Journal of Nutrition, Journal Year: 2023, Volume and Issue: 153(6), P. 1696 - 1709

Published: March 8, 2023

Language: Английский

Citations

11
Intravenous and oral whole body ketone dosimetry, biodistribution, metabolite correction and kinetics studied by (R)-[1-11C]β-hydroxybutyrate ([11C]OHB) PET in healthy humans DOI Creative Commons
Thien Vinh Luong, Erik H. Nielsen,

Lise Falborg

et al.

EJNMMI Radiopharmacy and Chemistry, Journal Year: 2023, Volume and Issue: 8(1)

Published: June 14, 2023

Ketones are increasingly recognized as an important and possibly oxygen sparing source of energy in vital organs such the heart, brain kidneys. Drug treatments, dietary regimens oral ketone drinks designed to deliver ketones for organ tissue production have therefore gained popularity. However, whether ingested taken up by various extra-cerebral tissues what extent is still largely unexplored. It was aim this study use positron emission tomography (PET) explore whole body dosimetry, biodistribution kinetics tracer (R)-[1-11C]β-hydroxybutyrate ([11C]OHB). Six healthy subjects (3 women 3 men) underwent dynamic PET studies after both intravenous (90 min) (120 administration [11C]OHB. Dosimetry estimates [11C]OHB calculated using OLINDA/EXM software, assessed visually were obtained arterial input function time-activity curves.Radiation dosimetry yielded effective doses 3.28 [Formula: see text]Sv/MBq (intravenous administration) 12.51 (oral administration). Intravenous resulted avid radiotracer uptake liver, kidneys, whereas lesser observed salivary glands, pancreas, skeletal muscle red marrow. Only minimal noted brain. Oral ingestion rapid appearance blood liver In general, best described a reversible 2-tissue compartmental model.The shows promising potential providing imaging data on physiologically relevant tissues. As result, it may serve safe non-invasive tool exploring metabolism patients individuals. Trial registration Clinical trials, NCT0523812, Registered February 10th 2022, https://clinicaltrials.gov/ct2/show/NCT05232812?cond=NCT05232812&draw=2&rank=1 .

Language: Английский

Citations

10
The role of myocardial energy metabolism perturbations in diabetic cardiomyopathy: from the perspective of novel protein post-translational modifications DOI Creative Commons
Dongze Li, Li Zhang, Qiming Gong

et al.

Clinical Epigenetics, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 26, 2025

Diabetic cardiomyopathy (DbCM), a significant chronic complication of diabetes, manifests as myocardial hypertrophy, fibrosis, and other pathological alterations that substantially impact cardiac function elevate the risk cardiovascular diseases patient mortality. Myocardial energy metabolism disturbances in DbCM, encompassing glucose, fatty acid, ketone body lactate metabolism, are crucial factors contribute to progression DbCM. In recent years, novel protein post-translational modifications (PTMs) such lactylation, β-hydroxybutyrylation, succinylation have been demonstrated be intimately associated with process, conjunction acetylation, they participate regulation activity gene expression cardiomyocytes. This review examines epigenetic pathogenesis primarily focusing on perturbations PTMs them. It provides detailed analysis mechanisms these DbCM enhance understanding pathophysiology establish theoretical foundation for development new treatment strategies

Language: Английский

Citations

0
A ketogenic‐promoting beverage acutely elevates cardiac function and myocardial blood flow compared to placebo in adults: A cardiac MRI investigation DOI Creative Commons
Christopher D. Crabtree, Yue Pan, Preethi Chandrasekaran

et al.

Physiological Reports, Journal Year: 2025, Volume and Issue: 13(6)

Published: March 1, 2025

Abstract Increasing evidence suggests cardiac function improves in healthy and failing hearts alongside circulating ketones (1–4 mM). This study characterized blood flow responses to a ketogenic beverage compared volume/calorie matched placebo with repeated imaging over 120 min. was two‐group, placebo‐controlled, acute study. Adults without abnormalities underwent baseline MRI including quantitative myocardial perfusion measure (MBF). Subjects consumed 50 g of ketogenic‐promoting [bis‐hexanoyl R‐1‐3‐butanediol (BH‐BD)] (BH‐BD; n = 11) or calorically/volume‐matched lipid‐based (PL; 10) every 15–30 Following min, subjects final scan MBF measurement. R‐BHB glucose were measured at timepoint. min following BH‐BD consumption, reached 2.1 mM. Cardiac output (CO) elevated PL ( p < 0.05) increased +31% after ingestion 0.001). CO elevation due stroke volume (+11%; 0.02) heart rate (+22%; 29% from did not induce differences parameters. achieves exogenous ketosis is associated providing supporting their use as therapeutic clinical agent.

Language: Английский

Citations

0
Metabolic Adaptations and Therapies in Cardiac Hypoxia: Mechanisms and Clinical Implications/ Potential Strategies DOI Creative Commons
Huili Li, Fei Xiao,

Chenghui Zhou

et al.

JACC Basic to Translational Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Cardiac hypoxia triggers a cascade of responses and functional changes in myocardial non-myocardial cells, profoundly affecting cellular metabolism, oxygen-sensing mechanisms, immune responses. Myocardial being the primary cell type cardiac tissue, undergo significant alterations energy including glycolysis, fatty acid ketone body utilization, branched-chain amino to maintain function under hypoxic conditions. Non-myocardial such as fibroblasts, endothelial although fewer number, play crucial roles regulating homeostasis, maintaining structural integrity, responding injury. This review discusses metabolic reprogramming particularly macrophages, during ischemia-reperfusion injury explores various therapeutic strategies that modulate these pathways protect heart hypoxia. Understanding interactions provides valuable insights potential targets for disease treatment.

Language: Английский

Citations

0
SPORCU PERFORMANSINI ARTIRAN GÜNCEL BESİN TAKVİYELERİ DOI Open Access
Hakan Bor

Ankara Üniversitesi Beden Eğitimi ve Spor Yüksekokulu SPORMETRE Beden Eğitimi ve Spor Bilimleri Dergisi, Journal Year: 2025, Volume and Issue: 23(1), P. 189 - 233

Published: March 30, 2025

Sporcu performansını artırmak amacıyla kullanılan besin takviyeleri teknolojinin ilerlemesiyle birlikte bu takviyelerin çeşitliliğinin ve erişilebilirliğinin artması nedeniyle geçmişe kıyasla daha fazla ön plana çıkmıştır. Bu bağlamda çalışmada takviyelerinin sporcu hangi yönlerden etkilediği sağlıklı kullanım dozajlarının nasıl olması gerektiği güncel literatür yardımıyla açıklanmaya çalışılmıştır. Araştırmada öncelikle hakkında genel bir bilgi verilerek tanıtılmış sonrasında her takviyesinin özelliklerine uygun olarak performansı üzerindeki olası etkilerinden bahsedilmiştir. Ayrıca dozajları konusunda son dokuz yıldaki literatürde var olan öneriler çalışma içinde sunulmuştur. Bir beslenme uzmanı yardımı alınarak doğru şekilde tüketilen farklı etki mekanizmaları yoluyla olumlu etkilemektedir. Sporcuların kısmı için diyetlerini yeniden planlayarak takviyelerine ihtiyaç karşılanabilirken, diğer performans gösterdikleri spor dalı diyetle alınan miktar yeterli olmayıp uzman kontrolünde takviyelerini diyetlerine ek almaları gerekmektedir. nedenle sporcuların yan dolayı sağlık açısından zarar görmemeleri en üst düzeyde fayda elde edebilmeleri sporcunun fiziksel durumuna, dalına diyetine olacak takviyesi alımının bilimsel çalışmalardaki doğrultusunda bireye özgü planlanması büyük önem taşımaktadır.

Citations

0
A randomized, open-label, parallel pilot study investigating metabolic product kinetics of the novel ketone ester, bis-hexanoyl (R)-1,3-butanediol, over one week of ingestion in healthy adults DOI Creative Commons
Eunice Mah, Traci M. Blonquist,

Valerie N Kaden

et al.

Frontiers in Physiology, Journal Year: 2023, Volume and Issue: 14

Published: June 22, 2023

Introduction: Bis-hexanoyl (R)-1,3-butanediol (BH-BD) is a novel ketone ester that, when consumed, hydrolyzed into hexanoic acid (HEX) and (BDO) which are subsequently metabolized beta-hydroxybutyrate (BHB). Methods: We undertook randomized, parallel, open-label study in healthy adults ( n = 33) to elucidate blood BHB, HEX BDO concentrations for 8 h following consumption of three different serving sizes (SS) BH-BD (12.5, 25 50 g/day) before (Day 0) after 7 days daily 7). Results: Maximal concentration area under the curve all metabolites increased proportionally SS were greatest BHB followed by then on both Day 0 7. Metabolite half-life tended decrease with increasing HEX. Time peak days. In vitro incubation human plasma demonstrated undergoes rapid spontaneous hydrolysis. Conclusion: These results demonstrate that orally ingested products appear undergo conversion dependent manner, metabolism neither becomes saturated at up g nor displays consistent adaptation consumption.

Language: Английский

Citations

8
Acute ketone supplementation in the absence of muscle glycogen utilization: Insights from McArdle disease DOI
Pedro L. Valenzuela, Alfredo Santalla, Lidia B. Alejo

et al.

Clinical Nutrition, Journal Year: 2024, Volume and Issue: 43(3), P. 692 - 700

Published: Jan. 26, 2024

Language: Английский

Citations

3
Ketone monoester attenuates declines in cognitive performance and oxygen saturation during acute severe hypoxic exposure under resting conditions DOI Creative Commons

Tyler S. McClure,

Jeffrey J. Phillips,

Andrew P. Koutnik

et al.

Experimental Physiology, Journal Year: 2024, Volume and Issue: 109(10), P. 1672 - 1682

Published: Aug. 27, 2024

Abstract Exogenous ketone supplements are a potential augmentation strategy for cognitive resilience during acute hypoxic exposure due to their capacity attenuate the decline in oxygen (O 2 ) availability, and by providing an alternative substrate cerebral metabolism. Utilizing single‐blind randomized crossover design, 16 male military personnel (age, 25.3 ± 2.4 year, body mass, 86.2 9.3 kg) performed tests of performance at rest three environments: room air (baseline), normoxia (20 min; 0 m; 20.9% O hypoxia 6096 m, 9.7% using reduced breathing device (ROBD). ( R )‐3‐Hydroxybutyl )‐3‐hydroxybutyrate (R‐BD R‐βHB) monoester (KME; 650 mg/kg, split dose given 30 min prior each exposure) or taste‐matched placebo (PLA) was ingested exposure. Blood R‐βHB glucose concentrations, saturation () were collected throughout. KME ingestion increased blood concentration, which rapid sustained (>4 mM post; P < 0.001) accompanied lower concentration (∼20 mg/dL; 0.01) compared PLA. Declines exposure, assessed as efficiency Defense Automated Neurobehavioral Assessment (DANA) code substitution task, attenuated with leading 6.8 (95% CL: 1.0, 12.6) more correct responses per minute PLA = 0.018). The (6.40% ; 95% 0.04, 12.75; 0.049) (KME, 76.8 6.4% PLA, 70.4 7.4% ). Acute severe coincided attenuation declines saturation.

Language: Английский

Citations

3