Production, Formulation, and Application of Postbiotics in the Treatment of Skin Conditions

Fermentation, Journal Year: 2023, Volume and Issue: 9(3), P. 264 - 264

Published: March 7, 2023

The skin microbiome is composed of a complex association bacteria, fungi, and viruses. maintenance commensal microbes essential for preventing the overgrowth pathogenic microorganisms or already present opportunistic pathogens. Thus, development bioactive compounds capable modulating has become an important topic both researchers cosmetic industry. Increasingly, scientific evidence highlights that metabolites derived from probiotics have great potential to prevent diseases affecting skin. These recently been called postbiotics are defined as “preparation inanimate and/or their components confers health benefit on host”. Postbiotics obtained fermentations performed almost exclusively by lactic acid bacteria yeast. Short-chain fatty acids, bacteriocins, organic acids some examples postbiotics. exhibit antimicrobial, immunomodulatory, antioxidant, anti-inflammatory activities. In addition, postbiotic production possesses technological advantages, including high stability increased safety, compared viable probiotics. this article, model large-scale uses in formulations reviewed. results vivo tests treatment alopecia, acne, atopic dermatitis, wound healing discussed. Finally, advances shown based survey main patents filed area

Language: Английский

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Exerkines and cardiometabolic benefits of exercise: from bench to clinic

EMBO Molecular Medicine, Journal Year: 2024, Volume and Issue: 16(3), P. 432 - 444

Published: Feb. 6, 2024

Abstract Regular exercise has both immediate and long-lasting benefits on cardiometabolic health, been recommended as a cornerstone of treatment in the management diabetes cardiovascular conditions. Exerkines, which are defined humoral factors responsive to acute or chronic exercise, have emerged important players conferring some multiple exercise. Over past decades, hundreds exerkines released from skeletal muscle, heart, liver, adipose tissue, brain, gut identified, several (such FGF21, IL-6, adiponectin) exploited therapeutically mimetics for various metabolic diseases. Recent advances metagenomics led identification microbiota, so-called “hidden” organ, an additional class determining efficacy prevention, cardiac protection, performance. Furthermore, multiomics-based studies shown feasibility using baseline exerkine signatures predict individual responses with respect cardiorespiratory health. This review aims explore molecular pathways whereby networks mediate adaptations by fine-tuning inter-organ crosstalk, discuss roadmaps translating exerkine-based discovery into therapeutic application personalized medicine disease.

Language: Английский

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Epithelial barrier theory in the context of nutrition and environmental exposure in athletes

Allergy, Journal Year: 2024, Volume and Issue: 79(11), P. 2912 - 2923

Published: July 16, 2024

Exposure to toxic substances, introduced into our daily lives during industrialization and modernization, can disrupt the epithelial barriers in skin, respiratory, gastrointestinal systems, leading microbial dysbiosis inflammation. Athletes physically active individuals are at increased risk of exposure agents that damage microbiome, their extreme physical exercise exerts stress on many organs, resulting tissue Epithelial barrier-damaging substances include surfactants enzymes cleaning products, laundry dishwasher detergents, chlorine swimming pools, microplastics, air pollutants such as ozone, particulate matter, diesel exhaust. Athletes' high-calorie diet often relies processed foods may contain food emulsifiers other additives cause barrier dysfunction dysbiosis. The type material used sport equipment clothing extensive increase inflammatory effects. Excessive travel-related stress, sleep disturbances different microbe represent additional factors. Here, we review detrimental impact microbiome; bring a new perspective factors affecting health performance athletes individuals.

Language: Английский

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Microbiome and physical activity

Advances in genetics, Journal Year: 2024, Volume and Issue: unknown, P. 409 - 450

Published: Jan. 1, 2024

Language: Английский

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Physical Exercise and the Gut Microbiome: A Bidirectional Relationship Influencing Health and Performance

Nutrients, Journal Year: 2024, Volume and Issue: 16(21), P. 3663 - 3663

Published: Oct. 28, 2024

Background/Objectives: The human gut microbiome is a complex ecosystem of microorganisms that can influence our health and exercise habits. On the other hand, physical also impact microbiome, affecting health. Our narrative review examines bidirectional relationship between activity as well potential for targeted probiotic regimens to enhance sports performance. Methods: We conducted comprehensive literature select articles published up till January 2024 on topics exercise, sports, probiotics, microbiota from major scientific databases, incorporating over 100 studies. Results: found varies with type intensity exercise. Moderate promotes healthy immune system, while high-intensity long duration cause leaky consequent systemic inflammation, which may disrupt microbial balance. Combining aerobic resistance training significantly affects bacterial diversity, linked lower prevalence chronic metabolic disorders. Furthermore, enhances increases SCFA production, improves nutrient utilization, modulates neural hormonal pathways, improving barrier integrity. findings showed supplementation associated decreased enhanced performance, fewer gastrointestinal disturbances, suggesting mutually influential. Conclusions: exemplified by how promote beneficial bacteria potentially ability through various mechanisms. These underscore importance adding tailored consider individual profiles into programs.

Language: Английский

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What if gastrointestinal complications in endurance athletes were gut injuries in response to a high consumption of ultra-processed foods? Please take care of your bugs if you want to improve endurance performance: a narrative review

European Journal of Applied Physiology, Journal Year: 2023, Volume and Issue: 124(2), P. 383 - 402

Published: Oct. 15, 2023

Language: Английский

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Humanistic Health Management and Cancer: Associations of Psychology, Nutrition, and Exercise with Cancer Progression and Pathogenesis

Advanced Science, Journal Year: 2024, Volume and Issue: 11(22)

Published: March 25, 2024

Abstract The incidence rate of cancer is increasing year by due to the aging population, unhealthy living, and eating habits. At present, surgery medication are still main treatments for cancer, without paying attention impact individual differences in health management on cancer. However, evidence suggests that psychological status, dietary habits, exercise frequency closely related risk prognosis reminder humanity medical concept unified treatment plan insufficient treatment, a personalized may become breakthrough point. On this basis, “Humanistic Health Management” (HHM) proposed. This healthcare focuses self‐health management, providing an accurate comprehensive evaluation lifestyle psychology, developing targeted prevention plans. review will provide detailed explanation relationship between dietary, regulatory mechanisms Intended emphasize importance HHM better prognostic efficacy, new ideas generation treatment.

Language: Английский

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A Lactobacillus consortium provides insights into the sleep-exercise-microbiome nexus in proof of concept studies of elite athletes and in the general population

Microbiome, Journal Year: 2025, Volume and Issue: 13(1)

Published: Jan. 2, 2025

Abstract Background The complex relationship among sleep, exercise, and the gut microbiome presents a unique opportunity to improve health wellness. Here, we conducted first large-scale investigation into influence of novel elite athlete-derived probiotic, consisting multi-strain Lactobacillus consortium, on sleep quality, exercise recovery, composition in both athletes ( n = 11) general population 257). Results Our two-phase study design, which included an open-label followed by controlled longitudinal professional soccer team, allowed us identify key interactions between probiotics, microbiome, host. In placebo-controlled study, observed significant improvements self-reported quality 69%, energy levels 31%, bowel movements 37% after probiotic intervention relative placebo. These were associated with decrease D-ROMS (a marker oxidative stress) significantly higher free-testosterone/cortisol ratio. Multi-omics analyses revealed specific changes function, potentially providing mechanistic insights these effects. Conclusion This provides how modulates athletes, introduces potential mechanisms through this could be influencing overall health. results emphasize untapped tailored interventions derived from extremely fit healthy individuals improving several aspects performance directly humans.

Language: Английский

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Gut Microbiota Alteration with Moderate-to-Vigorous-Intensity Exercise in Middle School Female Football Athletes

Biology, Journal Year: 2025, Volume and Issue: 14(2), P. 211 - 211

Published: Feb. 17, 2025

The gut microbiota significantly influences health and metabolic processes. This study aimed to investigate the impact of exercise intensity on middle school female football athletes. In this four-week controlled comparative study, twenty-nine participants were divided into three groups: non-exercise group (NEG), moderate-intensity (MIEG), vigorous-intensity (VIEG). They followed their respective regimens for four weeks. Fecal samples collected 16S rRNA gene sequencing evaluate composition. MIEG exhibited greater microbial diversity compared NEG, while VIEG showed lower than MIEG. Various profiles identified, with having higher levels beneficial bacteria such as Bacteroides. Moderate-intensity promotes a healthier vigorous in young These findings underscore potential moderate enhance may inform training strategies adolescent

Language: Английский

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Nutrition as an effective preventative medicine

UK-Vet Equine, Journal Year: 2025, Volume and Issue: 9(2), P. 58 - 65

Published: March 2, 2025

Nutrition plays a pivotal role in maintaining optimal health, influencing physical wellbeing, performance and behaviour. Horse owners frequently rely on veterinarians for expert advice nutrition, but many report lack of confidence their nutritional expertise. Poor dietary practices can lead to significant health issues. This review examines the nutrition as an effective preventative medicine, addressing challenges face equine guidance growing body research highlighting importance good its link disease. Additionally, explores advancements understanding gut microbiome, including impact various interventions such prebiotics, probiotics postbiotics. With rising interest these offer promising strategies enhance disease resistance horses. Finally, discusses practical approaches optimising potential supplements, while emphasising evidence-based veterinary nutrition.

Language: Английский

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